Výsledky vyhledávání - "Tunde Akinyeke"

Akademický článek

Effects of Sub-Chronic MPTP Exposure on Behavioral and Cognitive Performance and the Microbiome of Wild-Type and mGlu8 Knockout Female and Male Mice

Autor: Eileen Ruth S. Torres, Tunde Akinyeke, Keaton Stagaman, Robert M. Duvoisin, Charles K. Meshul, Thomas J. Sharpton, Jacob Raber

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 12 (2018)

Motor dysfunction is a hallmark of Parkinson’s disease (PD); however, non-motor symptoms such as gastrointestinal dysfunction often arise prior to motor symptoms. Alterations in the gut microbiome have been proposed as the earliest event in PD path

Externí odkaz: https://doaj.org/article/e153347db2c2458595b6d751665cc3ed

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Akademický článek

The PPAR Gamma Agonist Troglitazone Regulates Erk 1/2 Phosphorylation via a PPARγ-Independent, MEK-Dependent Pathway in Human Prostate Cancer Cells

Autor: Adrienne Bolden, Lynikka Bernard, Danielle Jones, Tunde Akinyeke, LaMonica V. Stewart

Publikováno v: PPAR Research, Vol 2012 (2012)

Thiazolidinediones (TZDs) dramatically reduce the growth of human prostate cancer cells in vitro and in vivo. To determine whether the antitumor effects of TZDs were due in part to changes in the MEK/Erk signaling pathway, we examined the regulation

Externí odkaz: https://doaj.org/article/2fcd54810502460bbfb52ba44e109896

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Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice

Autor: Eileen Ruth S. Torres, Tunde Akinyeke, Jacob Raber, Armando Alcazar Magana, Lisa Lione, Claudia S. Maier, Jaewoo Choi, Jan F. Stevens, Michael Ouanesisouk, Bayissi Bading-Taika, Gerd Bobe, Cristobal L. Miranda

Publikováno v: Journal of Food Bioactives. 3:111-123

Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal alkaloid of T. iboga, ibogaine, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a10cf1bde386d4eb8d2434afd0d53ee
https://doi.org/10.31665/jfb.2018.3154

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Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response

Autor: Esha M. Patel, Sydney Weber Boutros, Lance A. Johnson, Jacob Raber, Eileen Ruth S. Torres, Nabil J. Alkayed, Tunde Akinyeke

Publikováno v: Journal of Cerebral Blood Flow & Metabolism

Metabolic dysfunction, commonly a result of diets high in saturated fats and sugar, is associated with impaired cognitive function and an increased risk of age-related cognitive decline (ACD) and Alzheimer’s disease (AD). Compared to the E3 isoform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c4bf86145418b7b63f857687cff523
https://doi.org/10.1177/0271678x17746186

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Paradoxical effects of 137Cs irradiation on pharmacological stimulation of reactive oxygen species in hippocampal slices from apoE2 and apoE4 mice

Autor: Laura Villasana, Sydney Weber, Jacob Raber, Tunde Akinyeke

Publikováno v: Oncotarget

// Laura E. Villasana 1 , Tunde Akinyeke 1 , Sydney Weber 1 and Jacob Raber 1, 2 1 Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, USA 2 Departments of Neurology and Radiation Medicine, Division

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13e967f33453365cb8a13c5ce8ee165
https://doi.org/10.18632/oncotarget.20603

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Enhanced cued fear memory following post-training whole body irradiation of 3-month-old mice

Autor: Reid H.J. Olsen, Jacob Raber, Tunde Akinyeke, Sydney Weber

Publikováno v: Behavioural Brain Research. 319:181-187

Typically, in studies designed to assess effects of irradiation on cognitive performance the animals are trained and tested for cognitive function following irradiation. Little is known about post-training effects of irradiation on cognitive performa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0355917c70a3bc1056361defcbc6aa
https://doi.org/10.1016/j.bbr.2016.11.031

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Genotype differences in anxiety and fear learning and memory of WT and ApoE4 mice associated with enhanced generation of hippocampal reactive oxygen species

Autor: Jacob Raber, Sydney Weber, Tunde Akinyeke, Laura Villasana

Publikováno v: Journal of Neurochemistry. 138:896-908

Apolipoprotein E (apoE), involved in cholesterol and lipid metabolism, also influences cognitive function and injury repair. In humans, apoE is expressed in three isoforms. E4 is a risk factor for age-related cognitive decline and Alzheimer's disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2b60dbb1825430a4180b26382359b7
https://doi.org/10.1111/jnc.13737

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Ion mobility-enhanced MSE-based label-free analysis reveals effects of low-dose radiation post contextual fear conditioning training on the mouse hippocampal proteome

Autor: Samanthi Wickramasekara, Claudia S. Maier, Lin Huang, Tunde Akinyeke, Blair S. Stewart, Yuan Jiang, Jacob Raber

Publikováno v: Journal of Proteomics. 140:24-36

Recent advances in the field of biodosimetry have shown that the response of biological systems to ionizing radiation is complex and depends on the type and dose of radiation, the tissue(s) exposed, and the time lapsed after exposure. The biological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ce8b19aca0638cca501b0eda943de8
https://doi.org/10.1016/j.jprot.2016.03.032

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Detrimental Effects of Helium Ion Irradiation on Cognitive Performance and Cortical Levels of MAP-2 in B6D2F1 Mice

Autor: Sydney Weber Boutros, Tunde Akinyeke, Jacob Raber, Eileen Ruth S. Torres, Joanne Lee, Amy Kronenberg, Mitchell S. Turker

Publikováno v: International journal of molecular sciences, vol 19, iss 4
International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 1247
Raber, J; Torres, ERS; Akinyeke, T; Lee, J; Weber Boutros, SJ; Turker, MS; et al.(2018). Detrimental effects of helium ion irradiation on cognitive performance and cortical levels of MAP-2 in B6D2F1 mice. International Journal of Molecular Sciences, 19(4). doi: 10.3390/ijms19041247. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/8t430581
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1247 (2018)

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. The space radiation environment includes helium (4He) ions that may impact brain function. As little is known about the effects of exposures to4He ions on the brain, we assessed the behaviora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27928f4a05c9fd0ca395312495c9c31
https://escholarship.org/uc/item/8t430581

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Metformin targets c-MYC oncogene to prevent prostate cancer

Autor: Satoko Matsumura, Anjana Saxena, Eric D. Schalfer, Susan K. Logan, Yingjie Wu, Tunde Akinyeke, Wenbo Yan, Xinying Wang, Xin Li

Publikováno v: Carcinogenesis. 34:2823-2832

Prostate cancer (PCa) is the second leading cause of cancer-related death in American men and many PCa patients develop skeletal metastasis. Current treatment modalities for metastatic PCa are mostly palliative with poor prognosis. Epidemiological st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e3bbbd90e6a378ed4d8fde6b74e932
https://doi.org/10.1093/carcin/bgt307

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