Generating CRISPR-Cas9-mediated null mutations and screening targeting efficiency in human pluripotent stem cells

Autor: Bower, Oliver J, McCarthy, Afshan, Lea, Rebecca A, Alanis-Lobato, Gregorio, Zohren, Jasmin, Gerri, Claudia, Turner, James MA, Niakan, Kathy K

CRISPR-Cas9 mutagenesis facilitates the investigation of gene function in a number of developmental and cellular contexts. Human pluripotent stem cells (hPSCs), either embryonic or induced, are a tractable cellular model to investigate molecular mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e3d58cb9567352c155833501625a66

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Autor: Houlihan, Catherine F, Vora, Nina, Byrne, Thomas, Lewer, Dan, Kelly, Gavin, Heaney, Judith, Gandhi, Sonia, Spyer, Moira J, Beale, Rupert, Cherepanov, Peter, Moore, David, Gilson, Richard, Gamblin, Steve, Kassiotis, George, McCoy, Laura E, Swanton, Charles, Hayward, Andrew, Nastouli, Eleni, Aitken, Jim, Allen, Zoe, Ambler, Rachel, Ambrose, Karen, Ashton, Emma, Avola, Alida, Balakrishnan, Samutheswari, Barns-Jenkins, Caitlin, Barr, Genevieve, Barrell, Sam, Basu, Souradeep, Beale, Rupert, Beesley, Clare, Bhardwaj, Nisha, Bibi, Shahnaz, Bineva-Todd, Ganka, Biswas, Dhruva, Blackman, Michael J, Bonnet, Dominique, Bowker, Faye, Broncel, Malgorzata, Brooks, Claire, Buck, Michael D, Buckton, Andrew, Budd, Timothy, Burrell, Alana, Busby, Louise, Bussi, Claudio, Butterworth, Simon, Byrne, Fiona, Byrne, Richard, Caidan, Simon, Campbell, Joanna, Canton, Johnathan, Cardoso, Ana, Carter, Nick, Carvalho, Luiz, Carzaniga, Raffaella, Chandler, Natalie, Chen, Qu, Cherepanov, Peter, Churchward, Laura, Clark, Graham, Clayton, Bobbi, Cobolli Gigli, Clementina, Collins, Zena, Cottrell, Sally, Crawford, Margaret, Cubitt, Laura, Cullup, Tom, Davies, Heledd, Davis, Patrick, Davison, Dara, D'Avola, Annalisa, Dearing, Vicky, Debaisieux, Solene, Diaz-Romero, Monica, Dibbs, Alison, Diring, Jessica, Driscoll, Paul C, Earl, Christopher, Edwards, Amelia, Ekin, Chris, Evangelopoulos, Dimitrios, Faraway, Rupert, Fearns, Antony, Ferron, Aaron, Fidanis, Efthymios, Fitz, Dan, Fleming, James, Frederico, Bruno, Gaiba, Alessandra, Gait, Anthony, Gamblin, Steve, Gandhi, Sonia, Gaul, Liam, Golding, Helen M, Goldman, Jacki, Goldstone, Robert, Gomez Dominguez, Belen, Gong, Hui, Grant, Paul R, Greco, Maria, Grobler, Mariana, Guedan, Anabel, Gutierrez, Maximiliano G, Hackett, Fiona, Hall, Ross, Halldorsson, Steinar, Harris, Suzanne, Hashim, Sugera, Healy, Lyn, Heaney, Judith, Herbst, Susanne, Hewitt, Graeme, Higgins, Theresa, Hindmarsh, Steve, Hirani, Rajnika, Hope, Joshua, Horton, Elizabeth, Hoskins, Beth, Houlihan, Catherine F, Howell, Michael, Howitt, Louise, Hoyle, Jacqueline, Htun, Mint R, Hubank, Michael, Huerga Encabo, Hector, Hughes, Deborah, Hughes, Jane, Huseynova, Almaz, Hwang, Ming-Shih, Instrell, Rachael, Jackson, Deborah, Jamal-Hanjani, Mariam, Jenkins, Lucy, Jiang, Ming, Johnson, Mark, Jones, Leigh, Kanu, Nnennaya, Kassiotis, George, Kiely, Louise, King Spert Teixeira, Anastacio, Kirk, Stuart, Kjaer, Svend, Knuepfer, Ellen, Komarov, Nikita, Kotzampaltiris, Paul, Kousis, Konstantinos, Krylova, Tammy, Kucharska, Ania, Labrum, Robyn, Lambe, Catherine, Lappin, Michelle, Lee, Stacey-Ann, Levett, Andrew, Levett, Lisa, Levi, Marcel, Liu, Hon-Wing, Loughlin, Sam, Lu, Wei-Ting, MacRae, James I, Madoo, Akshay, Marczak, Julie A, Martensson, Mimmi, Martinez, Thomas, Marzook, Bishara, Matthews, John, Matz, Joachim M, McCall, Samuel, McCoy, Laura E, McKay, Fiona, McNamara, Edel C, Minutti, Carlos