Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tuomas A. Tolvanen"'
Autor:
Maria Koivisto, Tuomas A. Tolvanen, Tarja Toimela, Ilkka Miinalainen, Antti Kiviaho, Juha Kesseli, Matti Nykter, Lauri Eklund, Tuula Heinonen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC) are widely used in in vitro biomedical research and testing. However, fully matured, adult cardiomyocyte characteristics have not been achieved. To improve the maturity
Externí odkaz:
https://doaj.org/article/e91a2ccd543946a4a1e74761627a9c6c
Autor:
Mika E. A. Berg, Jette-Britt Naams, Laura C. Hautala, Tuomas A. Tolvanen, Jari P. Ahonen, Sanna Lehtonen, Kristiina Wähälä
Publikováno v:
ACS Omega, Vol 5, Iss 3, Pp 1430-1438 (2020)
Externí odkaz:
https://doaj.org/article/032aa932cb734a2ebf45e493a806158d
Autor:
Pauliina Saurus, Tuomas A. Tolvanen, Sonja Lindfors, Sara Kuusela, Harry Holthöfer, Eero Lehtonen, Sanna Lehtonen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Lack of CD2-associated protein (CD2AP) in mice increases podocyte apoptosis and leads to glomerulosclerosis and renal failure. We showed previously that SHIP2, a negative regulator of the PI3K/AKT signalling pathway, interacts with CD2AP. He
Externí odkaz:
https://doaj.org/article/d18126741d1541cb94450899dbf983bc
Autor:
Tuomas Aleksi Tolvanen, Jette-Britt Naams, Kristiina Wähälä, Mika Erik Anthon Berg, Sanna Lehtonen, Jari Ahonen, Laura Hautala
Publikováno v:
ACS Omega, Vol 5, Iss 3, Pp 1430-1438 (2020)
ACS Omega
ACS Omega
A series of substituted sulfonanilide analogs were prepared and evaluated as novel potent inhibitors of SH2 domaincontaining inositol polyphosphate 5′-phosphatase 2 (SHIP2). SHIP2 has been shown to be a new attractive target for the treatment of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71dd20c3a3c3e24ab366166062218152
https://doaj.org/article/032aa932cb734a2ebf45e493a806158d
https://doaj.org/article/032aa932cb734a2ebf45e493a806158d
Autor:
Tuomas Aleksi, Tolvanen
Publikováno v:
Frontiers in molecular biosciences. 9
Knowing that the drug candidate binds to its intended target is a vital part of drug discovery. Thus, several labeled and label-free methods have been developed to study target engagement. In recent years, the cellular thermal shift assay (CETSA) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a11e4c02610a5ef7c4e06664db437102
https://pubmed.ncbi.nlm.nih.gov/35755818
https://pubmed.ncbi.nlm.nih.gov/35755818
Autor:
Zydrune, Polianskyte-Prause, Tuomas A, Tolvanen, Sonja, Lindfors, Kanta, Kon, Laura C, Hautala, Hong, Wang, Tsutomu, Wada, Hiroshi, Tsuneki, Toshiyasu, Sasaoka, Sanna, Lehtonen
Publikováno v:
International journal of biological sciences. 18(5)
Ebselen, a multifunctional organoselenium compound, has been recognized as a potential treatment for diabetes-related disorders. However, the underlying mechanisms whereby ebselen regulates metabolic pathways remain elusive. We discovered that ebsele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::851cb6792e3401caf42cf10b7be2a31e
https://pubmed.ncbi.nlm.nih.gov/35342343
https://pubmed.ncbi.nlm.nih.gov/35342343
Autor:
Sonja Lindfors, Mervi Van, Per-Henrik Groop, Jukka Tienari, Tuomas Aleksi Tolvanen, Mika Erik Anthon Berg, Sanna Lehtonen, Vincent Dumont, Tuomas Mirtti, Hong Wang, Surjya Narayan Dash, Harry Nisen, Laura Hautala, Kristiina Wähälä, Jette-Britt Naams, Zydrune Polianskyte-Prause
Publikováno v:
The FASEB Journal
Metformin, the first-line drug to treat type 2 diabetes (T2D), inhibits mitochondrial glycerolphosphate dehydrogenase in the liver to suppress gluconeogenesis. However, the direct target and the underlying mechanisms by which metformin increases gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba4d832c677d60eb1972136fc7e88be
https://doi.org/10.1096/fj.201800529rr
https://doi.org/10.1096/fj.201800529rr
Autor:
Sara Kuusela, Pauliina Saurus, Tuomas Aleksi Tolvanen, Eero Lehtonen, Harry Holthöfer, Sonja Lindfors, Sanna Lehtonen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
Lack of CD2-associated protein (CD2AP) in mice increases podocyte apoptosis and leads to glomerulosclerosis and renal failure. We showed previously that SHIP2, a negative regulator of the PI3K/AKT signalling pathway, interacts with CD2AP. Here, we fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a258c0414a6870e60a7b2e6f714f2cb1
https://doaj.org/article/d18126741d1541cb94450899dbf983bc
https://doaj.org/article/d18126741d1541cb94450899dbf983bc
Autor:
Harry Nisen, Vincent Dumont, Hiroshi Kawachi, Shiro Suetsugu, Sanna Lehtonen, Jukka Tienari, Sara Kuusela, Hong Wang, Tuula A. Nyman, Markus Plomann, Sonja Lindfors, Tuomas Aleksi Tolvanen
Publikováno v:
The FASEB Journal
Nephrin is a core component of podocyte (glomerular epithelial cell) slit diaphragm and is required for kidney ultrafiltration. Down-regulation or mislocalization of nephrin has been observed in diabetic kidney disease (DKD), characterized by albumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6831c5eaf988f315d43aabc021eb42ec
http://europepmc.org/articles/PMC5572687
http://europepmc.org/articles/PMC5572687
Autor:
Antti Mäkitie, Petri S. Mattila, Reidar Grénman, Tuomas Aleksi Tolvanen, Lauri Jouhi, Jaana Hagström, Anna Kaisa Kylmä, Timo Carpén, Caj Haglund, Sanna Lehtonen, Timo Sorsa
Publikováno v:
Experimental and Molecular Pathology. 114:104435
In oropharyngeal squamous cell carcinoma (OPSCC), the expression pattern of toll-like receptors (TLRs), in comparison between human papillomavirus (HPV)-positive and -negative tumors differs. TLRs control innate immune responses by activating, among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2319faa749cf5efd8797c954b49fb731
https://doi.org/10.1016/j.yexmp.2020.104435
https://doi.org/10.1016/j.yexmp.2020.104435