Zobrazeno 1 - 10
of 5 139
pro vyhledávání: '"Tumor suppression"'
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/b45ffca8a5bc452db20b9a1b7d042e7b
Autor:
Jian Huang, Ting Zhang, Julia Kalashova, Jinhua Li, Chenglu Yang, Linsheng Zhong, Xiaohu Zhou, Qiong Shi, Gang Lv, Jiadai Chenyu, Yidan Xia Abuliezi, Duo Yu, Xuejiao Jiang, Mallu Chenna Reddy, Namrta Choudhry, Naganna Nimishetti, Dun Yang
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 11, Iss , Pp 100145- (2024)
Mitotic kinesin-like protein 2 (MKLP2/KIF20A) is a key mitotic regulator frequently overexpressed in human malignancies and its abundance is positively correlated with poor outcomes of the disease. Despite extensive research on MKLP2 as a potential t
Externí odkaz:
https://doaj.org/article/a027eb80fad1449fb931fbcbb6238dde
Publikováno v:
Advanced Science, Vol 11, Iss 25, Pp n/a-n/a (2024)
Abstract The generally undesirable bandgap and electron–hole complexation of inorganic sonosensitizers limit the efficiency of reactive oxygen species (ROS) generation, affecting the effectiveness of sonodynamic therapy (SDT). Comparatively, the no
Externí odkaz:
https://doaj.org/article/f4b721eecdbb47968de9080dbf978aec
Publikováno v:
Zhongguo linchuang yanjiu, Vol 37, Iss 1, Pp 6-11 (2024)
Mast cells are a type of innate immune cells, and have long been considered to be related to the pathogenesis of allergic and autoimmune diseases. However, in recent years, a number of studies have found that mast cells play an indispensable role in
Externí odkaz:
https://doaj.org/article/0835272fb9a84a5f81d1ad3e1d5afd59
Publikováno v:
Heliyon, Vol 10, Iss 6, Pp e27731- (2024)
Malignant mesothelioma (MM) is a very aggressive neoplasia with a short life expectancy and limited therapeutic options. Thus, the identification of novel molecular targets is a matter of great urgency. Kelch-like (KLHL) proteins play an important ro
Externí odkaz:
https://doaj.org/article/54dfef4338fc4a10a704c668957d597a
Publikováno v:
Cells, Vol 13, Iss 16, p 1356 (2024)
Given the importance of peroxisome proliferator-activated receptor (PPAR)-gamma in epidermal inflammation and carcinogenesis, we analyzed the transcriptomic changes observed in epidermal PPARγ-deficient mice (Pparg-/-epi). A gene set enrichment anal
Externí odkaz:
https://doaj.org/article/3b1fef54a9104a02a062633c3534fdde
Autor:
Julien Boudreault, Lucie Canaff, Mostafa Ghozlan, Ni Wang, Vito Guarnieri, Antonio Stefano Salcuni, Alfredo Scillitani, David Goltzman, Suhad Ali, Jean-Jacques Lebrun
Publikováno v:
Cells, Vol 13, Iss 11, p 973 (2024)
Over the past few decades, the worldwide incidence of cutaneous melanoma, a malignant neoplasm arising from melanocytes, has been increasing markedly, leading to the highest rate of skin cancer-related deaths. While localized tumors are easily remove
Externí odkaz:
https://doaj.org/article/d32cec2e3b9644e59590ef5b2ab34a91
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116041- (2024)
The two major challenges in cancer treatment are reducing the side effects and minimizing the cost of cancer treatment. A better therapy to treat cancer remains to be developed despite the presence of many therapeutic options. Here, we present bacter
Externí odkaz:
https://doaj.org/article/dfc33ffcf207459f89f048db331a3e69
Autor:
Zhiying Shao, Wendong Yang, Xiannan Meng, Minle Li, Pingfu Hou, Zhongwei Li, Sufang Chu, Junnian Zheng, Jin Bai
Publikováno v:
Cancer Medicine, Vol 12, Iss 10, Pp 11177-11190 (2023)
Abstract Background Yin Yang‐1 (YY1) is identified as a transcription factor with multiple functions. However, the role of YY1 in tumorigenesis remains controversial and its regulatory effects may depend upon not only cancer types, but also its int
Externí odkaz:
https://doaj.org/article/48fc82e5a16f4b6a8867f4845fb2f7e2
Autor:
Yelena Kravtsova-Ivantsiv, Gilad Goldhirsh, Ciprian Tomuleasa, Eli Pikarsky, Aaron Ciechanover
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Nuclear factor-ĸB (NF-ĸB) is an important transcriptional regulator of key cellular processes, including cell cycle, immune response, and malignant transformation. We found that the ubiquitin ligase Kip1 ubiquitination-promoting complex su
Externí odkaz:
https://doaj.org/article/918e4432e5634576bba28c5195a42d9f