Synthesis of novel benzothiazole-piperazine derivatives and their biological evaluation as acetylcholinesterase inhibitors and cytotoxic agents

Autor: Gurdal, E.E., Turgutalp, B., Gulcan, H.O., Erçetin, T., Sahin, M.F., Durmaz, I., Yarim, M.

Objective and Method: A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10007::f3d323210cc35d2f97054df515dbb98b
https://hdl.handle.net/20.500.11831/2479

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Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents.

Autor: Gurdal EE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, 34755, Kayisdagi, Istanbul. Turkey., Turgutalp B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, 34755, Kayisdagi, Istanbul. Turkey., Gulcan HO; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta. Cyprus., Ercetin T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta. Cyprus., Sahin MF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta. Cyprus., Durmaz I; Bioinformatics Department, Graduate School of Informatics, Middle East Technical University, Ankara. Turkey., Atalay RC; Bioinformatics Department, Graduate School of Informatics, Middle East Technical University, Ankara. Turkey., Nguyen QD; Martin-Luther- Universität Halle-Wittenberg, Institute of Pharmacy, Medicinal Chemistry Department, Halle (Saale). Germany., Sippl W; Martin-Luther- Universität Halle-Wittenberg, Institute of Pharmacy, Medicinal Chemistry Department, Halle (Saale). Germany., Yarim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, 34755, Kayisdagi, Istanbul. Turkey.

Publikováno v: Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2017; Vol. 17 (13), pp. 1837-1845.