Výsledky vyhledávání - "Tumour necrosis factor receptor-associated factor 6"

Akademický článek

Asiaticoside reverses M2 phenotype macrophage polarization-evoked osteosarcoma cell malignant behaviour by TRAF6/NF-κB inhibition

Autor: Dang-ke Li, Guang-hui Wang

Publikováno v: Pharmaceutical Biology, Vol 60, Iss 1, Pp 1635-1645 (2022)

Context M2 phenotype macrophage polarization is an attractive target for therapeutic intervention. Asiaticoside (ATS) has multiple pharmacological functions.Objective This study investigates the effect of ATS on M2 phenotype macrophage polarization i

Externí odkaz: https://doaj.org/article/fcc6a7d43ca244c3ad04ecf9dd7f4d69

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Akademický článek

Increasd mRNA expression of TRAF-6 and MST-4 in the placenta of women with preterm premature rupture of membranes with histological chorioamnionitis

Autor: D. Lu, X. Bao, Q. Wang

Publikováno v: Clinical and Experimental Obstetrics & Gynecology, Vol 47, Iss 5, Pp 749-754 (2020)

Objectives: To investigate the expression of mammalian Ste20-like kinase 4 (MST-4) and tumour necrosis factor receptor-associated factor 6 (TRAF-6) in placenta from cases with preterm premature rupture of membranes (PPROM) with histological chorioamn

Externí odkaz: https://doaj.org/article/b2e9e923b69246acb2eb9bcc9ef8e7e8

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Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic

Autor: Damanpreet Singh, Anil Kumar Rana, Shubham Nilkanth Rahmatkar, Amit Kumar

Publikováno v: Cytokine & Growth Factor Reviews

Graphical abstract
Highlights • Systemic oxidative stress and inflammation are significant outcomes of SARS-CoV-2 infection. • Activated Gsk-3 following SARS-CoV-2 infection provoke the oxidative stress and inflammation in the host. • Gsk-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2341a436aa2d7b5cd262c39784c0248d
https://pubmed.ncbi.nlm.nih.gov/32948440

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Akademický článek

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APPL proteins promote TGF beta-induced nuclear transport of the TGF beta type I receptor intracellular domain

Autor: Maréne Landström, Yabing Mu, Carl-Henrik Heldin, Chunyan Li, Marta Miaczynska, Anders Bergh, Jie Song

Publikováno v: Oncotarget

The multifunctional cytokine transforming growth factor-beta (TGF beta) is produced by several types of cancers, including prostate cancer, and promote tumour progression in autocrine and paracrine manners. In response to ligand binding, the TGF beta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095d7a65291ea0327515e3f2f6787f20
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280903

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Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

Autor: Harald W. Platta, Hilde Abrahamsen, Harald Stenmark, Sigrid B. Thoresen

Publikováno v: Biochemical Journal

Beclin 1, a subunit of the class III phosphatidylinositol 3-kinase complex, is a tumour suppressor with a central role in endocytic trafficking, cytokinesis and the cross-regulation between autophagy and apoptosis. Interestingly, not only reduced exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806579558afbfb335b2204b9e8386448
https://doi.org/10.1042/bj20111424

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How ubiquitination and autophagy participate in the regulation of the cell response to bacterial infection

Autor: Nassima Temime-Smaali, Frank Lafont, Nicolas Dupont

Publikováno v: Biology of the Cell

Bacterial infection relies on the micro-organism's ability to orchestrate the host's cell signalling such that the immune response is not activated. Conversely, the host cell has dedicated signalling pathways for coping with intrusions by pathogens.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144f44d392d36d678cc3f7513d1f46ea
https://doi.org/10.1042/bc20100101

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

Autor: Helen Walden, Donald E. Spratt, Gary S. Shaw

Publikováno v: Biochemical Journal

The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes. This unique family of E3 ligases includes parkin, whose dysfunction is linked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cedff32799050efc0f1ef4664dad485
https://pubmed.ncbi.nlm.nih.gov/24576094

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