An integrated multi-omics approach identifies the landscape of interferon-alpha-mediated responses of human pancreatic beta cells

Autor: Colli, ML, Ramos-Rodriguez, M, Nakayasu, ES, Alvelos, MI, Lopes, M, Hill, JLE, Turatsinze, JV, de Brachene, AC, Russell, MA, Raurell-Vila, H, Castela, A, Juan-Mateu, J, Webb-Robertson, BJM, Krogvold, L, Dahl-Jorgensen, K, Marselli, L, Marchetti, P, Richardson, SJ, Morgan, NG, Metz, TO, Pasquali, L, Eizirik, DL

Publikováno v: Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Interferon-alpha (IFN alpha), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. We presently character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::08a6134a36824c962a0804088d6471ba
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3359

An integrated multi-omics approach identifies the type I interferon-induced signature of human beta cells

Autor: Colli, ML, Nakayasu, ES, Ramos-Rodriguez, M, Turatsinze, JV, de Brachene, AC, Lopes, M, dos Santos, RS, Juan-Mateu, J, Raurell-Vila, H, Scharfmann, R, Marchetti, P, Pasquali, L, Metz, TO, Eizirik, DL

Publikováno v: Diabetologia
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::567948d225b71f2e24b0f79157b4faf4
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6260

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

Autor: Quesada T, Cereijo R, Turatsinze JV, Planavila A, Cairo M, Gavalda A, Peyrou M, Moure R, Iglesias R, Giralt M, Eizirik DL, Villarroya F

Publikováno v: NATURE COMMUNICATIONS
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

The thermogenic activity of brown adipose tissue (BAT) and browning of white adipose tissue are important components of energy expenditure. Here we show that GPR120, a receptor for polyunsaturated fatty acids, promotes brown fat activation. Using RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::015dcf6d9efcfa95dee0bf3cf4cc8d72
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10830

TIGER: The gene expression regulatory variation landscape of human pancreatic islets.

Autor: Alonso L; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Piron A; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium; Interuniversity Institute of Bioinformatics in Brussels (IB2), Brussels 1050, Belgium., Morán I; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Guindo-Martínez M; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Bonàs-Guarch S; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Barcelona 08013, Spain., Atla G; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Barcelona 08013, Spain., Miguel-Escalada I; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Barcelona 08013, Spain., Royo R; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Puiggròs M; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Garcia-Hurtado X; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Barcelona 08013, Spain., Suleiman M; Department of Clinical and Experimental Medicine and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Marselli L; Department of Clinical and Experimental Medicine and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Esguerra JLS; Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Malmö 214 28, Sweden., Turatsinze JV; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., Torres JM; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK., Nylander V; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK., Chen J; Exeter Centre of Excellence for Diabetes Research (EXCEED), University of Exeter Medical School, Exeter EX4 4PY, UK., Eliasson L; Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Malmö 214 28, Sweden., Defrance M; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., Amela R; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Mulder H; Unit of Molecular Metabolism, Lund University Diabetes Centre, Malmö 214 28, Sweden., Gloyn AL; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK; Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94304, USA; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford OX3 7DQ, UK; Stanford Diabetes Research Centre, Stanford University, Stanford, CA 94305, USA., Groop L; Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Malmö 214 28, Sweden; Unit of Molecular Metabolism, Lund University Diabetes Centre, Malmö 214 28, Sweden; Finnish Institute of Molecular Medicine Finland (FIMM), Helsinki University, Helsinki 00014, Finland., Marchetti P; Department of Clinical and Experimental Medicine and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Eizirik DL; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium; WELBIO, Université Libre de Bruxelles, Brussels 1050, Belgium., Ferrer J; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Barcelona 08013, Spain; Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London SW7 2AZ, UK., Mercader JM; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: mercader@broadinstitute.org., Cnop M; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium; Division of Endocrinology, Erasmus Hospital, Université Libre de Bruxelles, Brussels 1070, Belgium. Electronic address: mcnop@ulb.ac.be., Torrents D; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain. Electronic address: david.torrents@bsc.es.

Publikováno v: Cell reports [Cell Rep] 2021 Oct 12; Vol. 37 (2), pp. 109807.

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

Autor: Marselli L; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy. Electronic address: lorella.marselli@med.unipi.it., Piron A; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., Suleiman M; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Colli ML; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., Yi X; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., Khamis A; INSERM UMR 1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille University Hospital, Lille 59000, France., Carrat GR; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Imperial College, London, UK., Rutter GA; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Imperial College, London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Bugliani M; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Giusti L; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy; School of Pharmacy, University of Camerino, Camerino, Italy., Ronci M; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, Chieti, Italy; Centre for Advanced Studies and Technologies (CAST), University 'G. d'Annunzio' of Chieti-Pescara, Chieti, Italy., Ibberson M; Vital-IT Group, Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland., Turatsinze JV; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., Boggi U; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa 56126, Italy; Division of General and Transplant Surgery, Cisanello University Hospital, Pisa 56124, Italy., De Simone P; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa 56126, Italy; Division of Liver Surgery and Transplantation, Cisanello University Hospital, Pisa 56124, Italy., De Tata V; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa 56126, Italy., Lopes M; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., Nasteska D; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., De Luca C; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Tesi M; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Bosi E; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Singh P; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., Campani D; Department of Surgical, Medical and Molecular Pathology and the Critical Areas, University of Pisa, Pisa 56126, Italy., Schulte AM; Sanofi-Aventis Deutschland GmbH, Diabetes Research, Frankfurt, Germany., Solimena M; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital Carl Gustav Carus and Faculty of Medicine, TU Dresden, Dresden 01307, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg 85764, Germany., Hecht P; Sanofi-Aventis Deutschland GmbH, Diabetes Research, Frankfurt, Germany., Rady B; Janssen RDUS, Philadelphia, PA, USA., Bakaj I; Janssen RDUS, Philadelphia, PA, USA., Pocai A; Janssen RDUS, Philadelphia, PA, USA., Norquay L; Janssen RDUS, Philadelphia, PA, USA., Thorens B; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Canouil M; INSERM UMR 1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille University Hospital, Lille 59000, France., Froguel P; Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, UK., Eizirik DL; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium; WELBIO, Université Libre de Bruxelles, Brussels, Belgium; Indiana Biosciences Research Institute, Indianapolis, IN, USA; Division of Endocrinology, ULB Erasmus Hospital, Université Libre de Bruxelles, Brussels, Belgium., Cnop M; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium; Division of Endocrinology, ULB Erasmus Hospital, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: mcnop@ulb.ac.be., Marchetti P; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy. Electronic address: piero.marchetti@med.unipi.it.

Publikováno v: Cell reports [Cell Rep] 2020 Dec 01; Vol. 33 (9), pp. 108466.