Aconitum and Delphinium alkaloids : “Drug-likeness” descriptors related to toxic mode of action

Autor: Turabekova, Malakhat A., Rasulev, Bakhtiyor F., Dzhakhangirov, Farkhad N., Salikhov, Shavkat I.

Publikováno v: In Environmental Toxicology and Pharmacology 2008 25(3):310-320

Aconitum and Delphinium sp. Alkaloids as Antagonist Modulators of Voltage-Gated Na+ Channels. AM1/DFT Electronic Structure Investigations and QSAR Studies

Autor: Turabekova, Malakhat A., Rasulev, Bakhtiyor F., Levkovich, Mikhail G., Abdullaev, Nasrulla D., Leszczynski, Jerzy

Early pharmacological studies of Aconitum and Delphinium sp. alkaloids suggested that these neurotoxins act at site 2 of voltage-gated Na(+) channel and allosterically modulate its function. Understanding structural requirements for these compounds t

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https://europepmc.org/articles/PMC5001567/

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A QSAR toxicity study of a series of alkaloids with the lycoctonine skeleton.

Autor: Turabekova MA; Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Kh. Abdullaev Str., 77, Tashkent, 700170, Uzbekistan. malohathon@yahoo.com, Rasulev BF

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2004 Dec 31; Vol. 9 (12), pp. 1194-207. Date of Electronic Publication: 2004 Dec 31.