High-Throughput Screening for Identification of Small Molecule Inhibitors of Histone Acetyltransferases Using Scintillating Microplates (FlashPlate)

Autor: Turlais, F., Hardcastle, Anthea, Rowlands, M., Newbatt, Yvette, Bannister, A., Kouzarides, T., Workman, P., Aherne, G.Wynne

Publikováno v: In Analytical Biochemistry 1 November 2001 298(1):62-68

Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1.

Autor: Mould DP; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester , Wilmslow Road, Manchester, M20 4BX, U.K., Alli C; CRT Discovery Laboratories , Babraham Campus, Babraham, Cambridgeshire CB22 3AT, U.K., Bremberg U; Beactica AB , Uppsala Business Park, Virdings allé 2, 75450, Uppsala, Sweden., Cartic S; CRT Discovery Laboratories , Babraham Campus, Babraham, Cambridgeshire CB22 3AT, U.K., Jordan AM; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester , Wilmslow Road, Manchester, M20 4BX, U.K., Geitmann M; Beactica AB , Uppsala Business Park, Virdings allé 2, 75450, Uppsala, Sweden., Maiques-Diaz A; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, University of Manchester , Wilmslow Road, Manchester, M20 4BX, U.K., McGonagle AE; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester , Wilmslow Road, Manchester, M20 4BX, U.K., Somervaille TCP; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, University of Manchester , Wilmslow Road, Manchester, M20 4BX, U.K., Spencer GJ; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, University of Manchester , Wilmslow Road, Manchester, M20 4BX, U.K., Turlais F; CRT Discovery Laboratories , Babraham Campus, Babraham, Cambridgeshire CB22 3AT, U.K., Ogilvie D; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester , Wilmslow Road, Manchester, M20 4BX, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Oct 12; Vol. 60 (19), pp. 7984-7999. Date of Electronic Publication: 2017 Sep 21.

EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.

Autor: Scheipl S; University College London Cancer Institute, London, UK.; Department of Orthopaedics and Orthopaedic Surgery, Medical University of Graz, Austria., Barnard M; University College London Cancer Institute, London, UK.; Cancer Research Technology Discovery Laboratories, Cambridge, UK.; CRUK-MedImmune Alliance Laboratory, Cambridge, UK., Cottone L; University College London Cancer Institute, London, UK., Jorgensen M; University College London Cancer Institute, London, UK., Drewry DH; GlaxoSmithKline, Research Triangle Park, NC, USA.; SGC-UNC, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA., Zuercher WJ; GlaxoSmithKline, Research Triangle Park, NC, USA.; SGC-UNC, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA., Turlais F; Cancer Research Technology Discovery Laboratories, Cambridge, UK., Ye H; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, UK., Leite AP; University College London Cancer Institute, London, UK., Smith JA; Cancer Research Technology Discovery Laboratories, Cambridge, UK., Leithner A; Department of Orthopaedics and Orthopaedic Surgery, Medical University of Graz, Austria., Möller P; Institute of Pathology, Ulm University, Germany., Brüderlein S; Institute of Pathology, Ulm University, Germany., Guppy N; University College London Advanced Diagnostics, London, UK., Amary F; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, UK., Tirabosco R; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, UK., Strauss SJ; University College London Cancer Institute, London, UK., Pillay N; University College London Cancer Institute, London, UK.; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, UK., Flanagan AM; University College London Cancer Institute, London, UK.; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, UK.; University College London Advanced Diagnostics, London, UK.

Publikováno v: The Journal of pathology [J Pathol] 2016 Jul; Vol. 239 (3), pp. 320-34. Date of Electronic Publication: 2016 May 31.

Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.

Autor: Raoof A; Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, U.K. araoof@picr.man.ac.uk., Depledge P, Hamilton NM, Hamilton NS, Hitchin JR, Hopkins GV, Jordan AM, Maguire LA, McGonagle AE, Mould DP, Rushbrooke M, Small HF, Smith KM, Thomson GJ, Turlais F, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2013 Aug 22; Vol. 56 (16), pp. 6352-70. Date of Electronic Publication: 2013 Jul 31.

High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma.

Autor: Ajay, Amrendra K.^1,2 (AUTHOR) akajay@bwh.harvard.edu, Chu, Philip¹ (AUTHOR), Patel, Poojan^1,2 (AUTHOR), Deban, Christa¹ (AUTHOR), Roychowdhury, Chitran¹ (AUTHOR), Heda, Radhika¹ (AUTHOR), Halawi, Ahmad^1,2 (AUTHOR), Saad, Anis^1,2 (AUTHOR), Younis, Nour^1,2 (AUTHOR), Zhang, Hao³ (AUTHOR), Jiang, Xiuju³ (AUTHOR), Nasr, Mahmoud^1,2 (AUTHOR), Hsiao, Li-Li^1,2 (AUTHOR), Lin, Gang³ (AUTHOR), Azzi, Jamil R.^1,2 (AUTHOR) akajay@bwh.harvard.edu

Publikováno v: Pharmaceutics. Apr2023, Vol. 15 Issue 4, p1274. 18p.