TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis

Autor: Mellanby Richard J, Cambrook Helen, Turner Darryl G, O’Connor Richard A, Leech Melanie D, Kurschus Florian C, MacDonald Andrew S, Arnold Bernd, Anderton Stephen M

Publikováno v: Journal of Neuroinflammation, Vol 9, Iss 1, p 248 (2012)

Abstract Background Experimental autoimmune encephalomyelitis (EAE) depends on the initial activation of CD4+ T cells responsive to myelin autoantigens. The key antigen presenting cell (APC) population that drives the activation of naïve T cells mos

Externí odkaz: https://doaj.org/article/7365feb4aef04f5baabaa9f5da48a34c

Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

Autor: Colbeck, Emily J, Hindley, James P, Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C, Turner, Darryl G, Ladell, Kristin, Price, David A, O'Connor, Richard A, Anderton, Stephen M, Godkin, Andrew J, Gallimore, Awen M

Publikováno v: Colbeck, E J, Hindley, J P, Smart, K, Jones, E, Bloom, A, Bridgeman, H, McPherson, R C, Turner, D G, Ladell, K, Price, D A, O'Connor, R A, Anderton, S M, Godkin, A J & Gallimore, A M 2015, ' Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors ', Oncotarget, vol. 6, no. 28, pp. 24649-59 . https://doi.org/10.18632/oncotarget.5584

Foxp3+ regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises largely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6610019ae46174a00831709867bcd476

Methods for Ex Vivo Analysis of Immune Cell Function from the Central Nervous System.

Autor: Turner, Darryl G., Leech, Melanie D., O'Connor, Richard A., Anderton, Stephen M.

Publikováno v: Multiple Sclerosis: Methods & Protocols; 2016, p81-90, 10p

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Methods for Ex Vivo Analysis of Immune Cell Function from the Central Nervous System.

Autor: Turner DG; MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK., Leech MD, O'Connor RA, Anderton SM

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2016; Vol. 1304, pp. 81-90.