Zobrazeno 1 - 10
of 378
pro vyhledávání: '"Tumor relapse"'
Autor:
Florencia Cascardo, Micaela Vivanco, María Cecilia Perrone, Andrea Werbach, Diego Enrico, Pablo Mando, Mora Amat, Paula Martínez-Vazquez, Javier Burruchaga, María Mac Donnell, Claudia Lanari, Ariel Zwenger, Federico Waisberg, Virginia Novaro
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract PI3K/AKT/mTOR pathway is implicated in breast cancer progression and recurrence. The identification of PIK3CA and AKT1 mutations and loss of PTEN serve as selection criterion for targeted therapies involving selective inhibitors. However, th
Externí odkaz:
https://doaj.org/article/ce09fb118a3c42c3a6eb1d50c923afd6
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117252- (2024)
Chimeric antigen receptor T (CAR-T) cell therapy has shown promise in treating hematological malignancies and certain solid tumors. However, its efficacy is often hindered by negative relapses resulting from antigen escape. This review firstly elucid
Externí odkaz:
https://doaj.org/article/e6aac8a986044436b02bc0a3bc5e70c0
Autor:
Dmitry V. Sverchinsky, Bashar A. Alhasan, Marina A. Mikeladze, Vladimir F. Lazarev, Liubov S. Kuznetcova, Alisa V. Morshneva, Alina D. Nikotina, Amr Ziewanah, Lidia V. Koludarova, Tatiana Y. Starkova, Boris A. Margulis, Irina V. Guzhova
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)
Abstract Background Cancer recurrence is regulated by a variety of factors, among which is the material of dying tumor cells; it is suggested that remaining after anti-cancer therapy tumor cells receive a signal from proteins called damage-associated
Externí odkaz:
https://doaj.org/article/3ad6558362834740b4a23a796ea296c8
Autor:
Sourio Chakraborty, Sumon Mukherjee, Udit Basak, Subhadip Pati, Apratim Dutta, Saikat Dutta, Subhanki Dhar, Tania Sarkar, Aharna Guin, Gaurisankar Sa, Tanya Das
Publikováno v:
Exploration of Immunology, Vol 3, Iss 4, Pp 384-405 (2023)
Cancer stem cells (CSCs) are a small subpopulation of cells that drive the formation and progression of tumors. However, during tumor initiation, how CSCs communicate with neighbouring immune cells to overcome the powerful immune surveillance barrier
Externí odkaz:
https://doaj.org/article/777ed888517245ccac0079cece460259
Publikováno v:
Bioactive Materials, Vol 25, Iss , Pp 689-700 (2023)
The low objective response rates and severe side effects largely limit the clinical outcomes of immune checkpoint blockade (ICB) therapy. Here, a tumor “self-killing” therapy based on gene-guided OX40L anchoring to tumor cell membrane was reporte
Externí odkaz:
https://doaj.org/article/d7e24fd3b4e2431ab75ce8a0fa3cc534
Autor:
Moisés Armides Franco Molina, David Reding Hernández, Paola Leonor García Coronado, Jorge R. Kawas, Diana G. Zárate Triviño, Sara Paola Hernández Martínez, Beatriz Elena Castro Valenzuela, Cristina Rodríguez Padilla
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Introduction: Neoadjuvant therapy constitutes a valuable modality for diminishing tumor volume prior to surgical resection. Nonetheless, its application encounters limitations in the context of recurrent tumors, which manifest resistance to conventio
Externí odkaz:
https://doaj.org/article/5078f479d04d4e95adc72ef45eb33956
Autor:
Jiajia Zhang, Feize Li, Yuzhen Yin, Ning Liu, Mengqin Zhu, Han Zhang, Weihao Liu, Mengdie Yang, Shanshan Qin, Xin Fan, Yuanyou Yang, Kun Zhang, Fei Yu
Publikováno v:
Biomaterials Research, Vol 26, Iss 1, Pp 1-15 (2022)
Abstract Background Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis and
Externí odkaz:
https://doaj.org/article/e777ff6e4de04da79671b3d3e4f92739
Autor:
Kousalya Lavudi, Shreya Madhav Nuguri, Zianne Olverson, Anantha Krishna Dhanabalan, Srinivas Patnaik, Rekha Rani Kokkanti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Retinoic acid (RA) is a vital metabolite derived from vitamin A. RA plays a prominent role during development, which helps in embryological advancement and cellular differentiation. Mechanistically, RA binds to its definite nuclear receptors includin
Externí odkaz:
https://doaj.org/article/506f5e6570bc4afba84bf7fe6a1a527b
Autor:
Gang Deng, Jun-kai Ren, Hai-tao Wang, Liang Deng, Zu-bing Chen, You-wen Fan, Ya-jun Tang, Tong Zhang, Di Tang
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
BackgroundThe prognostic value of the tumor burden score (TBS) in patients with combined hepatocellular-cholangiocarcinoma (cHCC-CCA) remains unknown. This study aimed to investigate the impact of TBS on long-term outcomes after surgery.MethodsPatien
Externí odkaz:
https://doaj.org/article/78c6c4a47ac948609311afd8e33684b2
Autor:
Linah A. Shahoumi
Publikováno v:
Clinical and Translational Discovery, Vol 2, Iss 4, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/907e2701be8a4e1aa06a6a00491ee058