Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Tushar, Bhangale"'
Autor:
Stephanie J. Loomis, Nilanjana Sadhu, Elizabeth Fisher, Arie R. Gafson, Yunfeng Huang, Chengran Yang, Emily E. Hughes, Eric Marshall, Ann Herman, Sally John, Heiko Runz, Xiaoming Jia, Tushar Bhangale, Paola G. Bronson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract While the genetics of MS risk susceptibility are well-described, and recent progress has been made on the genetics of disease severity, the genetics of disease progression remain elusive. We therefore investigated the genetic determinants of
Externí odkaz:
https://doaj.org/article/369ef40ed9724f568b60b63614af8013
Autor:
Zia Khan, Min Jung, Megan Crow, Rajat Mohindra, Vidya Maiya, Joshua S. Kaminker, David H. Hackos, G. Scott Chandler, Mark I. McCarthy, Tushar Bhangale
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these tox
Externí odkaz:
https://doaj.org/article/8203af64f2254efdb0211f8800973199
Autor:
Jeffrey D. Wall, J. Fah Sathirapongsasuti, Ravi Gupta, Asif Rasheed, Radha Venkatesan, Saurabh Belsare, Ramesh Menon, Sameer Phalke, Anuradha Mittal, John Fang, Deepak Tanneeru, Manjari Deshmukh, Akshi Bassi, Jacqueline Robinson, Ruchi Chaudhary, Sakthivel Murugan, Zameer ul-Asar, Imran Saleem, Unzila Ishtiaq, Areej Fatima, Saqib Shafi Sheikh, Shahid Hameed, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Anjum Jalal, Shahid Abbas, Philippe Frossard, Christian Fuchsberger, Lukas Forer, Sebastian Schoenherr, Qixin Bei, Tushar Bhangale, Jennifer Tom, Santosh Gopi Krishna Gadde, Priya B V, Naveen Kumar Naik, Minxian Wang, Pui-Yan Kwok, Amit V. Khera, B. R. Lakshmi, Adam S. Butterworth, Rajiv Chowdhury, John Danesh, Emanuele di Angelantonio, Aliya Naheed, Vinay Goyal, Rukmini M. Kandadai, Hrishikesh Kumar, Rupam Borgohain, Adreesh Mukherjee, Pettarusp M. Wadia, Ravi Yadav, Soaham Desai, Niraj Kumar, Atanu Biswas, Pramod Kumar Pal, Uday B. Muthane, Shymal K. Das, Vedam L. Ramprasad, Prashanth L. Kukkle, Somasekar Seshagiri, Sekar Kathiresan, Arkasubhra Ghosh, V. Mohan, Danish Saleheen, Eric W. Stawiski, Andrew S. Peterson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The benefits of large-scale genetic studies for healthcare of the populations studied are well documented, but these genetic studies have traditionally ignored people from some parts of the world, such as South Asia. Here we describe whole g
Externí odkaz:
https://doaj.org/article/c5c553736d824d84a9c6fd8682dcf4dd
Autor:
Luz D. Orozco, Hsu-Hsin Chen, Christian Cox, Kenneth J. Katschke, Jr., Rommel Arceo, Carmina Espiritu, Patrick Caplazi, Sarajane Saturnio Nghiem, Ying-Jiun Chen, Zora Modrusan, Amy Dressen, Leonard D. Goldstein, Christine Clarke, Tushar Bhangale, Brian Yaspan, Marion Jeanne, Michael J. Townsend, Menno van Lookeren Campagne, Jason A. Hackney
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112298- (2023)
Externí odkaz:
https://doaj.org/article/50149307557045f491296fd14962a70c
Autor:
Diana Chang, Julie Hunkapiller, Tushar Bhangale, Jens Reeder, Kiran Mukhyala, Jennifer Tom, Amy Cowgill, Jan Vogel, William F. Forrest, Zia Khan, Amy Stockwell, Mark I. McCarthy, Tracy L. Staton, Julie Olsson, Cecile T. J. Holweg, Dorothy S. Cheung, Hubert Chen, Matthew J. Brauer, Robert R. Graham, Timothy Behrens, Mark S. Wilson, Joseph R. Arron, David F. Choy, Brian L. Yaspan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Genome-wide association studies (GWAS) have identified many common variant loci associated with asthma susceptibility, but few studies investigate the genetics underlying moderate-to-severe asthma risk. Here, we present a whole-genome sequen
