Successful In Situ Targeting of Pancreatic Tumors in a Novel Orthotopic Porcine Model Using Histotripsy.

Autor: Imran KM; Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, USA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Gannon J; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA., Morrison HA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Tupik JD; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Tintera B; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA; Virginia Tech Carilion School of Medicine, Roanoke, VA, USA., Nagai-Singer MA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Ivester H; Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, USA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Madanick JM; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Hendricks-Wenger A; Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, USA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA; DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Knoxville, TN, USA., Uh K; Division of Animal Science, College of Agriculture Food and Natural Resources, University of Missouri, Columbia, MO, USA., Luyimbazi DT; Department of Surgery, Carilion Clinic and Virginia Tech Carilion School of Medicine, Roanoke, VA, USA., Edwards M; Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Coutermarsh-Ott S; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Eden K; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Byron C; Department of Large Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Clark-Deener S; Department of Large Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA., Lee K; Division of Animal Science, College of Agriculture Food and Natural Resources, University of Missouri, Columbia, MO, USA., Vlaisavljevich E; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA., Allen IC; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA. Electronic address: icallen@vt.edu.

Publikováno v: Ultrasound in medicine & biology [Ultrasound Med Biol] 2023 Nov; Vol. 49 (11), pp. 2361-2370. Date of Electronic Publication: 2023 Aug 16.

Improved Therapeutic Delivery Targeting Clinically Relevant Orthotopic Human Pancreatic Tumors Engrafted in Immunocompromised Pigs Using Ultrasound-Induced Cavitation: A Pilot Study.

Autor: Imran KM; Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA 24061, USA.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA., Tintera B; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA., Morrison HA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA., Tupik JD; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA., Nagai-Singer MA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA., Ivester H; Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA 24061, USA., Council-Troche M; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA., Edwards M; Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA., Coutermarsh-Ott S; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA., Byron C; Department of Large Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA., Clark-Deener S; Department of Large Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA., Uh K; Division of Animal Science, College of Agriculture Food and Natural Resources, University of Missouri, Columbia, MO 65211, USA., Lee K; Division of Animal Science, College of Agriculture Food and Natural Resources, University of Missouri, Columbia, MO 65211, USA., Boulos P; OxSonics Therapeutics, Oxford Science Park, Oxford OX4 4GA, UK., Rowe C; OxSonics Therapeutics, Oxford Science Park, Oxford OX4 4GA, UK., Coviello C; OxSonics Therapeutics, Oxford Science Park, Oxford OX4 4GA, UK., Allen IC; Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA 24061, USA.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA.

Publikováno v: Pharmaceutics [Pharmaceutics] 2023 May 24; Vol. 15 (6). Date of Electronic Publication: 2023 May 24.

Detecting DNA: An Overview of DNA Recognition by Inflammasomes and Protection against Bacterial Respiratory Infections.

Autor: Tupik JD; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA., Markov Madanick JW; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA., Ivester HM; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA., Allen IC; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.; Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA 24016, USA.

Publikováno v: Cells [Cells] 2022 May 19; Vol. 11 (10). Date of Electronic Publication: 2022 May 19.

To protect or adversely affect? The dichotomous role of the NLRP1 inflammasome in human disease.

Autor: Tupik JD; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA., Nagai-Singer MA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA., Allen IC; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA, USA. Electronic address: icallen@vt.edu.

Publikováno v: Molecular aspects of medicine [Mol Aspects Med] 2020 Dec; Vol. 76, pp. 100858. Date of Electronic Publication: 2020 Apr 28.

Using Computer-based Image Analysis to Improve Quantification of Lung Metastasis in the 4T1 Breast Cancer Model.

Autor: Nagai-Singer MA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine., Hendricks-Wenger A; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine; Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University., Brock RM; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine; Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University., Morrison HA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine., Tupik JD; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine., Coutermarsh-Ott S; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine., Allen IC; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine; Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University; Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Virginia Polytechnic Institute and State University; icallen@vt.edu.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2020 Oct 02 (164). Date of Electronic Publication: 2020 Oct 02.