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In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure exacerbates urinary dysfunction in hormone-treated C57BL/6J mice through a non-malignant mechanism involving proteomic changes in the prostate that differ from those elicited by testosterone and estradiol

Autor: Turco, Anne E, Thomas, Samuel, Crawford, LaTasha K, Tang, Weiping, Peterson, Richard E, Li, Lingjun, Ricke, William A, Vezina, Chad M

A recent study directed new focus on the fetal and neonatal environment as a risk factor for urinary dysfunction in aging males. Male mice were exposed in utero and via lactation (IUL) to the persistent environmental contaminant 2,3,7,8-tetrachlorodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a3391b6eed610042372580e81a1b540
https://europepmc.org/articles/PMC7076297/

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Genetic background but not prostatic epithelial beta-catenin influences susceptibility of male mice to testosterone and estradiol-induced urinary dysfunction.

Autor: Wegner KA; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA.; Molecular and Environmental Toxicology Center, University of Wisconsin-Madison Madison, Wisconsin 53706, USA., Ruetten H; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA., Girardi NM; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA., O'Driscoll CA; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA., Sandhu JK; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA., Turco AE; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA.; Molecular and Environmental Toxicology Center, University of Wisconsin-Madison Madison, Wisconsin 53706, USA., Abler LL; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA., Wang P; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA., Wang Z; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA., Bjorling DE; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA., Malinowski R; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Pharmacy, University of Wisconsin-Madison Madison, WI, USA., Peterson RE; School of Pharmacy, University of Wisconsin-Madison Madison, WI, USA., Strand DW; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; Department of Urology, University of Texas Southwestern Medical Center Dallas, Texas, USA., Marker PC; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Pharmacy, University of Wisconsin-Madison Madison, WI, USA., Vezina CM; University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison Madison, Wisconsin 53706, USA.; Molecular and Environmental Toxicology Center, University of Wisconsin-Madison Madison, Wisconsin 53706, USA.

Publikováno v: American journal of clinical and experimental urology [Am J Clin Exp Urol] 2021 Feb 15; Vol. 9 (1), pp. 121-131. Date of Electronic Publication: 2021 Feb 15 (Print Publication: 2021).