Externí odkaz:
https://doaj.org/article/5fa4592260184e79882d694bb0b47a44
Autor:
Zia Khan, Christian Hammer, Jonathan Carroll, Flavia Di Nucci, Sergio Ley Acosta, Vidya Maiya, Tushar Bhangale, Julie Hunkapiller, Ira Mellman, Matthew L. Albert, Mark I. McCarthy, G. Scott Chandler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Endocrinopathies, such as thyroid autoimmunity, are common among patients treated with immune checkpoint inhibitors. Here, by using a polygenic risk score (PRS) derived from a hypothyroidism GWAS, the authors show that cancer patients with high PRS a
Externí odkaz:
https://doaj.org/article/c4d618dc88c448e799c4accf705c951a
Autor:
Robert Brendza, Han Lin, Kimberly Stark, Oded Foreman, Janet Tao, Andrew Pierce, Hai Ngu, Kimberle Shen, Amy E. Easton, Tushar Bhangale, Diana Chang, Baris Bingol, Brad A. Friedman
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105494- (2021)
The gene GPNMB is known to play roles in phagocytosis and tissue repair, and is upregulated in microglia in many mouse models of neurodegenerative disease as well as in human patients. Nearby genomic variants are associated with both elevated Parkins
Externí odkaz:
https://doaj.org/article/97c7b8fae8394304ad382e3b998c63c0
Autor:
Riitta Kaarteenaho, Nina Hautala, Athena Matakidou, Jaakko Kaprio, Ying Wu, Kai Kaarniranta, Peeter Karihtala, Kari Pulkki, Wei Zhou, Caroline Fox, Jussi Pihlajamäki, Apinya Lertratanakul, Juha Paloneva, Johannes Kettunen, Marita Kalaoja, Markus Perola, Veikko Salomaa, Hilkka Soininen, Mika Kähönen, Hao Chen, Andrey Loboda, Soumitra Ghosh, Anders Mälarstig, Markku Laakso, Marja Luodonpää, Markus Juonala, Xing Chen, Marika Crohns, Juhani Junttila, Sirkku Peltonen, Keith Usiskin, Juha Sinisalo, Aarno Palotie, Samuli Ripatti, Oili Kaipiainen-Seppänen, Aki Havulinna, Satu Strausz, Tuomo Kiiskinen, Martin Broberg, Sanni Ruotsalainen, Jukka Koskela, Adel Bachour, Tuula Palotie, Hanna M. Ollila, Mark Daly, Howard Jacob, Heiko Runz, Sally John, Robert Plenge, Mark McCarthy, Julie Hunkapiller, Meg Ehm, Dawn Waterworth, Kathy Klinger, Kathy Call, Tomi Mäkelä, Petri Virolainen, Terhi Kilpi, Jukka Partanen, Anne Pitkäranta, Seppo Vainio, Kimmo Savinainen, Veli-Matti Kosma, Urho Kujala, Outi Tuovila, Minna Hendolin, Raimo Pakkanen, Jeff Waring, States Bridget Riley-Gillis, Jimmy Liu, Shameek Biswas, Dorothee Diogo, Anders Pfizer, Catherine Marshall, Xinli Hu, Matthias Gossel, Johanna Schleutker, Mikko Arvas, Olli Carpen, Reetta Hinttala, Reijo Laaksonen, Arto Mannermaa, Valtteri Julkunen, Anne Remes, Reetta Kälviäinen, Mikko Hiltunen, Jukka Peltola, Pentti Tienari, Juha Rinne, Adam Ziemann, Jeffrey Waring, Sahar Esmaeeli, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Sanni Lahdenperä, John Michon, Geoff Kerchner, Natalie Bowers, Edmond Teng, John Merck, Vinay Mehta, Padhraig Gormley, Kari Linden, Christopher Whelan, Fanli Xu, David Pulford, Martti Färkkilä, Sampsa Pikkarainen, Airi Jussila, Timo Blomster, Mikko Kiviniemi, Markku Voutilainen, Bob Georgantas, Graham Heap, Fedik Rahimov, Joseph Maranville, Tim Lu, Danny Oh, Kirsi Kalpala, Melissa Miller, Linda McCarthy, Kari Eklund, Antti Palomäki, Pia Isomäki, Laura Pirilä, Johanna Huhtakangas, David Close, Marla Hochfeld, Nan Bing, Jorge Esparza Gordillo, Nina Mars, Tarja Laitinen, Margit Pelkonen, Paula Kauppi, Hannu Kankaanranta, Terttu Harju, Steven GreenbergCelgene, Hubert Chen, Jo Betts, Teemu Niiranen, Kaj Metsärinne, Marja-Riitta Taskinen, Tiinamaija