Zobrazeno 1 - 10
of 2 197
pro vyhledávání: '"Tumor metabolism"'
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-33 (2024)
Abstract The tumor microenvironment demonstrates great immunophenotypic heterogeneity, which has been leveraged in traditional immune-hot/cold tumor categorization based on the abundance of intra-tumoral immune cells. By incorporating the spatial imm
Externí odkaz:
https://doaj.org/article/065f947302344946abdb8593e8cd1358
Autor:
Vicent Ribas
Publikováno v:
Exploration of Digestive Diseases, Vol 3, Iss 3, Pp 203-225 (2024)
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and its death rate is rising faster than that of any other cancer, while we still lack effective treatments. The increasing incidence of liver cancer in western countries is close
Externí odkaz:
https://doaj.org/article/f0659679c2c449b9bac3735b9a9c67d3
Autor:
Mohammad Sadiq Jeeyavudeen, Navin Mathiyalagan, Cornelius Fernandez James, Joseph M. Pappachan
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 2, Pp 349-373 (2024)
Pheochromocytomas and paragangliomas (PPGLs) have emerged as one of the most common endocrine tumors. It epitomizes fascinating crossroads of genetic, metabolic, and endocrine oncology, providing a canvas to explore the molecular intricacies of tumor
Externí odkaz:
https://doaj.org/article/07582557096c450bbfbb5f40fb4fc44c
Autor:
Shichao Yang, Caden Hu, Xiaomei Chen, Yi Tang, Juanjuan Li, Hanqing Yang, Yi Yang, Binwu Ying, Xue Xiao, Shang‑Ze Li, Li Gu, Yahui Zhu
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer cells constantly encounter the limits of insufficient oxygen and nutrient supplies. To satisfy
Externí odkaz:
https://doaj.org/article/0d1187fe97aa4c898e8fbb879b6881f6
Insights into metabolic heterogeneity of colorectal cancer gained from fluorescence lifetime imaging
Autor:
Anastasia D Komarova, Snezhana D Sinyushkina, Ilia D Shchechkin, Irina N Druzhkova, Sofia A Smirnova, Vitaliy M Terekhov, Artem M Mozherov, Nadezhda I Ignatova, Elena E Nikonova, Evgeny A Shirshin, Liubov E Shimolina, Sergey V Gamayunov, Vladislav I Shcheslavskiy, Marina V Shirmanova
Publikováno v:
eLife, Vol 13 (2024)
Heterogeneity of tumor metabolism is an important, but still poorly understood aspect of tumor biology. Present work is focused on the visualization and quantification of cellular metabolic heterogeneity of colorectal cancer using fluorescence lifeti
Externí odkaz:
https://doaj.org/article/5e57f664a6284bd389556bc991227b0a
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundArginine deprivation therapy (ADT) hinders glioma cells’ access to nutrients by reducing peripheral blood arginine, showing great efficacy in various studies, which suggests it as a potentially promising treatment for glioma. The aim of t
Externí odkaz:
https://doaj.org/article/aa96d2e804644b3c881409c8029b75f8
Autor:
Yulang Jiang, Mingyu Sun
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The non-natriuretic-dependent glutamate/cystine inverse transporter-system Xc- is composed of two protein subunits, SLC7A11 and SLC3A2, with SLC7A11 serving as the primary functional component responsible for cystine uptake and glutathione biosynthes
Externí odkaz:
https://doaj.org/article/b46e462694464bbd879bc3eed6f8eeba
Autor:
Melissa Schwab, Ali Bashiri Dezfouli, Mohammad Khosravi, Bayan Alkotub, Lisa Bauer, Mohammad Javed Tahmasebi Birgani, Gabriele Multhoff
Publikováno v:
Radiation Oncology, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Background An enhanced aerobic glycolysis (“Warburg effect”) associated with an increase in lactic acid in the tumor microenvironment contributes to tumor aggressiveness and resistance to radiation and chemotherapy. We investigated the r
Externí odkaz:
https://doaj.org/article/c683673f154c45f5ac78ef2a38c8ea32
Publikováno v:
Biomaterials and Biosystems, Vol 14, Iss , Pp 100093- (2024)
Recently, it has been recognized that physical abnormalities (e.g. elevated solid stress, elevated interstitial fluid pressure, increased stiffness) are associated with tumor progression and development. Additionally, these mechanical forces originat
Externí odkaz:
https://doaj.org/article/86b2fcf438c445768b98bc6786088965
Autor:
Seema Parte, Ramesh Pothuraju, Ranjith Kumavath, Rakesh Bhatia, Rama Krishna Nimmakayala, Shailendra Gautam
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/d7c37d85beda479484726ca0f3741838