Výsledky vyhledávání - "Tumor Necrosis Factor-alpha / pharmacology"

TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity

Autor: Mário A. Barbosa, Teresa Summavielle, Susana G. Santos, Jaime Freitas, Joana Bravo, Maria Inês Almeida, Joao Paulo Bras

Publikováno v: Cell Death and Disease, Vol 11, Iss 6, Pp 1-15 (2020)
Cell Death & Disease
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Growing evidences suggest that sustained neuroinflammation, caused by microglia overactivation, is implicated in the development and aggravation of several neurological and psychiatric disorders. In some pathological conditions, microglia produce inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401f63fb9a756b8fd8925ca8ee30868b
https://doi.org/10.1038/s41419-020-2626-6

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TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways

Autor: Izzettin Hatip-Al-Khatib, Funda F. Bölükbaşı Hatip, Junichi Matsumoto, Fuyuko Takata, Takashi Machida, Yasufumi Kataoka, Shinya Dohgu, Atsushi Yamauchi

Publikováno v: Brain Research. 1692:34-44

Interleukin (IL)-6 is an important mediator of neurovascular dysfunction, neurodegeneration and/or neuroinflammation. We previously reported that brain pericytes released higher levels of IL-6 than did glial cells (astrocytes and microglia) in respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706aba2f546c7b20734ef8cf336638f0
https://doi.org/10.1016/j.brainres.2018.04.023

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Silencing Mitogen-activated Protein 4 Kinase 4 (MAP4K4) Protects Beta Cells from Tumor Necrosis Factor-α-induced Decrease of IRS-2 and Inhibition of Glucose-stimulated Insulin Secretion

Autor: Philippe A. Halban, Pascale Ribaux, Karim Bouzakri

Publikováno v: Journal of Biological Chemistry, Vol. 284, No 41 (2009) pp. 27892-27898

Obesity and type 2 diabetes present partially overlapping phenotypes with systemic inflammation as a common feature, raising the hypothesis that elevated cytokine levels may contribute to peripheral insulin resistance as well as the decreased beta ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7060905830c636efb13276711f5e496b
https://doi.org/10.1074/jbc.m109.048058

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The Tumor Suppressor CYLD Interacts with TRIP and Regulates Negatively Nuclear Factor κB Activation by Tumor Necrosis Factor

Autor: Jia Wei Liu, Rune Toftgård, Marcel Huber, Alexandre Regamey, Priit Kogerman, Daniel Hohl, Thierry Roger

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 198, no. 12, pp. 1959-64

Cylindromas are benign adnexal skin tumors caused by germline mutations in the CYLD gene. In most cases the second wild-type allele is lost in tumor tissue, suggesting that CYLD functions as tumor suppressor. CYLD is a protein of 956 amino acids harb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97c1cadaf3d773cd1bb4938049fd1f5
http://europepmc.org/articles/PMC2194148

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Both TNF receptors are required for direct TNF‐mediated cytotoxicity in microvascular endothelial cells

Autor: Rudolf Lucas, Gabriel Núñez, Georges E. Grau, Michael S. Pepper, Wim A. Buurman, Christine Giroud, Yves Donati, Lucie Fransen, Peter M. Suter, Marusa Hribar, Irene Garcia, Stefano J. Mandriota

Publikováno v: European Journal of Immunology, 28(11), 3577-3586. Wiley
European Journal of Immunology, Vol. 28, No 11 (1998) pp. 3577-3586

Department of Anaesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, University of Geneva, Switzerland. lucas@cmu.unige.chThe conditions under which tumor necrosis factor-alpha (TNF) induces apoptosis in primary microva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913c38545717d7d2aef15e9610d62eb0
https://doi.org/10.1002/(sici)1521-4141(199811)28:11<3577::aid-immu3577>3.0.co

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Distribution, Differentiation, and Survival of Intravenously Administered Neural Stem Cells in a Rat Model of Amyotrophic Lateral Sclerosis

Autor: Roland Pochet, Dinko Mitrečić, Charles Nicaise, Srećko Gajović

Publikováno v: Cell Transplantation, Vol 19 (2010)
Cell transplantation, 19 (5

The transplantation of neural stem cells (NSCs) is a challenging therapeutic strategy for the treatment of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). To provide insight into the potential of the intravenous delivery of NS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d68bcc14f75f5fca99a017421ddb58
https://doaj.org/article/24ada53c3c4b4628a64bf2abdf56e3f1

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Heterogeneous regulation of constitutive thrombomodulin or inducible tissue-factor activities on the surface of human saphenous-vein endothelial cells in culture following stimulation by interleukin-1, tumour necrosis factor, thrombin or phorbol ester

Autor: Alain Beretz, G Archipoff, J P Cazenave, J M Freyssinet, Christine Brisson, C Klein-Soyer

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 1991, 273, pp.679-684

Thrombomodulin and tissue-factor activities were measured on the surface of confluent human saphenous-vein endothelial cells (HSVEC) cultivated in 96-multiwell plates. Thrombomodulin activity was measured in the presence of purified human thrombin (2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55755a3814a1174cef91862524ff156d
https://doi.org/10.1042/bj2730679

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Increased levels of c-fos and c-myc mRNA in ATP-stimulated endothelial cells

Autor: S. Reuse, O. Boutherin-Falson, Jean-Marie Boeynaems, Jacques Emile Dumont

Publikováno v: Biochemical and biophysical research communications, 172 (1

In bovine aortic endothelial cells, ATP induced a transient and sequential accumulation of c-fos and c-myc mRNA, which was detected after 1 hour and 3 hours, respectively. The effect of ATP on c-fos mRNA was stronger than that of TNF and bFGF. Both A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd08be9f31f43e36dc34dc0a6a1b1f25
https://doi.org/10.1016/s0006-291x(05)80210-4

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Tumor necrosis factor-alpha modifies adhesion properties of rat islet B cells

Autor: Vincenzo Cirulli, Dominique G. Rouiller, Philippe A. Halban

Publikováno v: Journal of Clinical Investigation, Vol. 91, No 5 (1993) pp. 1868-1876

The characteristic three-dimensional cell type organization of islets of Langerhans is perturbed in animal models of diabetes, suggesting that it may be important for islet function. Rat islet cells in culture are able to form aggregates with an arch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e46f5d30f6712b0448aacdc72f21662
https://archive-ouverte.unige.ch/unige:8691

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