Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses

Autor: Katherine Kedzierska, Dale I. Godfrey, Liyen Loh, James McCluskey, Carolien E. van de Sandt, Nicholas A Gherardin, E. Kaitlynn Allen, Paul G. Thomas, Sidonia B G Eckle, Martha Lappas, Thomas Loudovaris, Ludivine Grzelak, Jane Crowe, Kylie M. Quinn, Jeremy Chase Crawford, Hui-Fern Koay, Sneha Sant, Katie L. Flanagan, Nicola L. Bird, Marcela de Lima Moreira, Jamie Rossjohn

Publikováno v: Journal of immunology (Baltimore, Md., 204(5), 1119-1133. American Association of Immunologists
The Journal of Immunology

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to undergo marked numerical changes with age in humans, our understanding of how MAIT cells are altered during different phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c89e19a9231fbf54a016acadd9d1b6
https://doi.org/10.4049/jimmunol.1900774

Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy

Autor: Elisabeth A. Cats, W-Ludo van der Pol, Abraham C. J. Stork, Nicolette C. Notermans, Jan H. Veldink, Ruth D E Fritsch-Stork, Ben A.W. de Jong, Lotte Vlam, Ger T. Rijkers, Leonard H. van den Berg

Publikováno v: Muscle & Nerve, 59(6), 694-698. John Wiley & Sons Inc.
Muscle & Nerve, 59(6), 694. John Wiley and Sons Inc.

Introduction Polyneuropathy with immunoglobulin M monoclonal gammopathy (IgM-PNP) is associated with the presence of IgM antibodies against nerve constituents such as myelin associated glycoprotein (MAG) and gangliosides. Methods To test whether B-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6d006ccacc99a46ca4739a62651fbb
https://doi.org/10.1002/mus.26462

TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis

Autor: Alexander A. Navarini, Curdin Conrad, Alessio Mylonas, Anne-Karine Lapointe, Jeremy Di Domizio, Olivier Demaria, Michel Gilliet, Cyrine Belkhodja, Lars E. French, Maxime Vernez

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature communications, vol. 9, no. 1, pp. 25

Although anti-tumor necrosis factor (TNF) agents are highly effective in the treatment of psoriasis, 2–5% of treated patients develop psoriasis-like skin lesions called paradoxical psoriasis. The pathogenesis of this side effect and its distinction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbc7decb248c10970a313c075620f0f
https://doaj.org/article/180fc992d72e4fcbbf1d606055e86015

Tumor necrosis factormediated survival of CD169+ cells promotes immune activation during vesicular stomatitis virus infection

Autor: Nico van Rooijen, Andreas Kloetgen, Tak W. Mak, Prashant V. Shinde, Mathias Heikenwalder, Namir Shaabani, Stefanie Scheu, Jürgen Ruland, Sukumar Namineni, Yuan Zhuang, Aleksandra A. Pandyra, Dirk Brenner, Mirko Trilling, Nicolás Bellora, Mareike Doerrenberg, Arndt Borkhardt, Klaus Pfeffer, Percy A. Knolle, Philipp A. Lang, Haifeng C. Xu, Nadine Honke, Vitaly I. Pozdeev, Sathish Kumar Maney, Paul R. Crocker, Masato Tanaka, Sujitha Duggimpudi, Dieter Häussinger, Jessica I. Hoell, Karl S. Lang

Publikováno v: Shinde, P V, Xu, H C, Maney, S K, Kloetgen, A, Namineni, S, Zhuang, Y, Honke, N, Shaabani, N, Bellora, N, Doerrenberg, M, Trilling, M, Pozdeev, V I, van Rooijen, N, Scheu, S, Pfeffer, K, Crocker, P R, Tanaka, M, Duggimpudi, S, Knolle, P, Heikenwalder, M, Ruland, J R, Mak, T W, Brenner, D, Pandyra, A A, Hoell, J I, Borkhardt, A, Häussinger, D, Lang, K S & Lang, P A 2018, ' Tumor necrosis factormediated survival of CD169+ cells promotes immune activation during vesicular stomatitis virus infection ', Journal of Virology, vol. 92, no. 3, e01637-17 . https://doi.org/10.1128/JVI.01637-17
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Shinde, P V, Xu, H C, Maney, S K, Kloetgen, A, Namineni, S, Zhuang, Y, Honke, N, Shaabani, N, Bellora, N, Doerrenberg, M, Trilling, M, Pozdeev, V I, van Rooijen, N, Scheu, S, Pfeffer, K, Crocker, P R, Tanaka, M, Duggimpudi, S, Knolle, P, Heikenwalder, M, Ruland, J, Mak, T W, Brenner, D, Pandyra, A A, Hoell, J I, Borkhardt, A, Häussinger, D, Lang, K S & Lang, P A 2018, ' Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection ', Journal of Virology, vol. 92, no. 3, e01637-17, pp. e01637-17 . https://doi.org/10.1128/JVI.01637-17
Journal of virology
J. Virol. 92, DOI: 10.1128/JVI.01637-17 (2017)
Journal of Virology, 92(3):e01637-17. American Society for Microbiology
Journal of Virology

Innate immune activation is essential to mount an effective antiviral response and to prime adaptive immunity. Although a crucial role of CD169+ cells during vesicular stomatitis virus (VSV) infections is increasingly recognized, factors regulating C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad07de59d567d0c28c95469b650ca30
https://research.vumc.nl/en/publications/96c9f1d3-e363-4e3d-928c-33fea37bf29a

Association of IBD specific treatment and prevalence of pain in the Swiss IBD cohort study

Autor: Lorenz Bon, Pascal Frei, Thomas Greuter, Benjamin Misselwitz, Nicolas Fournier, Philipp Schreiner, Sylvie Scharl, Valerie Pittet, Gerhard Rogler, Jonas Zeitz, Michael Scharl, Stephan R. Vavricka, Luc Biedermann

Publikováno v: PloS one, vol. 14, no. 4, pp. e0215738
PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0215738 (2019)

BackgroundExtraintestinal manifestations (EIM) contribute significantly to the burden of disease in inflammatory bowel disease (IBD). Pain is a leading symptom in IBD and could be seen as an EIM itself. Treatment of IBD associated pain is challenging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2720e4e5cfc1be129d309dbe6082e244
https://doi.org/10.1371/journal.pone.0215738