Zobrazeno 1 - 10
of 1 511
pro vyhledávání: '"Tumor penetration"'
Autor:
Wei Lu, Yang Li, Xiaojun Zhang, Ning Wang, Dong Chen, Yatong Zhao, Guang Li, Xuzhi Shi, Xiaobo Ma, Xiaodan Su, Feng Wang, Chuqiang Shu, Kun Chen
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Amidst the burgeoning field of cancer nanomedicine, dense extracellular matrices and anomalous vascular structures in the tumor microenvironment (TME) present substantial physical barriers to effective therapeutic delivery. These physical ba
Externí odkaz:
https://doaj.org/article/0659625801514f1886ff0385eb58649c
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 12633-12652 (2024)
Chenkai Wang,1,2 Zefan Shen,1,2 Yiyang Chen,1,2 Yifan Wang,2 Xuanyi Zhou,2 Xinyi Chen,1 Yuhang Li,2 Pu Zhang,2 Qi Zhang2 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Urology & Nep
Externí odkaz:
https://doaj.org/article/89ba1da66cb64104a395acb780905577
Autor:
Xuanrong Sun, Tenghan Zhang, Zhao Lou, Yujie Zhou, Yuteng Chu, Dongfang Zhou, Juhong Zhu, Yue Cai, Jie Shen
Publikováno v:
Green Chemical Engineering, Vol 6, Iss 1, Pp 116-125 (2025)
Drug resistance is a major obstacle in tumor therapy. One effective approach to overcoming this issue is by improving the penetration of drugs into the lesions. Here, we report size shrinkable dendrimer-lipid hybrid nanoassemblies (PATU-lipid-PEG/DOX
Externí odkaz:
https://doaj.org/article/b30603639bbb4640805cbd0971cd9c4e
Publikováno v:
Materials Today Bio, Vol 27, Iss , Pp 101119- (2024)
Cancer represents a significant threat to human health, with the use of traditional chemotherapy drugs being limited by their harsh side effects. Tumor-targeted nanocarriers have emerged as a promising solution to this problem, as they can deliver dr
Externí odkaz:
https://doaj.org/article/394d37248bee49aab4900f7888ecf34f
Autor:
Zheng Li, Yabo Zhu, Zhijie Zhang, Huimin Wang, Chong Wang, Chen Xu, Shiyou Li, Shuya Zhang, Xiangliang Yang, Zifu Li
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Aberrant tumor mechanical microenvironment (TMME), featured with overactivated cancer‐associated fibroblasts (CAFs) and excessive extracellular matrix (ECM), severely restricts penetration and accumulation of cancer nanomedicines, while mi
Externí odkaz:
https://doaj.org/article/3048920993cc43b39284eda2ea6e6aa5
Publikováno v:
Bioactive Materials, Vol 32, Iss , Pp 445-472 (2024)
Effective tumor treatment depends on optimizing drug penetration and accumulation in tumor tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key solution that addresses the rapid clearance of free drugs, but achieving deep drug
Externí odkaz:
https://doaj.org/article/55d6cdbfede742318b14043a16e60824
Autor:
Yixia Liang, Rong Lei, Jiabao Tan, Junyue Fang, Lin Yu, Shiyu Tan, Yan Nie, Qiongchao Jiang, Xiaoyun Xiao, Phei Er Saw
Publikováno v:
BIO Integration, Vol 4, Iss 4, Pp 170-179 (2023)
Antibody-drug conjugates (ADCs) have the following advantages: target specificity; wide therapeutic index; and prolonged circulation half-life. A key limitation of ADCs, however, is the large size (~150 kDa), which markedly slows diffusion through th
Externí odkaz:
https://doaj.org/article/cef41e8a3484474eaa4adac03c8ed53b
Publikováno v:
Advanced Science, Vol 11, Iss 3, Pp n/a-n/a (2024)
Abstract Hydrogels are prevailing drug delivery depots to improve antitumor efficacy and reduce systemic toxicity. However, the application of conventional free drug‐loaded hydrogel is hindered by poor drug penetration in solid tumors. Here, an inj
Externí odkaz:
https://doaj.org/article/2935d7ae3b3f4a0cb7821a635f043d67
Akademický článek
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Autor:
Mohammad Souri, Mohammad Kiani Shahvandi, Mohsen Chiani, Farshad Moradi Kashkooli, Ali Farhangi, Mohammad Reza Mehrabi, Arman Rahmim, Van M. Savage, M. Soltani
Publikováno v:
Drug Delivery, Vol 30, Iss 1 (2023)
AbstractNano-based drug delivery systems hold significant promise for cancer therapies. Presently, the poor accumulation of drug-carrying nanoparticles in tumors has limited their success. In this study, based on a combination of the paradigms of int
Externí odkaz:
https://doaj.org/article/b31e51f72dd94c9e87f94bfa66243f2e