Tuomi, Jari Laukkanen, Andrew Peterson Ben Challis, Audrey Chu, Jaakko Parkkinen, Anthony Muslin, Heikki Joensuu, Tuomo Meretoja, Lauri Aaltonen, Annika Auranen, Saila Kauppila, Päivi Auvinen, Klaus Elenius, Relja Popovic, Bridget Riley-Gillis, Jennifer Schutzman, Aparna Chhibber, Heli Lehtonen, Stefan McDonough, Diptee Kulkarni, Joni Turunen, Terhi Ollila, Sanna Seitsonen, Hannu Uusitalo, Vesa Aaltonen, Hannele Uusitalo-Järvinen, Erich Strauss, Anna Podgornaia, Joshua Hoffman, Kaisa Tasanen, Laura Huilaja, Katariina Hannula-Jouppi, Teea Salmi, Leena Koulu, Ilkka Harvima, David Choy, Anu Jalanko, Risto Kajanne, Ulrike Lyhs, Mari Kaunisto, Justin Davis, Danjuma Quarless, Slavé Petrovski, Chia-Yen Chen, Paola Bronson, Robert Yang, Diana Chang, Tushar Bhangale, Emily Holzinger, Xulong Wang, Åsa Hedman, Kirsi Auro, Clarence Wang, Ethan Xu, Franck Auge, Clement Chatelain, Mitja Kurki, Juha Karjalainen, Kimmo Palin, Priit Palta, Pietro Della, Susanna Lemmelä, Manuel Rivas, Jarmo Harju, Arto Lehisto, Andrea Ganna, Vincent Llorens, Antti Karlsson, Kati Kristiansson, Kati Hyvärinen, Jarmo Ritari, Tiina Wahlfors, Miika Koskinen, Katri Pylkäs, Minna Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Sami Heikkinen, Eija Laakkonen, Juha Kononen, Anu Loukola, Päivi Laiho, Tuuli Sistonen, Essi Kaiharju, Markku Laukkanen, Elina Järvensivu, Sini Lähteenmäki, Lotta Männikkö, Regis Wong, Hannele Mattsson, Tero Hiekkalinna, Manuel Jiménez, Kati Donner, Kalle Pärn, Javier Nunez-Fontarnau, Elina Kilpeläinen, Timo Sipilä, Georg Brein, Alexander Dada, Ghazal Awaisa, Anastasia Shcherban, Tuomas Sipilä, Hannele Laivuori, Harri Siirtola, Javier Tabuenca, Lila Kallio, Sirpa Soini, Kimmo Pitkänen, Teijo Kuopio
Publikováno v:
BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)
Background Obstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19.We aimed to study if OSA is an independent risk factor for COVID-19 infecti
Externí odkaz:
https://doaj.org/article/665d58ff79f64fd48408e3fae6e27c75
Autor:
Luz D. Orozco, Hsu-Hsin Chen, Christian Cox, Kenneth J. Katschke, Jr., Rommel Arceo, Carmina Espiritu, Patrick Caplazi, Sarajane Saturnio Nghiem, Ying-Jiun Chen, Zora Modrusan, Amy Dressen, Leonard D. Goldstein, Christine Clarke, Tushar Bhangale, Brian Yaspan, Marion Jeanne, Michael J. Townsend, Menno van Lookeren Campagne, Jason A. Hackney
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1246-1259.e6 (2020)
Summary: Age-related macular degeneration (AMD) is a leading cause of vision loss. To better understand disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we present a comprehensive database of human retina and retinal pigment
Externí odkaz:
https://doaj.org/article/1d550e817e174a2695fd2849cb2c4767
Autor:
Viswanathan Mohan, Venkatesan Radha, Thong T. Nguyen, Eric W. Stawiski, Kanika Bajaj Pahuja, Leonard D. Goldstein, Jennifer Tom, Ranjit Mohan Anjana, Monica Kong-Beltran, Tushar Bhangale, Suresh Jahnavi, Radhakrishnan Chandni, Vijay Gayathri, Paul George, Na Zhang, Sakthivel Murugan, Sameer Phalke, Subhra Chaudhuri, Ravi Gupta, Jingli Zhang, Sam Santhosh, Jeremy Stinson, Zora Modrusan, V. L. Ramprasad, Somasekar Seshagiri, Andrew S. Peterson
Publikováno v:
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Maturity-onset diabetes of the young (MODY) is an early-onset, autosomal dominant form of non-insulin dependent diabetes. Genetic diagnosis of MODY can transform patient management. Earlier data on the genetic predisposition to MO
Externí odkaz:
https://doaj.org/article/d6c8437dec844385a226c2db1c84a725