Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Tunç Morova"'
Autor:
Jeroen Kneppers, Tesa M. Severson, Joseph C. Siefert, Pieter Schol, Stacey E. P. Joosten, Ivan Pak Lok Yu, Chia-Chi Flora Huang, Tunç Morova, Umut Berkay Altıntaş, Claudia Giambartolomei, Ji-Heui Seo, Sylvan C. Baca, Isa Carneiro, Eldon Emberly, Bogdan Pasaniuc, Carmen Jerónimo, Rui Henrique, Matthew L. Freedman, Lodewyk F. A. Wessels, Nathan A. Lack, Andries M. Bergman, Wilbert Zwart
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Epigenetic reprogramming of the androgen receptor (AR) has been identified as an important process driving prostate cancer (PCa) progression. Here, the authors analyze the role of AR chromatin binding heterogeneity in PCa clinical outcomes, metastasi
Externí odkaz:
https://doaj.org/article/391fd7851a8744c0932eb78127f219b4
Autor:
Tunç Morova, Daniel R. McNeill, Nada Lallous, Mehmet Gönen, Kush Dalal, David M. Wilson, Attila Gürsoy, Özlem Keskin, Nathan A. Lack
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Androgen receptor (AR) mediated transcription is critical to prostate tumorigenesis and development. Here, utilising clinical whole genome sequencing data, the authors show that the non-coding AR binding sites on DNA are frequently mutated in prostat
Externí odkaz:
https://doaj.org/article/15a98cfbbcff421a8c1487325afd7722
Publikováno v:
Cells, Vol 11, Iss 5, p 898 (2022)
Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other transcri
Externí odkaz:
https://doaj.org/article/78e91ed0949a4d4189c804153aadb961
Autor:
Fatma Özgün, Martin E. van Royen, Adriaan B Houtsmuller, Tsion E Abraham, Nathan A. Lack, Bart Geverts, Zeynep Kaya, Tunç Morova
Publikováno v:
Journal of Cell Science, 134(14):jcs258332. Company of Biologists Ltd
Androgen receptor (AR) splice variants are proposed to be a potential driver of lethal castration-resistant prostate cancer. AR splice variant 7 (ARv7) is the most commonly observed isoform and strongly correlates with resistance to second-generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d538a977b3d5a4df03aec74f1922b9
https://pure.eur.nl/en/publications/69dc424f-d8cf-4a7c-a2c6-396aa466a620
https://pure.eur.nl/en/publications/69dc424f-d8cf-4a7c-a2c6-396aa466a620
Autor:
Nathan A. Lack, Günsay R, Alisan Kayabolen, Ezgi Yagmur Kala, Tunç Morova, Karabiyik G, Tamer T. Onder, Bengul Gokbayrak, Aksu Ac, Yedier-Bayram O, Ayse Derya Cavga, Fırat Uyulur, Tugba Bagci-Onder
Dysregulation of the epigenome due to alterations in chromatin modifier proteins commonly contribute to malignant transformation. To discover new drug targets for more targeted and personalized therapies, functional interrogation of epigenetic modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::870520b9a0b0e2157587f040171ac311
https://doi.org/10.1101/2021.05.14.444239
https://doi.org/10.1101/2021.05.14.444239
Autor:
Tommer Schwarz, Ji Hae Seo, Chia-Chi Flora Huang, Bogdan Pasaniuc, Yi Ding, Wilbert Zwart, David Y. Takeda, Faraz Hach, Mark Pomerantz, Zacharia S, Stefan Groha, Cynthia A Kalita, Mathew Freedman, Singler C, Wang, Tunç Morova, Sylvan C. Baca, Christopher Sweeney, Linder S, Alexander Gusev, Nathan A. Lack
Methods that link genetic variation to steady-state gene expression levels, such as expression quantitative trait loci (eQTLs), are widely used to functionally annotate trait-associated variants, but they are limited in identifying context-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecbc89117dfca02cdc4f1bbd77a4881e
https://doi.org/10.21203/rs.3.rs-514642/v1
https://doi.org/10.21203/rs.3.rs-514642/v1
Autor:
Marlous Hoogstraat, Shreyas Lingadahalli, Faraz Hach, Suzan Stelloo, Nathan A. Lack, Martin E. Gleave, Bengul Gokbayrak, Eldon Emberly, Eugene Hu, Tunç Morova, Mohammadali Saffarzadeh, Ivan Pak Lok Yu, Dogancan Ozturan, Simon Linder, Chia Chi Flora Huang, Funda Sar, Colin Collins, Stephane Le Bihan, Henk G. van der Poel, Andries M. Bergman, Wilbert Zwart, Brian McConeghy, Umut Berkay Altintas, Felix Y. Feng
Androgen receptor (AR) is critical to the initiation, growth and progression of almost all prostate cancers. Once activated, the AR binds to cis-regulatory enhancer elements on DNA that drive gene expression. Yet, there are 10-100x more binding sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddd63495a76106ef8af3f77b361525aa
https://doi.org/10.1101/2020.08.18.255232
https://doi.org/10.1101/2020.08.18.255232
Autor:
Nada Lallous, Attila Gursoy, Ozlem Keskin, Tunç Morova, Daniel R. McNeill, David M. Wilson, Nathan A. Lack, Kush Dalal, Mehmet Gönen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
Androgen receptor (AR) signalling is essential in nearly all prostate cancers. Any alterations to AR-mediated transcription can have a profound effect on carcinogenesis and tumor growth. While mutations of the AR protein have been extensively studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8032152423f257f12e7069ffe33ce05d
http://hdl.handle.net/1942/30774
http://hdl.handle.net/1942/30774
Autor:
Akane Kawamura, Nathan A. Lack, James S. O. McCullagh, Tunç Morova, Tamer T. Onder, Hilal Saraç, Anıl Kaplan, Ahmet Cingoz, Tugba Bagci-Onder, Elisabete Pires
Publikováno v:
Oncogene
Androgen deprivation therapy (ADT) is the standard care for prostate cancer (PCa) patients who fail surgery or radiotherapy. While initially effective, the cancer almost always recurs as a more aggressive castration resistant prostate cancer (CRPC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c087a5741d121d9f36fdc5a3df587a9
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Ezgi Ozyerli-Goknar, Ezgi Yagmur Kala, Ali Cenk Aksu, Ipek Bulut, Ahmet Cingöz, Sheikh Nizamuddin, Martin Biniossek, Fidan Seker-Polat, Tunc Morova, Can Aztekin, Sonia H. Y. Kung, Hamzah Syed, Nurcan Tuncbag, Mehmet Gönen, Martin Philpott, Adam P. Cribbs, Ceyda Acilan, Nathan A. Lack, Tamer T. Onder, H. T. Marc Timmers, Tugba Bagci-Onder
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Glioblastoma is the most common and aggressive primary brain tumor with extremely poor prognosis, highlighting an urgent need for developing novel treatment options. Identifying epigenetic vulnerabilities of cancer cells can provi
Externí odkaz:
https://doaj.org/article/c47591d07edf46c2af096d40cbb069fd