The polymorphic variant of SerpinB3 (SerpinB3-PD) is associated with faster cirrhosis decompensation.

Autor: Martini A; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy., Turato C; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Cannito S; Unit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy., Quarta S; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy., Biasiolo A; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy., Ruvoletto M; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy., Novo E; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Marafatto F; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy., Guerra P; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy., Tonon M; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy., Clemente N; Department of Health Science, Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy., Bocca C; Unit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy., Piano SS; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy., Guido M; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy., Gregori D; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova, Padova, Italy., Parola M; Unit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy., Angeli P; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy., Pontisso P; Unit of Internal Medicine and Hepatology, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.; European Reference Network - ERN RARE-LIVER, Department of Medicine, Azienda Ospedaliera-Università, Padova, Italy.

Publikováno v: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2024 Feb; Vol. 59 (3), pp. 380-392. Date of Electronic Publication: 2023 Nov 21.

The protease activated receptor 2 - CCAAT/enhancer-binding protein beta - SerpinB3 axis inhibition as a novel strategy for the treatment of non-alcoholic steatohepatitis.

Autor: Villano G; Dept. of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Italy., Novo E; Dept. of Clinical and Biological Sciences, University of Torino, Italy., Turato C; Dept. of Molecular Medicine, University of Pavia, Italy., Quarta S; Dept. of Medicine, University of Padova, Italy., Ruvoletto M; Dept. of Medicine, University of Padova, Italy., Biasiolo A; Dept. of Medicine, University of Padova, Italy., Protopapa F; Dept. of Clinical and Biological Sciences, University of Torino, Italy., Chinellato M; Dept. of Medicine, University of Padova, Italy., Martini A; Dept. of Medicine, University of Padova, Italy., Trevellin E; Dept. of Medicine, University of Padova, Italy., Granzotto M; Dept. of Medicine, University of Padova, Italy., Cannito S; Dept. of Clinical and Biological Sciences, University of Torino, Italy., Cendron L; Dept. of Biology, University of Padova, Italy., De Siervi S; Dept. of Molecular Medicine, University of Pavia, Italy., Guido M; Dept. of Medicine, University of Padova, Italy., Parola M; Dept. of Clinical and Biological Sciences, University of Torino, Italy., Vettor R; Dept. of Medicine, University of Padova, Italy., Pontisso P; Dept. of Medicine, University of Padova, Italy. Electronic address: patrizia@unipd.it.

Publikováno v: Molecular metabolism [Mol Metab] 2024 Mar; Vol. 81, pp. 101889. Date of Electronic Publication: 2024 Feb 01.

Hepatocellular Carcinoma: Latest Research in Pathogenesis, Detection and Treatment.

Autor: Foglia B; Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy., Turato C; Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy., Cannito S; Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Jul 31; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 31.

Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease

Autor: Turato, C., Ruvoletto, M.G., Biasiolo, A., Quarta, S., Tono, N., Bernardinello, E., Beneduce, L., Fassina, G., Cavalletto, L., Chemello, L., Merkel, C., Gatta, A., Pontisso, P.

Publikováno v: In Digestive and Liver Disease 2009 41(3):212-216

SerpinB3 Upregulates Low-Density Lipoprotein Receptor-Related Protein (LRP) Family Members, Leading to Wnt Signaling Activation and Increased Cell Survival and Invasiveness.

Autor: Quarta S; Department of Medicine, University of Padova, 35128 Padua, Italy., Cappon A; Department of Medicine, University of Padova, 35128 Padua, Italy., Turato C; Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy., Ruvoletto M; Department of Medicine, University of Padova, 35128 Padua, Italy., Cannito S; Department of Clinical and Biological Sciences, University of Torino, 10124 Turin, Italy., Villano G; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, 35128 Padua, Italy., Biasiolo A; Department of Medicine, University of Padova, 35128 Padua, Italy., Maggi M; Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy., Protopapa F; Department of Clinical and Biological Sciences, University of Torino, 10124 Turin, Italy., Bertazza L; Department of Medicine, University of Padova, 35128 Padua, Italy., Fasolato S; Department of Medicine, University of Padova, 35128 Padua, Italy., Parola M; Department of Clinical and Biological Sciences, University of Torino, 10124 Turin, Italy., Pontisso P; Department of Medicine, University of Padova, 35128 Padua, Italy.

Publikováno v: Biology [Biology (Basel)] 2023 May 26; Vol. 12 (6). Date of Electronic Publication: 2023 May 26.