Restoration of Noradrenergic Function in Parkinson’s Disease Model Mice

Autor: Kui Cui, Fan Yang, Turan Tufan, Muhammad U. Raza, Yanqiang Zhan, Yan Fan, Fei Zeng, Russell W. Brown, Jennifer B. Price, Thomas C. Jones, Gary W. Miller, Meng-Yang Zhu

Publikováno v: ASN Neuro, Vol 13 (2021)

Dysfunction of the central noradrenergic and dopaminergic systems is the primary neurobiological characteristic of Parkinson’s disease (PD). Importantly, neuronal loss in the locus coeruleus (LC) that occurs in early stages of PD may accelerate pro

Externí odkaz: https://doaj.org/article/211b67322f2c43e6b811583451534260

CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response

Autor: Karol Szlachta, Cem Kuscu, Turan Tufan, Sara J. Adair, Stephen Shang, Alex D. Michaels, Matthew G. Mullen, Natasha Lopes Fischer, Jiekun Yang, Limin Liu, Prasad Trivedi, Edward B. Stelow, P. Todd Stukenberg, J. Thomas Parsons, Todd W. Bauer, Mazhar Adli

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Predicting the response to chemotherapy is a major goal of cancer research. Here the authors use CRISPR knockout screens in pancreatic ductal adenocarcinoma cells to identify deletions synergistic with MEK inhibitors.

Externí odkaz: https://doaj.org/article/5878576fa2b34029942f52a332a9c423

Supplementary Data from Chemotherapy-Induced Distal Enhancers Drive Transcriptional Programs to Maintain the Chemoresistant State in Ovarian Cancer

Autor: Mazhar Adli, Peter C. Scacheri, Analisa Difeo, Charles N. Landen, Tarek Abbas, Philip J. Ebert, Robert M. Campbell, Inyoung Lee, Fadila Guessous, Mouadh Benamar, Natasha Lopes Fischer, Turan Tufan, Alexander James Duval, Amir A. Jazaeri, Jiekun Yang, Stephen Shang

Supplementary Figures S1-2,4, describe cell viability curves of tested cell lines. Figure S3 and S5 show bioinformatic data for resistance upregulated gene sets (S3) and cisplatin-taxane comparison analysis(S5). Figure S6 shows ECAR and OCR experimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d356fc6183b02b85b38fc3cf4f861a0e
https://doi.org/10.1158/0008-5472.22422177.v1

Pannexin 1 drives efficient epithelial repair after tissue injury

Autor: Christopher D. Lucas, Christopher B. Medina, Finnius A. Bruton, David A. Dorward, Michael H. Raymond, Turan Tufan, J. Iker Etchegaray, Brady Barron, Magdalena E. M. Oremek, Sanja Arandjelovic, Emily Farber, Suna Onngut-Gumuscu, Eugene Ke, Moira K. B. Whyte, Adriano G. Rossi, Kodi S. Ravichandran

Publikováno v: SCIENCE IMMUNOLOGY
Lucas, C D, Medina, C B, Bruton, F, Dorward, D, Raymond, M H, Tufan, T, Etchegaray, J I, Barron, B, Oremek, M, Arandjelovic, S, Farber, E, Onngut-Gumuscu, S, Ke, E, Whyte, M K B, Rossi, A G & Ravichandran, K S 2022, ' Pannexin 1 drives efficient epithelial repair after tissue injury ', Science Immunology, vol. 7, no. 71, eabm4032 . https://doi.org/10.1126/sciimmunol.abm4032

Epithelial tissues such as lung and skin are exposed to the environment and therefore particularly vulnerable to damage during injury or infection. Rapid repair is therefore essential to restore function and organ homeostasis. Dysregulated epithelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b391a65e38300beccab46d3723b79a
https://pubmed.ncbi.nlm.nih.gov/35559667

Differential regulation of diabetes-induced rat aorta ATP-sensitive potassium channels, Kir 6.1 and Kir 6.2, by pulsed magnetic field therapy

Autor: Mehmet Bertan Yilmaz, Isil Ocal, Eylul Akbal, Tufan Mert, Turan Tufan, Gamze Comertpay, Nermin Seda Ilgaz, Ozgur Turgut, Inayet Nur Uslu

Publikováno v: Çukurova Üniversitesi Tıp Fakültesi Dergisi, Vol 38, Iss 1, Pp 15-21 (2013)

Purpose: Our goal is to determine the effects of pulsed field magnetic field treatment (PMF), which has been reported to lower blood cholesterol, glucose, triglyceride levels and recover vascular defects of diabetic rats, on ATP-sensitive potassium c

Externí odkaz: https://doaj.org/article/fcafef70d0164181b3c553dd0475a842