Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tung-Ti Chen"'
Publikováno v:
Molecular and Cellular Biology. 24:4438-4447
Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine that coordinates the systemic response to infection and injury. TNF-α interacts with two types of cell surface receptors (types I and II) to regulate various cell-type-specific respons
Autor:
Tung-Ti Chen, Jean Y. J. Wang
Publikováno v:
Molecular and Cellular Biology. 20:5571-5580
The crystal structure of the A-B domain of RB has defined the binding pocket for the LXCXE peptide motif. Using the crystal structure as a guide, we have inactivated the LXCXE-binding pocket by replacing N757 with Phe [to obtain RB(N757F)]. RB(N757F)
Autor:
Yen-Ying Ma, Wen-Hwa Lee, Wen-Hai Chou, Yumay Chen, Kai-Hsuan Chang, Teresa L. Yang-Feng, Ming-Jer Tsai, Xiaohua Leng, Tung-Ti Chen, Bert W. O'Malley, Phang Lang Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 94:9040-9045
The retinoblastoma protein (Rb) plays a critical role in cell proliferation, differentiation, and development. To decipher the mechanism of Rb function at the molecular level, we have systematically characterized a number of Rb-interacting proteins,
Publikováno v:
Journal of Biological Chemistry. 269:28450-28459
We have shown previously that a 300-base pair (bp) 5' upstream sequence of rabbit keratin K3 gene (RK3) can function as a keratinocyte-specific promoter in transient transfection assays. Electrophoretic mobility shift assays using various overlapping
Publikováno v:
Molecular biology of the cell. 16(3)
cAMP exerts an antiproliferative effect on a number of cell types including lymphocytes. This effect of cAMP is proposed to be mediated by its ability to inhibit G1/S transition. In this report, we provide evidence for a new mechanism whereby cAMP mi
Publikováno v:
Acta oncologica (Stockholm, Sweden). 40(6)
Growth arrest induced by DNA damage in mammalian cells requires the function of the retinoblastoma tumor suppressor protein (RB). RB-deficient cells cannot undergo G1, mid-S or G2 arrest following DNA damage, although they can activate the G2 checkpo
Publikováno v:
Genesdevelopment. 12(15)
The retinoblastoma tumor suppressor protein, RB, is a negative regulator of cell proliferation. Growth inhibitory activity of RB is attenuated by phosphorylation. Mutation of a combination of phosphorylation sites leads to a constitutively active RB.
Publikováno v:
Molecular & Cellular Biology; May2004, Vol. 24 Issue 10, p4438-4447, 10p, 4 Color Photographs, 21 Black and White Photographs, 1 Diagram, 15 Graphs
Autor:
Chau, B. Nelson, Borges, Helena Lobo, Tung-Ti Chen, Masselli, Anja, Hunton, Irina C., Wang, Jean Y.J.
Publikováno v:
Nature Cell Biology; Oct2002, Vol. 4 Issue 10, p757, 9p
Autor:
Pier Lorenzo Puri, Larry Kedes, Vittorio Sartorelli, Peter Stiegler, Tung Ti Chen, George E.O. Muscat, Simona Iezzi, Jean Y. J. Wang, R. Louis Schiltz, Antonio Giordano
Publikováno v:
ResearcherID
Università degli Studi di Siena-IRIS
Università degli Studi di Siena-IRIS
We describe a functional and biochemical link between the myogenic activator MyoD, the deacetylase HDAC1, and the tumor suppressor pRb. Interaction of MyoD with HDAC1 in undifferentiated myoblasts mediates repression of muscle-specific gene expressio
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