M, Mistry, Gita, Molina-Arcas, Miriam, Montaner, Beatriz, Montgomery, Kylie, Moore, Catherine, Moore, David, Moraiti, Anastasia, Moreira-Teixeira, Lucia, Mukherjee, Joyita, Naceur-Lombardelli, Cristina, Nastouli, Eleni, Nelson, Aileen, Nicod, Jerome, Nightingale, Luke, Nofal, Stephanie, Nurse, Paul, Nutan, Savita, Oedekoven, Caroline, O'Garra, Anne, O'Leary, Jean D, Olsen, Jessica, O'Neill, Olga, Ordonez Suarez, Paula, O'Reilly, Nicola, Osborne, Neil, Pabari, Amar, Pajak, Aleksandra, Papayannopoulos, Venizelos, Patel, Namita, Patel, Yogen, Paun, Oana, Peat, Nigel, Peces-Barba Castano, Laura, Perez Caballero, Ana, Perez-Lloret, Jimena, Perrault, Magali S, Perrin, Abigail, Poh, Roy, Poirier, Enzo Z, Polke, James M, Pollitt, Marc, Prieto-Godino, Lucia, Proust, Alize, Shah Punatar, Rajvee, Puvirajasinghe, Clinda, Queval, Christophe, Ramachandran, Vijaya, Ramaprasad, Abhinay, Ratcliffe, Peter, Reed, Laura, Reis e Sousa, Caetano, Richardson, Kayleigh, Ridewood, Sophie, Roberts, Rowenna, Rodgers, Angela, Romero Clavijo, Pablo, Rosa, Annachiara, Rossi, Alice, Roustan, Chloe, Rowan, Andrew, Sahai, Erik, Sait, Aaron, Sala, Katarzyna, Sanderson, Theo, Santucci, Pierre, Sardar, Fatima, Sateriale, Adam, Saunders, Jill A, Sawyer, Chelsea, Schlott, Anja, Schweighoffer, Edina, Segura-Bayona, Sandra, Shaw, Joe, Shin, Gee Yen, Silva Dos Santos, Mariana, Silvestre, Margaux, Singer, Matthew, Snell, Daniel M, Song, Ok-Ryul, Spyer, Moira J, Steel, Louisa, Strange, Amy, Sullivan, Adrienne E, Swanton, Charles, Tan, Michele SY, Tautz-Davis, Zoe H, Taylor, Effie, Taylor, Gunes, Taylor, Harriet B, Taylor-Beadling, Alison, Teixeira Subtil, Fernanda, Terré Torras, Berta, Toolan-Kerr, Patrick, Torelli, Francesca, Toteva, Tea, Treeck, Moritz, Trojer, Hadija, Tsai, Ming-Han C, Turner, James MA, Turner, Melanie, Ule, Jernej, Ulferts, Rachel, Vanloo, Sharon P, Veeriah, Selvaraju, Venkatesan, Subramanian, Vousden, Karen, Wack, Andreas, Walder, Claire, Walker, Philip A, Wang, Yiran, Ward, Sophia, Wenman, Catharina, Wiliams, Luke, Williams, Matthew J, Wong, Wai Keong, Wright, Joshua, Wu, Mary, Wynne, Lauren, Xiang, Zheng, Yap, Melvyn, Zagalak, Julian A, Zecchin, Davide, Zillwood, Rachel, Matthews, Rebecca, Severn, Abigail, Adam, Sajida, Enfield, Louise, McBride, Angela, Gärtner, Kathleen, Edwards, Sarah, Lorencatto, Fabiana, Michie, Susan, Manley, Ed, Shahmanesh, Maryam, Lukha, Hinal, Prymas, Paulina, McBain, Hazel, Shortman, Robert, Wood, Leigh, Davies, Claudia, Williams, Bethany, Ng, Kevin W, Cornish, Georgina H, Faulkner, Nikhil, Riddell, Andrew, Hobson, Philip, Agua-Doce, Ana, Bartolovic, Kerol, Russell, Emma, Carr, Lotte, Sanchez, Emilie, Frampton, Daniel, Byott, Matthew, Paraskevopoulou, Stavroula M, Crayton, Elise, Meyer, Carly, Vora, Nina, Gkouleli, Triantafylia, Stoltenberg, Andrea, Ranieri, Veronica, Byrne, Tom, Lewer, Dan, Hayward, Andrew, Gilson, Richard, Kelly, Gavin, Roberts, Fiona, Hatipoglu, Emine

Publikováno v: The Lancet; July 2020, Vol. 396 Issue: 10246 pe6-e7, 2p

Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos

Autor: Afshan McCarthy, Kathy K. Niakan, Gregorio Alanis-Lobato, Dagan Wells, Jasmin Zohren, Maria Greco, Emily Hardman, James M. A. Turner, Norah M. E. Fogarty, N Kubikova

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences

CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles in somatic cells. The use of this approach has also been discussed in the context of heritable editing of the human ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e76a506d5ade59622fead1f539df2f5
https://europepmc.org/articles/PMC8179174/