Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Tumor-infiltrating leukocytes"'
Autor:
Anna Sandström Gerdtsson, Mattis Knulst, Johan Botling, Artur Mezheyeuski, Patrick Micke, Sara Ek
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe immune microenvironment of non-small cell lung cancer (NSCLC) is heterogeneous, which impedes the prediction of response to immune checkpoint inhibitors. We have mapped the expression of 49 proteins to spatial immune niches in 33 NSCLC tu
Externí odkaz:
https://doaj.org/article/741394138eef44ecae9ba7ccc63aed84
Autor:
Malte Simon, Sadaf S. Mughal, Peter Horak, Sebastian Uhrig, Jonas Buchloh, Bogac Aybey, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Benedikt Brors, Charles D. Imbusch
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Soft-tissue sarcomas (STS) are a heterogeneous group of mesenchymal tumors for which response to immunotherapies is not well established. Therefore, it is important to risk-stratify and identify STS patients who will most likely b
Externí odkaz:
https://doaj.org/article/95d5e3905f64467eb28b20271478949f
Autor:
Federica Laudisi, Fabio Cherubini, Antonio Di Grazia, Vincenzo Dinallo, Davide Di Fusco, Eleonora Franzè, Angela Ortenzi, Illari Salvatori, Silvia Scaricamazza, Ivan Monteleone, Naoya Sakamoto, Giovanni Monteleone, Carmine Stolfi
Publikováno v:
Molecular Oncology, Vol 13, Iss 10, Pp 2142-2159 (2019)
Persistent activation of Signal Transducer and Activator of Transcription (STAT)3 occurs in a high percentage of tumors, including colorectal cancer (CRC), thereby contributing to malignant cell proliferation and survival. Although STAT3 is recognize
Externí odkaz:
https://doaj.org/article/124e3a886d294b1987dbedcafaddeff2
Publikováno v:
Cancer Communications, Vol 39, Iss 1, Pp 1-9 (2019)
Abstract Tumor immune microenvironment is closely related to tumor initiation, prognosis, and response to immunotherapy. The immune landscapes, number of infiltrating immune cells, and the localization of lymphocytes in the tumor vary in across diffe
Externí odkaz:
https://doaj.org/article/61cde951c2ce4b42af36fdccf563653d
Autor:
Rispah T. Sawe, Simeon K. Mining, Ayub V. Ofulla, Kirtika Patel, Bernard Guyah, David Chumba, Jenifer R. Prosperi, Maggie Kerper, Zonggao Shi, Mayra Sandoval-Cooper, Katherine Taylor, Sunil Badve, M. Sharon Stack, Laurie E. Littlepage
Publikováno v:
Tropical Medicine and Health, Vol 45, Iss 1, Pp 1-11 (2017)
Abstract Background Tumors commonly are infiltrated by leukocytes, or tumor infiltrating leukocytes (TILs). It remains unclear, however, if the density and type of individual TILs has a direct or simply correlative role in promoting poor prognosis in
Externí odkaz:
https://doaj.org/article/bc9d8036117e4138875f80d15ede4d65
Autor:
Fazrena Nadia Md Akhir, Mohd Hezmee Mohd Noor, Keith Weng Kit Leong, Jamileh A. Nabizadeh, Helga D. Manthey, Stefan E. Sonderegger, Jenny Nga Ting Fung, Crystal E. McGirr, Ian A. Shiels, Paul C. Mills, Trent M. Woodruff, Barbara E. Rolfe
Publikováno v:
Antibodies, Vol 10, Iss 1, p 2 (2021)
The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptor
Externí odkaz:
https://doaj.org/article/ed5826c8ab7746d6bb9209f09dfcb2ce
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 602 (2020)
Background: Inflammation is known to promote tumor formation and progression; however, we found a natural anti-inflammatory factor, interleukin (IL)-1 receptor antagonist (IL1RN), in a mouse transgenic adenocarcinoma of the mouse prostate (TRAMP)-C1-
Externí odkaz:
https://doaj.org/article/c509c13e504b46749abd9b3ea1e6e59a
Publikováno v:
Biology, Vol 9, Iss 4, p 67 (2020)
Background: Several lines of evidence have demonstrated the tumor-promoting function of inflammation. Since many chemokines are important in coordinating immune cells during inflammation, monitoring intratumoral chemokines provides a way to study the
Externí odkaz:
https://doaj.org/article/ba039845f2574e3a8d4d9eeaf8677517
Autor:
Suneesh Kaimala, Ashraf Al-Sbiei, Otavio Cabral-Marques, Maria J. Fernandez-Cabezudo, Basel K. Al-Ramadi
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
The use of attenuated bacteria as cancer therapeutic tools has garnered increasing scientific interest over the past 10 years. This is largely due to the development of bacterial strains that maintain good anti-tumor efficacy, but with reduced potent
Externí odkaz:
https://doaj.org/article/c739b3f39a4f4849b61afe79d99c0196
Autor:
Hisayuki Tono, Taku Fujimura, Eimei Iwama, Yoshiyuki Kusakari, Sadanori Furudate, Yumi Kambayashi, Takahiro Haga, Akira Hashimoto, Setsuya Aiba
Publikováno v:
Case Reports in Dermatology, Vol 7, Iss 1, Pp 1-6 (2015)
Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrati
Externí odkaz:
https://doaj.org/article/edd2d9b0a9a6428a859171e3f1a17a68