Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tuula, Koskelainen"'
Autor:
Norbert Nagy, Kaisa Syrjänen, Piet Finckenberg, Gerd Wohlfahrt, Jouko Levijoki, Tuula Koskelainen, A. Koivisto, András Varró, Paul E. Miller, László Virág, Najah Abi-Gerges, Leena Otsomaa, Eero Mervaala, Andrea Ghetti, Hugh Chapman, Saara‐Elisa Peltokorpi, Aira Heikkilä, Norbert Jost, Guy Page, Julius Gy. Papp, Zsófia Kohajda
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE: The lack of selective sodium-calcium exchanger (NCX) inhibitors has hampered the exploration of physiological and pathophysiological roles of cardiac NCX 1.1. We aimed to discover more potent and selective drug like NCX 1.1 in
Autor:
Zsófia Kohajda, Nikolett Farkas-Morvay, Norbert Jost, Norbert Nagy, Amir Geramipour, András Horváth, Richárd S Varga, Tibor Hornyik, Claudia Corici, Károly Acsai, Balázs Horváth, János Prorok, Balázs Ördög, Szilvia Déri, Dániel Tóth, Jouko Levijoki, Piero Pollesello, Tuula Koskelainen, Leena Otsomaa, András Tóth, István Baczkó, István Leprán, Péter P Nánási, Julius Gy Papp, András Varró, László Virág
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166041 (2016)
In this study the effects of a new, highly selective sodium-calcium exchanger (NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca2+ transients, cell shortening and in experimental arrhythmias. The level of selectivity of the novel
Externí odkaz:
https://doaj.org/article/61d59a8ac797493b98a5af678d4d4f1a
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 77:129005
Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candida
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 69:128783
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
Autor:
Gudrun Antoons, Norbert Nagy, Károly Acsai, Piero Pollesello, Zsófia Kohajda, Jouko Levijoki, Kinga Oravecz, Zoltán Márton, Norbert Jost, Leila Mirzaei, Tuula Koskelainen, Andrea Gruber, Péter P. Nánási, András Varró, András Tóth, Leena Otsomaa, Julius Gy. Papp, Anita Kormos
Publikováno v:
European Journal of Pharmacology, 818, 278-286. Elsevier Science
Na+/Ca2+ exchanger (NCX) is the main Ca2+ transporter in cardiac myocytes. Its inhibition could be expected to exert positive inotropic action by accumulation of cytosolic Ca2+ ([Ca2+](i)). However, we have observed only a marginal positive inotropic
Autor:
László Virág, Peter Biliczki, Aniko Horvath, Jouko Levijoki, András Tóth, Leena Otsomaa, Zsófia Kohajda, Károly Acsai, Norbert Jost, Claudia Corici, Norbert Nagy, Tuula Koskelainen, András Varró, J. Gy. Papp, Piero Pollesello
Publikováno v:
British Journal of Pharmacology. 170:768-778
Background and Purpose At present there are no small molecule inhibitors that show strong selectivity for the Na+/Ca2+ exchanger (NCX). Hence, we studied the electrophysiological effects of acute administration of ORM-10103, a new NCX inhibitor, on t
Autor:
Péter P. Nánási, Tuula Koskelainen, András Varró, István Leprán, Nikolett Farkas-Morvay, Piero Pollesello, Norbert Nagy, András Tóth, Jouko Levijoki, Zsófia Kohajda, Leena Otsomaa, András Horváth, László Virág, Károly Acsai, Dániel Tóth, Norbert Jost, Richárd S. Varga, Julius Gy. Papp, Balázs Ördög, Claudia Corici, János Prorok, Tibor Hornyik, István Baczkó, Szilvia Déri, Amir Geramipour, Balázs Horváth
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 11, p e0166041 (2016)
PLoS ONE, Vol 11, Iss 11, p e0166041 (2016)
Background In this study the effects of a new, highly selective sodium-calcium exchanger (NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca2+ transients, cell shortening and in experimental arrhythmias. The level of selectivity o