Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Tuncay, Baubec"'
Autor:
Nina Schmolka, Ino D. Karemaker, Richard Cardoso da Silva, Davide C. Recchia, Vincent Spegg, Jahnavi Bhaskaran, Michael Teske, Nathalie P. de Wagenaar, Matthias Altmeyer, Tuncay Baubec
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The Nucleosome Remodeling and Deacetylation (NuRD) complex is a crucial regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be integral, but mutually exclusive
Externí odkaz:
https://doaj.org/article/66c7c83fa81b49c2b95f6c7642a549d4
Autor:
Francisco Caiado, Diogo Maia-Silva, Carolina Jardim, Nina Schmolka, Tânia Carvalho, Cláudia Reforço, Rita Faria, Branka Kolundzija, André E. Simões, Tuncay Baubec, Christopher R. Vakoc, Maria Gomes da Silva, Markus G. Manz, Ton N. Schumacher, Håkan Norell, Bruno Silva-Santos
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The development of post-chemotherapy resistance is a significant issue in the management of AML. Here, Caiado et al. suggest that the issue might be circumvented via upfront combination with hypomethylating agents that shape the clonal dynamics and t
Externí odkaz:
https://doaj.org/article/b7dfc820cd8046b7b9099018be4d92e6
Autor:
Ino D. Karemaker, Tuncay Baubec
Publikováno v:
Swiss Medical Weekly, Vol 150, Iss 3536 (2020)
DNA methylation is an epigenetic modification that plays a central regulatory role in various biological processes. Methyl groups are coupled to cytosines by the family of DNA methyltransferases (DNMTs), where DNMT1 is the main maintenance enzyme and
Externí odkaz:
https://doaj.org/article/5024fddca96a498e98b1bed5278ab548
Autor:
Kyoko Hiragami-Hamada, Szabolcs Soeroes, Miroslav Nikolov, Bryan Wilkins, Sarah Kreuz, Carol Chen, Inti A. De La Rosa-Velázquez, Hans Michael Zenn, Nils Kost, Wiebke Pohl, Aleksandar Chernev, Dirk Schwarzer, Thomas Jenuwein, Matthew Lorincz, Bastian Zimmermann, Peter Jomo Walla, Heinz Neumann, Tuncay Baubec, Henning Urlaub, Wolfgang Fischle
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Heterochromatin protein 1 (HP1), including HP1 α, β and γ, is a family of non-histone chromatin factors thought to be involved in chromatin organization. Here, the authors show that dimeric HP1β interacts dynamically with H3K9me3, a hallmark of h
Externí odkaz:
https://doaj.org/article/daad9f601a9746829955629c5cc1bf39
Autor:
Francisco Caiado, Diogo Maia-Silva, Carolina Jardim, Nina Schmolka, Tânia Carvalho, Cláudia Reforço, Rita Faria, Branka Kolundzija, André E. Simões, Tuncay Baubec, Christopher R. Vakoc, Maria Gomes da Silva, Markus G. Manz, Ton N. Schumacher, Håkan Norell, Bruno Silva-Santos
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/b8f06182e119402593d473bfdd9813b5
Publikováno v:
PLoS Genetics, Vol 13, Iss 12, p e1007102 (2017)
Genomic location can inform on potential function and recruitment signals for chromatin-associated proteins. High mobility group (Hmg) proteins are of similar size as histones with Hmga1 and Hmga2 being particularly abundant in replicating normal tis
Externí odkaz:
https://doaj.org/article/330fb0cedc414b0f99aee51ed792af9e
Autor:
Vincent Dion, Alicia C. Borgeaud, Marcela Buřičová, Cinzia Cinesi, Bin Yang, Tuncay Baubec, Alysha S Taylor, Gustavo A. Ruiz Buendía, Lorène Aeschbach, Oscar Rodriguez-Lima
Publikováno v:
Human molecular genetics, vol. 31, no. 3, pp. 386-398
Expanded CAG/CTG repeat disorders affect over 1 in 2500 individuals worldwide. Potential therapeutic avenues include gene silencing and modulation of repeat instability. However, there are major mechanistic gaps in our understanding of these processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d614fc2feb2061840a5f176703ab1134
https://orca.cardiff.ac.uk/id/eprint/143789/4/ddab255.pdf
https://orca.cardiff.ac.uk/id/eprint/143789/4/ddab255.pdf
Autor:
Nina Schmolka, Maria Gomes da Silva, Tânia Carvalho, Carolina Jardim, Håkan Norell, Bruno Silva-Santos, Francisco Caiado, Ton N. Schumacher, Branka Kolundzija, Cláudia Reforço, Rita Faria, Diogo Maia-Silva, Tuncay Baubec, Christopher R. Vakoc, André E. Simões, Markus G. Manz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Chemotherapy-resistant cancer recurrence is a major cause of mortality. In acute myeloid leukemia (AML), chemorefractory relapses result from the complex interplay between altered genetic, epigenetic and transcriptional states in leukemic cells. Here
Autor:
Major, Philipp Voigt, Christos Spanos, Elana Bryan, Juri Rappsilber, Warburton M, Katy A. Mclaughlin, Tuncay Baubec, Kimberly M. Webb, Christina Ambrosi
SummaryPromoters of developmental genes in embryonic stem cells (ESCs) are marked by histone H3 lysine 4 trimethylation (H3K4me3) and H3K27me3 in an asymmetric nucleosomal conformation, with each sister histone H3 carrying only one mark. These bivale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63771db91072f6bbd0a8540cf4a013f5
https://doi.org/10.1101/2021.02.08.430127
https://doi.org/10.1101/2021.02.08.430127
Autor:
Izaskun, Mallona, Ioana Mariuca, Ilie, Ino Dominiek, Karemaker, Stefan, Butz, Massimiliano, Manzo, Amedeo, Caflisch, Tuncay, Baubec
Publikováno v:
Nucleic Acids Research
Mammalian de novo DNA methyltransferases (DNMT) are responsible for the establishment of cell-type-specific DNA methylation in healthy and diseased tissues. Through genome-wide analysis of de novo methylation activity in murine stem cells we uncover