Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Tung M. Fong"'
Autor:
Pranela Remeshwar, Susan E. Leeman, Christa Y. Heyward, Tung M. Fong, Steven D. Douglas, Erin Dombrowsky, Joseph Coulson, Brenden Canning, Jeffrey Barrett
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Tachykinin receptors (provisional nomenclature as recommended by NC-IUPHAR [91]) are activated by the endogenous peptides substance P (SP), neurokinin A (NKA; previously known as substance K, neurokinin α, neuromedin L), neurokinin B (NKB; previousl
Autor:
Jarl E. S. Wikberg, Jeffrey B. Tatro, Helgi Schiöth, Colin Pouton, Kathleen G. Mountjoy, Victor J. Hruby, Carrie Haskell-Luevano, Ira Gantz, Tung M. Fong, Sadaf Farooqi, Alex N. Eberle, Roger D. Cone, Adrian J. L. Clark, Biao-Xin Chai, Vanni Caruso
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous anta
Autor:
Helgi B. Schiöth, Alex N. Eberle, Sadaf Farooqi, Biaoxin Chai, Roger D. Cone, Colin W. Pouton, Jeffrey B. Tatro, Vanni Caruso, Jarl E. S. Wikberg, Adrian J. L. Clark, Tung M. Fong, Carrie Haskell-Luevano, Victor J. Hruby, Kathleen G. Mountjoy, Ira Gantz
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous anta
Autor:
Erin Dombrowsky, Jeffrey S. Barrett, Steven D. Douglas, Joseph Coulson, Pranela Remeshwar, Brenden Canning, Tung M. Fong, Christa Y. Heyward, Susan E. Leeman
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Tachykinin receptors (provisional nomenclature as recommended by NC-IUPHAR [90]) are activated by the endogenous peptides substance P (SP), neurokinin A (NKA; previously known as substance K, neurokinin α, neuromedin L), neurokinin B (NKB; previousl
Autor:
Steven B. Heymsfield, Amy O. Johnson-Levonas, Susan Nicolich, Alison M. Strack, Tung M. Fong, Joana Achanfuo-Yeboah, Donald Thompson, P Cunningham, G. J. Hickey, Donald F. Hora, Terry D. Faidley
Publikováno v:
Metabolism. 61:546-553
Pharmacologic inhibition of the cannabinoid-1 receptor (CB1R) in rodent models leads to weight loss and time-dependent changes in energy balance. This study evaluated the effects of CB1R inhibition on weight loss, energy expenditure (EE), and food in
Autor:
Palucki Brenda, Patrick G. Pollard, Liangqin Guo, Tung M. Fong, Matthew J. Wyvratt, Randy R. Miller, Shuwen He, Constantin Tamvakopoulos, Iyassu K. Sebhat, Qianping Peng, Ravi P. Nargund, Zhixiong Ye, Airu S. Chen, Doreen E. Cashen, David H. Weinberg, Min K. Park, Raman K. Bakshi, D. Euan MacIntyre, Howard Y. Chen, Rui Tang, Tanya MacNeil, Qingmei Hong, Alison M. Strack, Ralph A. Stearns, Jian Liu, William J. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2330-2334
We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.
Autor:
Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4399-4405
We report a series of potent and selective MC4R agonists based on spiroindane amide privileged structures for potential treatments of obesity. Among the synthetic methods used, Method C allows rapid synthesis of the analogs. The series of compounds c
Autor:
Laurie G. Castonguay, Sookhee Ha, Lex H.T. Van der Ploeg, Chun-Pyn Shen, Ihor E. Kopka, Zhege J. Lao, Mark T. Goulet, Linus S. Lin, William K. Hagmann, Tung M. Fong, James P. Jewell, Thomas J. Lanza
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4757-4761
The design, synthesis, and binding activity of ring constrained analogs of the acyclic cannabinoid-1 receptor (CB1R) inverse agonist taranabant 1 are described. The initial inspiration for these taranabant derivatives was its conformation 1a, determi
Autor:
Tung M. Fong, John R. Thompson, Wenqing Zhao, Drew T. Weingarth, Olivia Fong, Eric S. Muise, Su Qian
Publikováno v:
Molecular Pharmacology. 78:350-359
Inhibition of cannabinoid receptor 1 (CB1) has shown efficacy in reducing body weight and improving metabolic parameters, with the effects correlating with target engagement in the brain. The peripheral effects of inhibiting the CB1 receptor has been
Autor:
Junying Wang, Richard G. Ball, Chun-Pyn Shen, Richard Z. Chen, Julie Lao, Vijay Bhasker G. Reddy, Xinchun Tong, Jeffrey J. Hale, Alison M. Strack, Jing Chen Xiao, Lauren P. Shearman, John S. Debenham, Tung M. Fong, D. Sloan Stribling, Christina B. Madsen-Duggan, Pei Huo, Lin Yan, Nancy N. Tsou, Thomas Bateman
Publikováno v:
Journal of Medicinal Chemistry. 53:4028-4037
This paper describes the discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596, 12c) as a novel cannabinoid-1 receptor (CB1R) inverse agonist