An integrated multi-omics approach identifies the landscape of interferon-alpha-mediated responses of human pancreatic beta cells

Autor: Colli, ML, Ramos-Rodriguez, M, Nakayasu, ES, Alvelos, MI, Lopes, M, Hill, JLE, Turatsinze, JV, de Brachene, AC, Russell, MA, Raurell-Vila, H, Castela, A, Juan-Mateu, J, Webb-Robertson, BJM, Krogvold, L, Dahl-Jorgensen, K, Marselli, L, Marchetti, P, Richardson, SJ, Morgan, NG, Metz, TO, Pasquali, L, Eizirik, DL

Publikováno v: Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Interferon-alpha (IFN alpha), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. We presently character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::08a6134a36824c962a0804088d6471ba
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3359

An integrated multi-omics approach identifies the type I interferon-induced signature of human beta cells

Autor: Colli, ML, Nakayasu, ES, Ramos-Rodriguez, M, Turatsinze, JV, de Brachene, AC, Lopes, M, dos Santos, RS, Juan-Mateu, J, Raurell-Vila, H, Scharfmann, R, Marchetti, P, Pasquali, L, Metz, TO, Eizirik, DL

Publikováno v: Diabetologia
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::567948d225b71f2e24b0f79157b4faf4
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6260

TIGER: The gene expression regulatory variation landscape of human pancreatic islets.

Autor: Alonso L; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Piron A; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium; Interuniversity Institute of Bioinformatics in Brussels (IB2), Brussels 1050, Belgium., Morán I; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Guindo-Martínez M; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Bonàs-Guarch S; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Barcelona 08013, Spain., Atla G; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Barcelona 08013, Spain., Miguel-Escalada I; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Barcelona 08013, Spain., Royo R; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Puiggròs M; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Garcia-Hurtado X; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Barcelona 08013, Spain., Suleiman M; Department of Clinical and Experimental Medicine and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Marselli L; Department of Clinical and Experimental Medicine and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Esguerra JLS; Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Malmö 214 28, Sweden., Turatsinze JV; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., Torres JM; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK., Nylander V; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK., Chen J; Exeter Centre of Excellence for Diabetes Research (EXCEED), University of Exeter Medical School, Exeter EX4 4PY, UK., Eliasson L; Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Malmö 214 28, Sweden., Defrance M; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium., Amela R; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain., Mulder H; Unit of Molecular Metabolism, Lund University Diabetes Centre, Malmö 214 28, Sweden., Gloyn AL; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK; Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94304, USA; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford OX3 7DQ, UK; Stanford Diabetes Research Centre, Stanford University, Stanford, CA 94305, USA., Groop L; Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Malmö 214 28, Sweden; Unit of Molecular Metabolism, Lund University Diabetes Centre, Malmö 214 28, Sweden; Finnish Institute of Molecular Medicine Finland (FIMM), Helsinki University, Helsinki 00014, Finland., Marchetti P; Department of Clinical and Experimental Medicine and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy., Eizirik DL; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium; WELBIO, Université Libre de Bruxelles, Brussels 1050, Belgium., Ferrer J; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Barcelona 08013, Spain; Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London SW7 2AZ, UK., Mercader JM; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: mercader@broadinstitute.org., Cnop M; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium; Division of Endocrinology, Erasmus Hospital, Université Libre de Bruxelles, Brussels 1070, Belgium. Electronic address: mcnop@ulb.ac.be., Torrents D; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona 08034, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain. Electronic address: david.torrents@bsc.es.

Publikováno v: Cell reports [Cell Rep] 2021 Oct 12; Vol. 37 (2), pp. 109807.

A novel proteomics approach to epigenetic profiling of circulating nucleosomes.

Autor: Van den Ackerveken P; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium., Lobbens A; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium., Turatsinze JV; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium., Solis-Mezarino V; EpiQMAx GmbH, Am Klopferspitz 19, 82152, Planegg-Martinsried, Germany., Völker-Albert M; EpiQMAx GmbH, Am Klopferspitz 19, 82152, Planegg-Martinsried, Germany., Imhof A; EpiQMAx GmbH, Am Klopferspitz 19, 82152, Planegg-Martinsried, Germany., Herzog M; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium. M.Herzog@volition.com.

Publikováno v: Scientific reports [Sci Rep] 2021 Mar 31; Vol. 11 (1), pp. 7256. Date of Electronic Publication: 2021 Mar 31.

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.

Autor: Syed F; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Tersey SA; Kovler Diabetes Center and Department of Medicine, The University of Chicago, 900 E. 57th Street, KCBD-8130, Chicago, IL, 60637, USA., Turatsinze JV; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium., Felton JL; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Kang NJ; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Nelson JB; Kovler Diabetes Center and Department of Medicine, The University of Chicago, 900 E. 57th Street, KCBD-8130, Chicago, IL, 60637, USA., Sims EK; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Defrance M; Laboratory for Cancer Epigenetics, Faculty of Medicine, and ULB Cancer Research Center, Université Libre de Bruxelles, Brussels, Belgium., Bizet M; Laboratory for Cancer Epigenetics, Faculty of Medicine, and ULB Cancer Research Center, Université Libre de Bruxelles, Brussels, Belgium., Fuks F; Laboratory for Cancer Epigenetics, Faculty of Medicine, and ULB Cancer Research Center, Université Libre de Bruxelles, Brussels, Belgium., Cnop M; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.; Division of Endocrinology (ULB Erasmus Hospital), Université Libre de Bruxelles, Brussels, Belgium., Bugliani M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Marchetti P; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Ziegler AG; Technische Universität München, Munich, Germany., Bonifacio E; Technische Universität Dresden, Dresden, Germany., Webb-Robertson BJ; Pacific Northwest National Laboratory, Richland, WA, USA., Balamurugan AN; Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Department of Surgery, University of Cincinnati, Cincinnati, OH, 45229, USA., Evans-Molina C; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.; Roudebush VA Medical Center, Indianapolis, IN, USA., Eizirik DL; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.; Indiana Biosciences Research Institute, Indianapolis, IN, USA., Mather KJ; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Arslanian S; Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Mirmira RG; Kovler Diabetes Center and Department of Medicine, The University of Chicago, 900 E. 57th Street, KCBD-8130, Chicago, IL, 60637, USA. mirmira@uchicago.edu.

Publikováno v: Clinical epigenetics [Clin Epigenetics] 2020 Jul 31; Vol. 12 (1), pp. 116. Date of Electronic Publication: 2020 Jul 31.