Výsledky vyhledávání

Exploring paclitaxel-loaded adenosine-conjugated PEGylated PLGA nanoparticles for targeting triple-negative breast cancer

Autor: Dasharath Chaudhari, Kaushik Kuche, Vivek Yadav, Rohan Ghadi, Tushar Date, Nallamothu Bhargavi, Sanyog Jain

Publikováno v: Drug delivery and translational research.

In present investigation, we developed paclitaxel (PTX)-loaded adenosine (ADN)-conjugated PLGA nanoparticles for combating triple-negative breast cancer (TNBC), where ADN acts as a substrate for adenosine receptors (AR) that are overexpressed in TNBC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9002ef2ca6a05519c846f9ee378f6e
https://pubmed.ncbi.nlm.nih.gov/36528709

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Self-nanoemulsifying formulation for oral delivery of sildenafil: effect on physicochemical attributes and in vivo pharmacokinetics

Autor: Sanyog Jain, Narinder Kumar, Reena Sharma, Rohan Ghadi, Tushar Date, Nallamothu Bhargavi, Dasharath Chaudhari, Sameer S. Katiyar

Publikováno v: Drug delivery and translational research.

Sildenafil (SLD) is employed for the management of erectile dysfunction and pulmonary arterial hypertension. It exhibits meagre water solubility and is available in the form of citrate salt hydrate to improve the solubility. However, it still exhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e076d2f81e2ecedda57f67ae849431
https://pubmed.ncbi.nlm.nih.gov/36223029

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Unfolding the Potency of Adenosine in Targeting Triple Negative Breast Cancer via Paclitaxel-Incorporated pH-Responsive Stealth Liposomes

Autor: Dasharath Chaudhari, Oly Katari, Rohan Ghadi, Kaushik Kuche, Tushar Date, Nallamothu Bhargavi, Sanyog Jain

Publikováno v: ACS biomaterials scienceengineering. 8(8)

Triple-negative breast cancer (TNBC) belongs to the category of the most destructive forms of breast cancer. Being a highly potent chemotherapeutic agent, paclitaxel (PTX) is extensively utilized in the management of various cancers. Commercially ava

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097affca506b95bfe4a4c57565cc2938
https://pubmed.ncbi.nlm.nih.gov/35896042

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Hitting Multiple Cellular Targets in Triple-Negative Breast Cancer Using Dual-Action Cisplatin(IV) Prodrugs for Safer Synergistic Chemotherapy

Autor: Tushar Date, Kaushik Kuche, Dasharath Chaudhari, Rohan Ghadi, Deepak Kumar Sahel, Deepak Chitkara, Sanyog Jain

Publikováno v: ACS biomaterials scienceengineering. 8(6)

Triple-negative breast cancer (TNBC) cells show improved sensitivity for cisplatin therapy due to their defective DNA damage repair system. However, the clinical utilization of cisplatin is limited by dose-dependent systemic toxicities and chemoresis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0fa99ec6f3cfd4defac9f0a1f1e1c3
https://pubmed.ncbi.nlm.nih.gov/35522530

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Understanding the Role of Axial Ligands in Modulating the Biopharmaceutical Outcomes of Cisplatin(IV) Derivatives

Autor: Tushar Date, Kaushik Kuche, Rohan Ghadi, Pradeep Kumar, Sanyog Jain

Publikováno v: Molecular pharmaceutics. 19(5)

Cisplatin is a platinum (Pt)-based anticancer drug with broad-scale clinical utility. However, due to its hydrophilic nature and high kinetic reactivity, it offers numerous drug delivery challenges. Limitations such as severe systemic toxicities, che

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb0cf4f2076e654b751818ac7d99aa3
https://pubmed.ncbi.nlm.nih.gov/35437994

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Improved Oral Bioavailability and Gastrointestinal Stability of Amphotericin B through Fatty Acid Conjugation Approach

Autor: Kaushik Thanki, Tushar Date, Sanyog Jain

Publikováno v: Molecular Pharmaceutics. 16:4519-4529

Amphotericin B (AmB) is one of the most effective drugs used in the treatment of leishmaniasis and systemic fungal infections. Considering the global burden of leishmaniasis, ∼90% of disease cases occur in developing countries, suggestive of the ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe51e9dd4dcd3c744de73c735a5084d
https://doi.org/10.1021/acs.molpharmaceut.9b00662

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Mechanistic insights into high permeation vesicle-mediated synergistic enhancement of transdermal drug permeation

Autor: Tushar Date, Sameer S. Katiyar, Sanyog Jain, Mahesh Katariya, Rajan Swami, Varun Kushwah, Pragati Khare

Publikováno v: Nanomedicine. 14:2227-2241

Aim: To design a nanocarrier platform for enhanced transdermal drug permeation. Materials & methods: Gel-based high permeation vesicles (HPVs) were developed and their performance in terms of transdermal flux improvement, in vitro release and skin ir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170fd5c8664bde1f8c75e39f35d957cf
https://doi.org/10.2217/nnm-2018-0519

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Succinylated β-Lactoglobuline-Functionalized Multiwalled Carbon Nanotubes with Improved Colloidal Stability and Biocompatibility

Autor: Tushar Date, Rahul R. Mahajan, Sanyog Jain, Tushar Kumeria, Naisarg Pujara, Varun Kushwah, Shesherao M. Dongave, Amirali Popat

Publikováno v: ACS Biomaterials Science & Engineering. 5:3361-3372

PEGylation (i.e., attachment of polyethylene-glycol) of carbon nanotubes (CNTs) is one of the most widely used strategies to improve its biocompatibility and aqueous dispersion stability, which are critical for their successful clinical application.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edf2b73ee67182550d1412910c4ff2d
https://doi.org/10.1021/acsbiomaterials.9b00268

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