Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Tumor-initiating cell"'
Autor:
Jingtao Liu, Ming Tao, Wei Zhao, Qingru Song, Xiaodan Yang, Meng Li, Yanhua Zhang, Dianrong Xiu, Zhiqian Zhang
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 2, Pp 373-392 (2023)
Background & Aims: Tumor-initiating cells (TICs) drive pancreatic cancer tumorigenesis, therapeutic resistance, and metastasis. However, TICs are highly plastic and heterogenous, which impede the robust identification and targeted therapy of such a p
Externí odkaz:
https://doaj.org/article/28206f1baad94f5bb1f8a00f2af44bd3
Autor:
Chad Nakagawa, Manjunatha Kadlera Nagaraj, Juan Carlos Hernandez, Dinesh Babu Uthay Kumar, Vivek Shukla, Risa Machida, Jörg Schüttrumpf, Linda Sher, Patrizia Farci, Lopa Mishra, Stanley M. Tahara, Jing-Hsiung James Ou, Keigo Machida
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTumor-initiating cells (TICs) are rare, stem-like, and highly malignant. Although intravenous hepatitis B and C immunoglobulins have been used for HBV and HCV neutralization in patients, their tumor-inhibitory effects have not yet been ex
Externí odkaz:
https://doaj.org/article/c8d34736f6a64b2da84b7839e34d25e1
Autor:
Lei Li, Rui Zhu, Honghong Zhou, Chun‐Ping Cui, Xiao Yu, Yuhao Liu, Yin Yin, Yang Li, Riyue Feng, Jonathan P. Katz, Yahui Zhao, Yun Zhang, Lingqiang Zhang, Zhihua Liu
Publikováno v:
Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)
Abstract β‐TrCP is an E3 ubiquitin ligase that plays important roles in multiple human cancers including esophageal squamous cell carcinoma (ESCC). Analysis of ESCC patient samples reveal that only protein level but not transcript level of β‐Tr
Externí odkaz:
https://doaj.org/article/b242253180974424bb1c215e632f7a0b
Publikováno v:
Journal of Hepatocellular Carcinoma, Vol Volume 8, Pp 1537-1563 (2021)
Jiliang Feng,1 Ruidong Zhu,2 Yu Yin,3 Shanshan Wang,1 Lei Zhou,4 Fudong Lv,1 Dawei Zhao5 1Clinical-Pathology Center, Beijing You-An Hospital, Capital Medical University, Beijing, 100069, People’s Republic of China; 2General Surgical Center, Beijing
Externí odkaz:
https://doaj.org/article/e3fe616b48734044a15c335898fb93c5
Autor:
Dingqing Feng, Keqin Yan, Haiyan Liang, Jing Liang, Wenhui Wang, Huan Yu, Ying Zhou, Weidong Zhao, Zhongjun Dong, Bin Ling
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 1-11 (2021)
Our previous work demonstrated that Piwil2 reactivated by the human papillomavirus oncoproteins E6 and E7 may reprogram somatic cells into tumor-initiating cells (TICs), which contribute to cervical neoplasia lesions. Maintaining the stemness of TICs
Externí odkaz:
https://doaj.org/article/4e0581fbfee34af39ca8d2460aa17836
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-28 (2021)
Abstract Background Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number of studies reveal that cancer cells share the property and regulatory network with neural stem/progenitor cells. However, relationship bet
Externí odkaz:
https://doaj.org/article/bf96e563befd45a0a3c949aa124fc136
Autor:
Zeyu Wang, Shasha Zhao, Xiaolin Lin, Guanglong Chen, Jiawei Kang, Zhongping Ma, Yiming Wang, Zhi Li, Xiuying Xiao, Aina He, Dongxi Xiang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Organoids well recapitulate organ-specific functions from their tissue of origin and remain fundamental aspects of organogenesis. Organoids are widely applied in biomedical research, drug discovery, and regenerative medicine. There are various cultiv
Externí odkaz:
https://doaj.org/article/098afefdb49949e89bf2cd3b115cabe0
Publikováno v:
Redox Biology, Vol 44, Iss , Pp 101953- (2021)
Controlling reactive oxygen species (ROS) at sustainable levels can drive multiple facets of tumor biology, including within the cancer stem cell (CSC) population. Tight regulation of ROS is one key component in CSCs that drives disease recurrence, c
Externí odkaz:
https://doaj.org/article/a2e4b062b5a746059e639a3ae34e831a
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effect
Externí odkaz:
https://doaj.org/article/9abd25ef9a0545b4af3e3908c09df06e
Autor:
Kiera Walker, Nathaniel H. Boyd, Joshua C. Anderson, Christopher D. Willey, Anita B. Hjelmeland
Publikováno v:
Biomarker Research, Vol 6, Iss 1, Pp 1-9 (2018)
Abstract Background For glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model physiologic levels, nor
Externí odkaz:
https://doaj.org/article/57c3f77f24544eada62c4a8c6e83e0d3