Výsledky vyhledávání

Novel PSCA targeting scFv-fusion proteins for diagnosis and immunotherapy of prostate cancer

Autor: Kessler, C., Pardo, A., Tur, M.K., Gattenlöhner, S., Fischer, R., Kolberg, K., Barth, S.

Purpose Despite great progress in the diagnosis and treatment of localized prostate cancer (PCa), there remains a need for new diagnostic markers that can accurately distinguish indolent and aggressive variants. One promising approach is the antibody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::0282fcc08925265106cd6a26b48e6d82
https://publica.fraunhofer.de/handle/publica/252064

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Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein

Autor: Brehm, H., Hristodorov, D., Pardo, A., Mladenov, R., Niesen, J., Fischer, R., Tur, M.K., Barth, S.

The treatment of rhabdomyosarcoma (RMS) is challenging, and the prognosis remains especially poor for high-grade RMS with metastasis. The conventional treatment of RMS is based on multi-agent chemotherapy combined with resection and radiotherapy, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::a94538ba00e0230fc0137cfb8844d857
https://publica.fraunhofer.de/handle/publica/240843

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In vitro effects and ex vivo binding of an EGFR-specific immunotoxin on rhabdomyosarcoma cells

Autor: Niesen, J., Brehm, H., Stein, C., Berges, N., Pardo, A., Fischer, R., Haaf, A. ten, Gattenlöhner, S., Tur, M.K., Barth, S.

PURPOSE: Rhabdomyosarcoma (RMS) is a rare and aggressive soft tissue sarcoma with limited treatment options and a high failure rate during standard therapy. New therapeutic strategies based on targeted immunotherapy are therefore much in demand. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::2d246a88c6e75c3595639f583e6b54d9
https://publica.fraunhofer.de/handle/publica/238857

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SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells

Autor: Hussain, A.F., Kampmeier, F., Felbert, V. von, Merk, H.F., Tur, M.K., Barth, S.

Cancer cells can be killed by photosensitizing agents that induce toxic effects when exposed to nonhazardous light, but this also causes significant damage to surrounding healthy cells. The specificity of photodynamic therapy can be increased by conj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::7c5a28d2f0278598129e0eef67846fae
https://publica.fraunhofer.de/handle/publica/227168

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Generation of recombinant antibody fragments that target canine dendritic cells by phage display technology

Autor: Fitting, J., Killian, D., Junghanss, C., Willenbrock, S., Murua Escobar, H., Lange, S., Nolte, I., Barth, S., Tur, M.K.

One of the main goals in cancer immunotherapy is the efficient activation of the host immune system against tumour cells. Dendritic cells (DCs) can induce specific anti-tumour immune responses in both experimental animal models and humans. However, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::d2dd258e2b05193eccf827f9c3aee0e5
https://publica.fraunhofer.de/handle/publica/226456

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In vivo efficacy of the recombinant anti-CD64 immunotoxin H22(scFv)-ETA in a human acute myeloid leukemia xenograft tumor model

Autor: Tur, M.K., Huhn, M., Jost, E., Thepen, T., Brümmendorf, T.H., Barth, S.

Target-specific acute myeloid leukemia (AML) immunotherapy requires selective cell-surface antigens on AML blast cells. CD64 is a promising candidate antigen because it is abundantly expressed on monocytoid differentiated AML subtypes. In previous st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::a0973f9aed30b924f3417fdd42c9e8ee
https://publica.fraunhofer.de/handle/publica/226494

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Recombinant, ETA'-based CD64 immunotoxins: Improved efficacy by increased valency, both in vitro and in vivo in a chronic cutaneous inflammation model in human CD64 transgenic mice

Autor: Ribbert, T., Thepen, T., Tur, M.K., Fischer, R., Huhn, M., Barth, S.

Background Dysregulated, activated macrophages play a pivotal role in chronic inflammatory diseases such as arthritis and atopic dermatitis. These cells display increased expression of the high-affinity Fc gamma receptor (CD64), making them ideal tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::643bafce7b8a304e90ebe40481503b5d
https://publica.fraunhofer.de/handle/publica/222399

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Fc gamma receptor 1 (CD64), a target beyond cancer

Autor: Thepen, T., Huhn, M., Melmer, G., Tur, M.K., Barth, S.

Immunotoxins are powerful tools to specifically eliminate deviated cells. Due to the side effects of the original immunotoxins, they were only considered for the treatment of cancer as in these cases, the potential favourable effect outweighed the un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::6e3c50df7b3e357df33209671146aa99
https://publica.fraunhofer.de/handle/publica/219162

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