Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tuomas Ryhänen"'
Autor:
Kati Juuti-Uusitalo, Hanna Vaajasaari, Tuomas Ryhänen, Susanna Narkilahti, Riitta Suuronen, Eliisa Mannermaa, Kai Kaarniranta, Heli Skottman
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30089 (2012)
Retinal pigment epithelial (RPE) cells in the back of the eye nourish photoreceptor cells and form a selective barrier that influences drug transport from the blood to the photoreceptor cells. At the molecular level, ATP-dependent efflux transporters
Externí odkaz:
https://doaj.org/article/01feea986ab446cc8d26bbee2bce55c8
Autor:
Iiris Sorri, Tuomas Paimela, Kai Kaarniranta, Johanna Viiri, Antero Salminen, Tuomas Ryhänen, Elisa Toropainen, Juha M.T. Hyttinen
Publikováno v:
Scopus-Elsevier
The pathogenesis of age-related macular degeneration (AMD) essentially involves chronic oxidative stress, increased accumulation of lipofuscin in retinal pigment epithelial (RPE) cells and extracellular drusen formation, as well as the presence of ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1291b1528aa4229c854f06b963f9c88
https://doi.org/10.2741/e198
https://doi.org/10.2741/e198
Autor:
Veli-Pekka Ranta, Kai Kaarniranta, Kati-Sisko Vellonen, Arto Urtti, Eliisa Mannermaa, Katriina Kokkonen, Tuomas Ryhänen
Publikováno v:
Pharmaceutical Research. 26:1785-1791
The objective of this study was to characterize efflux proteins (P-glycoprotein (P-gp), multidrug resistance proteins (MRP1–6) and breast cancer resistance protein (BCRP)) of retinal pigment epithelium (RPE) cell lines. Expression of efflux protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0e6ba973a5fa0a013f459757ab9950
https://doi.org/10.1007/s11095-009-9890-6
https://doi.org/10.1007/s11095-009-9890-6
Autor:
Tuomas Ryhänen, Antero Salminen, Tuomas Paimela, Kai Kaarniranta, Eliisa Mannermaa, Giedrius Kalesnykas, Johanna Ojala
Publikováno v:
Immunology Letters. 110:139-144
Toll-like receptors (TLRs) and inflammatory cascades participate in the pathology of age-related macular degeneration (AMD). The effect of estrogens on the development of AMD is poorly understood, although many studies indicate that these compounds c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83642d4d1da9f3588e8b5a4775c2ec4b
https://doi.org/10.1016/j.imlet.2007.04.008
https://doi.org/10.1016/j.imlet.2007.04.008
Autor:
Mika A. Elo, Markku Teräsvirta, Mikko J. Lammi, Kai Kaarniranta, Tiina Suuronen, Antero Salminen, Reijo Sironen, Hannu Uusitalo, Tuomas Ryhänen, Hannu M. Karjalainen
Publikováno v:
Molecular Brain Research. 137:126-131
Reversible protein phosphorylation regulates the biological activities of many human proteins involved in crucial cellular processes, e.g., protein-protein interactions, cell signaling, gene transcription, cell growth, and death. A malfunction of cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687187562b0ae47142d1b58b335a7cbe
https://doi.org/10.1016/j.molbrainres.2005.02.027
https://doi.org/10.1016/j.molbrainres.2005.02.027
Autor:
Mika Reinisalo, Kai Kaarniranta, Ro Karjalainen, Tuomas Paimela, Ali Koskela, Tuomas Ryhänen, T Soininen, Anu Kauppinen
Publikováno v:
Acta Ophthalmologica. 90
Purpose Oxidative stress is related to chronic diseases including age-related macular degeneration (AMD), which is the leading cause of blindness in the elderly worldwide. Functional roles of wood-derived phenolic compounds such as flavonoids, phenol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31f20c9c30f80feabd98cfe240dc7d32
https://doi.org/10.1111/j.1755-3768.2012.4266.x
https://doi.org/10.1111/j.1755-3768.2012.4266.x
Autor:
Tuomas, Paimela, Tuomas, Ryhänen, Anu, Kauppinen, Liisa, Marttila, Antero, Salminen, Kai, Kaarniranta
Publikováno v:
Molecular Vision
Purpose In numerous clinical and experimental studies, preservatives present in eye drops have had detrimental effects on ocular epithelial cells. The aim of this study was to compare the cytotoxic and inflammatory effects of the preservative polyqua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97832c7440f4014675d556da0e326b95
https://pubmed.ncbi.nlm.nih.gov/22605930
https://pubmed.ncbi.nlm.nih.gov/22605930
Autor:
Susanna Narkilahti, Hanna Vaajasaari, Kai Kaarniranta, Kati Juuti-Uusitalo, Eliisa Mannermaa, Tuomas Ryhänen, Heli Skottman, Riitta Suuronen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 1, p e30089 (2012)
PLoS ONE, Vol 7, Iss 1, p e30089 (2012)
Retinal pigment epithelial (RPE) cells in the back of the eye nourish photoreceptor cells and form a selective barrier that influences drug transport from the blood to the photoreceptor cells. At the molecular level, ATP-dependent efflux transporters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63147eaa0ddedc9b9ac3b82f9cca452b
http://europepmc.org/articles/PMC3260202
http://europepmc.org/articles/PMC3260202
Autor:
Tuomas Ryhänen, Giedrius Kalesnykas, Jooseppi Puranen, K. Vehanen, T. Tuulos, H Uusitalo, Kai Kaarniranta
Publikováno v:
Acta Ophthalmologica. 89
Purpose To examine heat shock protein (HSP) expression in retinas of mice that lack brain derived neurotrophic factor (BDNF+/-) and their wild type littermates (WT) at young and old age. Methods Eyes from 2- and 22-months old WT and BDNF+/- mice (The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98304028831519b64407885d32c84e40
https://doi.org/10.1111/j.1755-3768.2011.207.x
https://doi.org/10.1111/j.1755-3768.2011.207.x
Autor:
Goran Petrovski, Tuomas Paimela, Kai Kaarniranta, Juha M.T. Hyttinen, S Akhtar, Johanna Viiri, Nicoletta Marchesi, Marialaura Amadio, Antero Salminen, Tuomas Ryhänen, Alessia Pascale
Publikováno v:
Acta Ophthalmologica. 89
Purpose The pathogenesis of age-related macular degeneration involves impaired protein degradation in retinal pigment epithelial (RPE) cells. The ubiquitin-proteasome pathway and the lysosomal pathway including autophagy are the major proteolytic sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd6419a94605c3205d7c6fd0b934bb07
https://doi.org/10.1111/j.1755-3768.2011.2136.x
https://doi.org/10.1111/j.1755-3768.2011.2136.x