Zobrazeno 1 - 10
of 393
pro vyhledávání: '"Tumor organoids"'
Autor:
Guolong Zeng, Yifan Yu, Meiting Wang, Jiaxing Liu, Guangpeng He, Sixuan Yu, Huining Yan, Liang Yang, Hangyu Li, Xueqiang Peng
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract The complexity of tumors and the challenges associated with treatment often stem from the limitations of existing models in accurately replicating authentic tumors. Recently, organoid technology has emerged as an innovative platform for tumo
Externí odkaz:
https://doaj.org/article/49b3e81a56da44db99e39b8cc217b1cd
Autor:
Lilian Roth, Linda Huynh-Russo, Laura Heeb, Sima Ulugöl, Rafael Freire Dos Santos, Eva Breuer, Udo Ungethüm, Martina Haberecker, Chantal Pauli, Viktor Koelzer, Kuno Lehmann, Anurag Gupta
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Multimodal therapy for peritoneal metastasis (PM) including cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provides long-term survival in highly selected colorectal cancer patients. Mechanisms behind HIPEC
Externí odkaz:
https://doaj.org/article/fad11af395664b6181c3d0cec33526fd
Challenges in validation of combination treatment strategies for CRC using patient-derived organoids
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-19 (2024)
Abstract Patient-derived organoids (PDOs) established from tissues from various tumor types gave the foundation of ex vivo models to screen and/or validate the activity of many cancer drug candidates. Due to their phenotypic and genotypic similarity
Externí odkaz:
https://doaj.org/article/010b61716bf24686873cba423601682b
Autor:
Lucie Thorel, Jordane Divoux, Justine Lequesne, Guillaume Babin, Pierre-Marie Morice, Romane Florent, Guillaume Desmartin, Lucie Lecouflet, Chloé Marde Alagama, Alexandra Leconte, Bénédicte Clarisse, Mélanie Briand, Roman Rouzier, Léopold Gaichies, Sandrine Martin-Françoise, Jean-François Le Brun, Christophe Denoyelle, Nicolas Vigneron, Corinne Jeanne, Cécile Blanc-Fournier, Raphaël Leman, Dominique Vaur, Martin Figeac, Matthieu Meryet-Figuiere, Florence Joly, Louis-Bastien Weiswald, Laurent Poulain, Enora Dolivet
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Ovarian cancer is the first cause of death from gynecological malignancies mainly due to development of chemoresistance. Despite the emergence of PARP inhibitors, which have revolutionized the therapeutic management of some of the
Externí odkaz:
https://doaj.org/article/088b590c02d14c37987eaddfddc2217f
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
A key challenge in cancer research is the meticulous development of models that faithfully emulates the intricacies of the patient scenario, with emphasis on preserving intra-tumoral heterogeneity and the dynamic milieu of the tumor microenvironment
Externí odkaz:
https://doaj.org/article/b43a30da78064a66942a4786b857fcc8
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The 3D culture of intestinal organoids entails embedding isolated intestinal crypts and bone marrow mesenchymal stem cells within a growth factor-enriched matrix gel. This process leads to the formation of hollow microspheres with structures resembli
Externí odkaz:
https://doaj.org/article/18cd88607a0b4f20999175816be9be1c
Autor:
Lucie Thorel, Pierre-Marie Morice, Hippolyte Paysant, Romane Florent, Guillaume Babin, Cécilia Thomine, Marion Perréard, Edwige Abeilard, Florence Giffard, Emilie Brotin, Christophe Denoyelle, Céline Villenet, Shéhérazade Sebda, Mélanie Briand, Florence Joly, Enora Dolivet, Didier Goux, Cécile Blanc-Fournier, Corinne Jeanne, Marie Villedieu, Matthieu Meryet-Figuiere, Martin Figeac, Laurent Poulain, Louis-Bastien Weiswald
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background In the era of personalized medicine, the establishment of preclinical models of cancer that faithfully recapitulate original tumors is essential to potentially guide clinical decisions. Methods We established 7 models [4 cell line
Externí odkaz:
https://doaj.org/article/fcc6d93e6e1648e1ac7194108ee99a59
Autor:
Jordane Divoux, Romane Florent, Margaux Jacobs, Justine Lequesne, Jean-Michel Grellard, Chankannira San, Sara Grossi, Katia Kerdja, Bénédicte Clarisse, Gwenaelle Boudier, François Cherifi, Mélanie Briand, Enora Dolivet, Alisson Johnson, Brice Dubois, Valentin Harter, Joëlle Lacroix, Charlotte Raboutet, Brigitte Marie, Nathalie Rousseau, Cécile Blanc-Fournier, Dominique Vaur, Martin Figeac, Laurent Poulain, Louis-Bastien Weiswald, George Emile
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Background Triple negative breast cancers (TNBC) account for approximately 15% of all breast cancers and are associated with a shorter median survival mainly due to locally advanced tumor and high risk of metastasis. The current neoadjuvant
Externí odkaz:
https://doaj.org/article/ca31ade11a73463e975df48ff00e460c
Autor:
Changchun Zhou, Yuanbo Wu, Zeyu Wang, Yanli Liu, Jiaqi Yu, Weiping Wang, Sunrui Chen, Weihua Wu, Jidong Wang, Guowei Qian, Aina He
Publikováno v:
Cancer Medicine, Vol 12, Iss 13, Pp 14375-14386 (2023)
Abstract Establishing a valid in vitro model to represent tumor heterogeneity and biology is critical but challenging. Tumor organoids are self‐assembled three‐dimensional cell clusters which are of great significance for recapitulating the histo
Externí odkaz:
https://doaj.org/article/c61c53b3ebd142a797733b3078dbc4b1
Autor:
Marwah Al-Aloosi, Amanda M. Prechtl, Payel Chatterjee, Brady Bernard, Christopher J. Kemp, Rachele Rosati, Robert L. Diaz, Lauren R. Appleyard, Shalini Pereira, Alex Rajewski, Amber McDonald, Eva J. Gordon, Carla Grandori
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Patients presenting with stage 4 ovarian carcinoma, including low-grade serous disease, have a poor prognosis. Although platinum-based therapies can offer some response, these therapies are associated with many side effects, and treatment resistance
Externí odkaz:
https://doaj.org/article/fcc76ebb292445b4b3f929be800bb6b7