Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tushar B. Deb"'
Autor:
Milton L. Brown, Rebecca B. Riggins, Yali Kong, Venkata Mahidhar Yenugonda, Yonghong Yang, Tushar B. Deb
Publikováno v:
Cancer Biology & Therapy. 13:925-934
Resveratrol (RSV), a natural compound present in the skin and seeds of red grapes, is considered a phytoestrogen and has structural similarity to the synthetic estrogen diethylstilbestrol. RSV inhibits tumor cell growth in estrogen receptor-positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56a7411c5fdab2a9c10c858c2a1ad74
https://doi.org/10.4161/cbt.20845
https://doi.org/10.4161/cbt.20845
Autor:
Annie H. Zuo, Amrita K. Cheema, Robert J. Barndt, Surojeet Sengupta, Youhong Wang, Michael D. Johnson, Christine M. Coticchia, Tushar B. Deb
Publikováno v:
American Journal of Physiology-Cell Physiology. 300:C1139-C1154
We have recently described a novel role for pregnancy-upregulated nonubiquitous calmodulin kinase (Pnck) in the induction of ligand-independent epidermal growth factor receptor (EGFR) degradation (Deb TB, Coticchia CM, Barndt R, Zuo H, Dickson RB, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdb032f36f84d522ffd7f35ad5ed88b
https://doi.org/10.1152/ajpcell.00167.2010
https://doi.org/10.1152/ajpcell.00167.2010
Autor:
Annie H. Zuo, Tushar B. Deb, Robert J. Barndt, Michael D. Johnson, Radmila Jankovic, Surojeet Sengupta
Publikováno v:
Breast cancer research and treatment. 150(2)
The gene for Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (Pnck), a novel calmodulin kinase, is expressed in roughly one-third of human breast tumors, but not in adjoining normal tissues. Pnck alters EGFR stability and function, prompting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818ed2b5eacd82559f7b6ac0c6bc7860
https://pubmed.ncbi.nlm.nih.gov/25773930
https://pubmed.ncbi.nlm.nih.gov/25773930
Publikováno v:
Journal of Biological Chemistry. 279:38143-38150
The epidermal growth factor receptor (EGFR) kinase catalyzes phosphorylation of tyrosines in its C terminus and in other cellular targets upon epidermal growth factor (EGF) stimulation. Here, by using peptides derived from EGFR autophosphorylation si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::425988610868c6af0596806806bebfef
https://doi.org/10.1074/jbc.m405760200
https://doi.org/10.1074/jbc.m405760200
PTEN-mediated ERK1/2 inhibition and paradoxical cellular proliferation following Pnck overexpression
Autor:
Christine M. Coticchia, Robert J. Barndt, Annie H. Zuo, Surojeet Sengupta, Michael D. Johnson, Tushar B. Deb
Publikováno v:
Cell cycle (Georgetown, Tex.). 13(6)
Pregnancy upregulated non-ubiquitous calmodulin kinase (Pnck), a novel calmodulin kinase, is significantly overexpressed in breast and renal cancers. We present evidence that at high cell density, overexpression of Pnck in HEK 293 cells inhibits seru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe328ff6a52a42c8e6a4d373998a233
https://pubmed.ncbi.nlm.nih.gov/24552815
https://pubmed.ncbi.nlm.nih.gov/24552815
Autor:
Tushar B. Deb, Mikell Paige, Sivanesan Dakshanamurthy, Venkata Mahidhar Yenugonda, Yonghong Yang, Milton L. Brown, Scott Grindrod
Publikováno v:
Bioorganicmedicinal chemistry. 19(8)
Inhibitors of cyclin-dependent kinases (CDKs) are an emerging class of drugs for the treatment of cancers. CDK inhibitors are currently under evaluation in clinical trials as single agents and as sensitizers in combination with radiation therapy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236a3c5d501762cbbaf09ce35409c355
https://pubmed.ncbi.nlm.nih.gov/21440449
https://pubmed.ncbi.nlm.nih.gov/21440449
Publisher Summary This chapter examines the signaling pathways in the normal and neoplastic breast. The epidermal growth factor (EGF) family members that bind to EGFR are EGF, transforming growth factor α (TGFα), amphiregulin (AR, a heparin-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::228f7ece08797c7132428fce4b50f0ec
https://doi.org/10.1016/b978-0-12-374145-5.00317-x
https://doi.org/10.1016/b978-0-12-374145-5.00317-x
Autor:
Tushar B. Deb, Robert J. Barndt, Michael D. Johnson, Robert B. Dickson, Christine M. Coticchia, Hong Zuo
We describe here an important function of the novel calmodulin kinase I isoform, pregnancy-upregulated nonubiquitous calmodulin kinase (Pnck). Pnck (also known as CaM kinase Iβ2) was previously shown to be differentially overexpressed in a subset of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20d7bef6dc427bd81a3f2c3ab281886
https://europepmc.org/articles/PMC2518423/
https://europepmc.org/articles/PMC2518423/
Autor:
Chetana M. Revankar, Tushar B. Deb, Robert B. Dickson, Michael D. Johnson, Christine M. Coticchia
Publikováno v:
Breast cancer research and treatment. 115(3)
Growth factor-induced activation of Akt occurs in the majority of human breast cancer cell lines resulting in a variety of cellular outcomes, including suppression of apoptosis and enhanced survival. We demonstrate that epidermal growth factor (EGF)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c8ef4d11ef196443ed5f2d55c76715
https://pubmed.ncbi.nlm.nih.gov/18587642
https://pubmed.ncbi.nlm.nih.gov/18587642
Autor:
Robert B. Dickson, Tushar B. Deb
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780387740379
Acquisition of resistance of breast cancer to chemotherapy is commonly associated with progression of the disease to increased metastatic spread. Although early studies on this problem examined the possible roles of chemotherapy drug metabolism and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bef14fdd30b5efe624daff9a89afb2f8
https://doi.org/10.1007/978-0-387-74039-3_8
https://doi.org/10.1007/978-0-387-74039-3_8