Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Tumour virus infections"'
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
NPJ Genomic Medicine
NPJ Genomic Medicine
Oncogenic human papillomavirus (HPV) genomes are often integrated into host chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single copy, or as tandem repeats of viral DNA interspersed with, or without, host DNA. Integrat
Autor:
Benjamin Freiberg, Netanya S. Utay, Omar A. Saldarriaga, Daniel Millian, Heather L. Stevenson, Bradley Dye, Michael Kueht, Timothy G. Wanninger, Judy Pham
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Direct-acting antivirals (DAA) have replaced interferon (IFN)-based therapies for hepatitis C virus. In this retrospective clinical study, we examined differences in histopathologic features in paired liver biopsies collected from the same patient be
Autor:
Jason Y. K. Chan, Vivian Wai Yan Lui, Sau Dan Lee, Trevor J. Pugh, Brigette B.Y. Ma, Yvonne Y. Y. Or, Kwok Wai Lo, Lee Fah Yap, Yuk-Yu Chan, Edwin P. Hui, Fei-Fei Liu, Yuchen Liu, Michael K. F. Mak, Chit Chow, Pui Kei Siu, Anthony T.C. Chan, Samah El Ghamrasni, Chi Man Tsang, Grace Tin-Yun Chung, Johnny S. H. Kwan, Ian C. Paterson, Jeff Bruce, Man Wu, C. Andrew van Hasselt, Kevin Y. Yip, Christopher W. Dawson, Sai Wah Tsao, John K. S. Woo, Sharmila Velapasamy, Ka Fai To, Lawrence S. Young, Stephenie Prokopec
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Interplay between EBV infection and acquired genetic alterations during nasopharyngeal carcinoma (NPC) development remains vague. Here we report a comprehensive genomic analysis of 70 NPCs, combining whole-genome sequencing (WGS) of microdissected tu
Autor:
Timothy Kottke, Laura Evgin, Christopher B. Driscoll, Phonphimon Wongthida, Jill Thompson, Brady Zell, Adel Samson, Jason M. Tonne, Amanda L. Huff, Lewis R. Roberts, Elizabeth Ilett, Peter Selby, Alan Melcher, Kevin J. Harrington, Jacob van Vloten, Mitesh J. Borad, Hardev Pandha, Matthew Schuelke, Richard G. Vile, Mark A. McNiven, Victoria A. Jennings, Jose S. Pulido
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
In our clinical trials of oncolytic vesicular stomatitis virus expressing interferon beta (VSV-IFNβ), several patients achieved initial responses followed by aggressive relapse. We show here that VSV-IFNβ-escape tumors predictably express a point-m
Autor:
Roman Groisberg, Gilberto Morgan, Balazs Halmos, Pashtoon Murtaza Kasi, Haeseong Park, Justin F. Gainor, Sumanta K. Pal, Enrique Grande, Naveen Pemmaraju, Shumei Kato, Aakash Desai, Sant P. Chawla, Aparna Hegde, Alison M. Schram, Toni K. Choueiri, Tomislav Dragovich, Benjamin Solomon, Giuseppe Curigliano, Stephen V. Liu, Herbert H. Loong, Neeraj Agarwal, Marc R. Matrana, Ishwaria Mohan Subbiah, Vivek Subbiah
Publikováno v:
Nature Reviews. Clinical Oncology
Emerging efficacy data have led to the emergency use authorization or approval of COVID-19 vaccines in several countries worldwide. Most trials of COVID-19 vaccines excluded patients with active malignancies, and thus data on the safety, tolerability
Autor:
Benedict Panizza, Michelle A Neller, Pauline Crooks, Sandro V. Porceddu, Laetitia Le Texier, Katherine K. Matthews, Corey Smith, Margaret McGrath, Rajiv Khanna
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-5 (2021)
NPJ Precision Oncology
NPJ Precision Oncology
Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated heterogeneous disease and is characterized by peritumoral immune infiltrate. Adoptive T-cell therapy (ACT) has emerged as a potential therapeutic strategy for NPC. However, th
Autor:
Julien Puech, Marie-Laure Lucas, Simon Pernot, Raphael Vernet, David Veyer, Laurence Weiss, Cécile Badoual, Bastien Rance, Nicolas Robillard, Hélène Péré, Laurent Bélec, Sonia Lameiras, Alain Nicolas, Maxime Wack, Juliette Pavie
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
Scientific Reports
Scientific Reports, 2021, 11 (1), pp.4633. ⟨10.1038/s41598-021-84110-2⟩
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.4633. ⟨10.1038/s41598-021-84110-2⟩
Scientific Reports
Scientific Reports, 2021, 11 (1), pp.4633. ⟨10.1038/s41598-021-84110-2⟩
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.4633. ⟨10.1038/s41598-021-84110-2⟩
Archival tissue samples collected longitudinally from a patient who died from HPV16-induced high-grade anal intraepithelial squamous cell carcinoma with vertebral HPV16–positive metastasis were retrospectively analyzed by the Capture-HPV method (Ca
Autor:
Masako Iwanaga, Atae Utsunomiya, Seiichiro Kobayashi, Kazumi Nakano, Kaoru Uchimaru, Yohei Chihara, Toshiki Watanabe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Wnt5a is a ligand of the non-canonical Wnt signaling pathway involved in cell differentiation, motility, and inflammatory response. Adult T-cell leukemia/lymphoma (ATL) is one of the most aggressive T-cell malignancies caused by infection of human T-
Autor:
Brian M. Alexander, Kevin Jon Williams, Jacob R. Bledsoe, Meagan Montesion, Erik A. Williams, Julie Y. Tse, Mark C. Mochel, Krzysztof Glomski, Jeffrey S. Ross, Julia A. Elvin, Shakti H. Ramkissoon
Publikováno v:
Modern Pathology
Mutations in the tumor suppressor CYLD, known to be causative of cylindromas, were recently described in a subset of high-risk (hr) HPV-positive head and neck squamous cell carcinomas (HNSCC). Pathologic and genetic characterization of these CYLD-mut
Autor:
Nagaki Ohnuki, Masatoshi Hori, Yasushi Torii, Kazuhiko Imakawa, Tomoko Kobayashi, Kazuya Kusama, Yorifumi Satou, Yasuko Inagaki, Misaki Matsuo, Kohei Nishikaku
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Bovine leukemia virus (BLV) is an oncogenic retrovirus which induces malignant lymphoma termed enzootic bovine leukosis (EBL) after a long incubation period. Insertion sites of the BLV proviral genome as well as the associations between disease progr