Zobrazeno 1 - 10
of 581
pro vyhledávání: '"Tumour suppressor genes"'
Autor:
Yuka Takemon, Erin D. Pleasance, Alessia Gagliardi, Christopher S. Hughes, Veronika Csizmok, Kathleen Wee, Diane L. Trinh, Ryan D. Huff, Andrew J. Mungall, Richard A. Moore, Eric Chuah, Karen L. Mungall, Eleanor Lewis, Jessica Nelson, Howard J. Lim, Daniel J. Renouf, Steven JM. Jones, Janessa Laskin, Marco A. Marra
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-31 (2024)
Abstract Background Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted. Approaches characterising gene function and vulnerabilities conferred by such mutations are required. Methods Here, we computationally map
Externí odkaz:
https://doaj.org/article/2954f6a10f424393a3fd559481966131
Autor:
Nadja Nikolic, Jelena Carkic, Jelena Jacimovic, Aleksandar Jakovljevic, Boban Anicic, Zoran Jezdic, Jelena Milasin
Publikováno v:
Epigenetics, Vol 17, Iss 12, Pp 1661-1676 (2022)
The aim of the present systematic review was to critically analyse the relationship between tumour suppressor genes (TSGs) promoter methylation, a potent mechanism of gene silencing, and the development of salivary gland tumours, as well as the possi
Externí odkaz:
https://doaj.org/article/d44f243442bb4693bb69881dabf25bb7
Akademický článek
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Autor:
Mohammed Adel Awawdeh, Rekha Sasikumar, Ali Anwar Aboalela, Salman Siddeeqh, Pillai Arun Gopinathan, Faleh Sawair, Sanjeev B. Khanagar
Publikováno v:
Applied Sciences, Vol 13, Iss 9, p 5292 (2023)
The majority of all head and neck tumours are squamous cell carcinomas (SCC). Recent advancements have assisted in producing a body of evidence for the genetic origins of these tumours. Identifying prognostic biomarkers in oral SCC would be of great
Externí odkaz:
https://doaj.org/article/0e3d3219086a409d8634982d790af4d7
Autor:
Md Shamshir Alam, Garima Malik, Priyanka Tanwar, Mamta Naagar, Tarun Singh, Omveer Singh, Manish Kumar Maity
Small-cell lung cancer (SCLC) accounts for roughly 15% of all lung malignancies and is distinguished by a high proliferative rate, a proclivity for early metastasis, and a poor prognosis. Exposure to cigarette carcinogens is highly linked to SCLC. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fbd30fae83a46ea20026240f5acc5e
Akademický článek
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Autor:
Maria Wielsøe, Valentina Bollati, Manhai Long, Eva Cecilie Bonefeld-Jørgensen, Letizia Tarantini
Publikováno v:
Wielsøe, M, Tarantini, L, Bollati, V, Long, M & Bonefeld-Jørgensen, E C 2020, ' DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women ', Basic & Clinical Pharmacology & Toxicology, vol. 127, no. 4, pp. 338-350 . https://doi.org/10.1111/bcpt.13424
Basic & Clinical Pharmacology & Toxicology
Basic & Clinical Pharmacology & Toxicology
Several studies have found aberrant DNA methylation levels in breast cancer cases, but factors influencing DNA methylation patterns and the mechanisms are not well understood. This case–control study evaluated blood methylation level of two repetit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8aea9e7c4fe93f3be400a7f22c1b6b
https://doi.org/10.1111/bcpt.13424
https://doi.org/10.1111/bcpt.13424
Autor:
Eleonora Zorzan, Ramy Elgendy, Giorgia Guerra, Silvia Da Ros, Maria Elena Gelain, Federico Bonsembiante, Giulia Garaffo, Nicoletta Vitale, Roberto Piva, Laura Marconato, Luca Aresu, Mauro Dacasto, Mery Giantin
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 4021
Gene expression is controlled by epigenetic deregulation, a hallmark of cancer. The DNA methylome of canine diffuse large B-cell lymphoma (cDLBCL), the most frequent malignancy of B-lymphocytes in dog, has recently been investigated, suggesting that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93df527b338bb61e7a42b7666e61e636
http://hdl.handle.net/11585/882875
http://hdl.handle.net/11585/882875
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11701, p 11701 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Lung cancer is the leading cause of cancer mortality in both genders, with non-small cell lung cancer (NSCLC) accounting for about 85% of all lung cancers. At the time of diagnosis, the tumour is usually locally advanced or metastatic, shaping a poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e73c7844bee243a2cfa1cc0c5acac6
https://pubmed.ncbi.nlm.nih.gov/34769131
https://pubmed.ncbi.nlm.nih.gov/34769131