BFD-22 a new potential inhibitor of BRAF inhibits the metastasis of B16F10 melanoma cells and simultaneously increased the tumor immunogenicity.

Autor: Ferreira AK; Laboratory of Tumor Immunology, University of São Paulo, São Paulo, SP, Brazil; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands. Electronic address: ferreira-kleber@usp.br., Pasqualoto KF; Biochemistry and Biophysics Laboratory, Butantan Institute, São Paulo, SP, Brazil., Kruyt FA; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands., Palace-Berl F; Laboratory of Drug Design and Development, University of São Paulo, São Paulo, SP, Brazil., Azevedo RA; Laboratory of Tumor Immunology, University of São Paulo, São Paulo, SP, Brazil., Turra KM; Laboratory of Cytopathology, Department of Clinical Chemistry and Toxicology, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil., Rodrigues CP; Laboratory of Tumor Immunology, University of São Paulo, São Paulo, SP, Brazil., Ferreira AC; Laboratory of Tumor Immunology, University of São Paulo, São Paulo, SP, Brazil., Salomón MA; Laboratory of Tumor Immunology, University of São Paulo, São Paulo, SP, Brazil., de Sá Junior PL; Laboratory of Genetics, Butantan Institute, São Paulo, SP, Brazil., Farias CF; Experimental Oncology Section, The Federal University of São Paulo, São Paulo, SP, Brazil., Figueiredo CR; Experimental Oncology Section, The Federal University of São Paulo, São Paulo, SP, Brazil., Tavares LC; Laboratory of Drug Design and Development, University of São Paulo, São Paulo, SP, Brazil., Barbuto JA; Laboratory of Tumor Immunology, University of São Paulo, São Paulo, SP, Brazil; Cell and Molecular Therapy Center NUCEL-NETCEM, University of São Paulo, SP, Brazil., Jorge SD; Laboratory of Tumor Immunology, University of São Paulo, São Paulo, SP, Brazil. Electronic address: sdjorge@usp.br.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2016 Mar 15; Vol. 295, pp. 56-67. Date of Electronic Publication: 2016 Feb 10.