Zobrazeno 1 - 10
of 2 249
pro vyhledávání: '"Tumor xenograft"'
Autor:
Masanori Ozaki, Ken Kageyama, Kenjiro Kimura, Shinpei Eguchi, Akira Yamamoto, Ryota Tanaka, Takehito Nota, Hiroki Yonezawa, Hideyuki Nishiofuku, Yuki Sakai, Naoki Tani, Atsushi Jogo, Mizue Terai, Takami Sato, Takeaki Ishizawa, Yukio Miki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Liver metastases from pancreatic ductal adenocarcinoma (PDAC) are highly fatal. A rat-based patient-derived tumor xenograft (PDX) model is available for transcatheter therapy. This study aimed to create an immunodeficient rat model with live
Externí odkaz:
https://doaj.org/article/a062ad6132a74f5f94005ead20d308ed
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 4, Pp 435-443 (2024)
Objective·To establish a patient-derived tumor xenograft (PDX) model using tumor cells sourced from malignant pleural effusion (MPE) in patients with lung cancer, and to conduct experimental validation.Methods·Gene expression data were downloaded f
Externí odkaz:
https://doaj.org/article/3154cd54e811497ab87555d4cf9ea723
Autor:
Xiaojie Chu, Seungmin Shin, Du-San Baek, Liyong Zhang, Alex Conard, Megan Shi, Ye-Jin Kim, Cynthia Adams, Maggie Hines, Xianglei Liu, Chuan Chen, Zehua Sun, Dontcho V. Jelev, John W. Mellors, Dimiter S. Dimitrov, Wei Li
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Prostate stem cell antigen (PSCA) is expressed in all stages of prostate cancer, including in advanced androgen-independent tumors and bone metastasis. PSCA may associate with prostate carcinogenesis and lineage plasticity in prostate cancer. PSCA is
Externí odkaz:
https://doaj.org/article/1f085d6811ce4dcda8bde14f50a5302f
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 2, Pp 69-75 (2023)
Objective: AST-3424 is a novel specific aldo-keto reductase 1C3 (AKR1C3) prodrug that releases a DNA alkylating reagent upon reduction by AKR1C3. This study aimed to evaluate the efficacy and safety of AST-3424 in patient-derived tumor xenograft (PDT
Externí odkaz:
https://doaj.org/article/4be4ad79cff343dc8b0d7602b9af2104
Autor:
Yixiao Bin, Sanhua Wei, Ruo Chen, Haowei Zhang, Jing Ren, Peijuan Liu, Zhiqian Xin, Tianjiao Zhang, Haijiao Yang, Ke Wang, Zhuan Feng, Xiuxuan Sun, Zhinan Chen, Hai Zhang
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 180 (2024)
Severe combined immunodeficient (SCID) mice serve as a critical model for human xenotransplantation studies, yet they often suffer from low engraftment rates and susceptibility to graft-versus-host disease (GVHD). Moreover, certain SCID strains demon
Externí odkaz:
https://doaj.org/article/e7faabe2416a4baf92bcef238975f733
Autor:
Marshall D. Behrens, Robert J. Stiles, Gennett M. Pike, Laura A. Sikkink, Yongxian Zhuang, Jia Yu, Liewei Wang, Judy C. Boughey, Matthew P. Goetz, Mark J. Federspiel
Publikováno v:
Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 239-255 (2022)
Historically, the clinical utility of oncolytic virotherapy as a treatment for a wide range of cancer types was first demonstrated by three pilot human clinical trials conducted in Japan in the 1970s and 1980s using a wild-type Urabe mumps virus (MuV
Externí odkaz:
https://doaj.org/article/b9ed91b0cb974385bc37be3b4a346fb0
Autor:
Yong-Hee Cho
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 11, Pp 5352-5362 (2022)
Intensive efforts to develop anti-cancer agents have been made for over 60 years. However, cancer is still considered a lethal disease. To study the best anti-cancer agents for improving the survival rates of cancer patients, many researchers have fo
Externí odkaz:
https://doaj.org/article/255f40c8c5f74fb5b5745a0251141480
Autor:
Tomoko Tachibana, Tomoko Gowa Oyama, Yukie Yoshii, Fukiko Hihara, Chika Igarashi, Mitsuhiro Shinada, Hiroki Matsumoto, Tatsuya Higashi, Toshihiko Kishimoto, Mitsumasa Taguchi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17234 (2023)
Managing metastasis at the early stage and detecting and treating submillimeter tumors at early metastasis are crucial for improving cancer prognosis. Angiogenesis is a critical target for developing drugs to detect and inhibit submillimeter tumor gr
Externí odkaz:
https://doaj.org/article/11c3e5dfcac2430f9f99d0cd36bfbfbb
Akademický článek
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Autor:
Cheng-Chih Hsieh, Cheng-Yu Yang, Bo Peng, Sien-Lin Ho, Chang-Huei Tsao, Chih-Kung Lin, Chun-Shu Lin, Gu-Jiun Lin, Heng-Yi Lin, Hung-Chi Huang, Szu-Chien Chang, Huey-Kang Sytwu, Wei-Tso Chia, Yuan-Wu Chen
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2669 (2023)
The dysregulated expression of cyclin genes can lead to the uncontrolled proliferation of cancer cells. Histone demethylase Jumonji-C domain-containing protein 5 (KDM8, JMJD5) and cyclin A1 (CCNA1) are pivotal in cell cycle progression. A promising c
Externí odkaz:
https://doaj.org/article/8d06481f16474b74a3a093c0abf5af77