Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

Autor: Daniel Peckham, Paul Whitaker, Anil Mehta, Sinisa Savic, Michael F. McDermott, T. Scambler, J. Holbrook, Christine Etherington, Ian Clifton, Heledd H. Jarosz-Griffiths, Samuel Lara-Reyna, Giulia Spoletini, C. Wong, Fabio Martinon

Publikováno v: eLife
eLife, Vol 9 (2020)
eLife, vol. 9, pp. e54556

Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56c3b19820b0ec649de1acb486b5ee6
https://eprints.whiterose.ac.uk/158253/7/elife-54556-v2.pdf

The bidirectional relationship between anxiety disorders and circulating levels of inflammatory markers: Results from a large longitudinal population-based study

Autor: Peter Vollenweider, Aurélie M. Lasserre, Caroline L. Vandeleur, Ciro Marangoni, En-Young N. Wagner, Gérard Waeber, Mehdi Gholam-Rezaee, Roland von Känel, Kathleen R. Merikangas, Enrique Castelao, Martin Preisig, Marie-Pierre F. Strippoli, Pedro Marques-Vidal, Jennifer Glaus

Publikováno v: Depression and anxiety, vol. 35, no. 4, pp. 360-371

BACKGROUND Although there has been abundant research on chronic low-grade inflammation as a potential mechanism underlying the link between mood disorders and cardiovascular risk, less is known about the role of inflammatory factors and anxiety disor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1561c7714ffa10a0de828f88583b8208
https://doi.org/10.5167/uzh-168035

Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study

Autor: R von Känel, M-P F Strippoli, Jennifer Glaus, Gérard Waeber, Aurélie M. Lasserre, Martin Preisig, Enrique Castelao, Pedro Marques-Vidal, Caroline L. Vandeleur, Kathleen R. Merikangas, En-Young N. Wagner, Ciro Marangoni, Mehdi Gholam-Rezaee, Peter Vollenweider

Publikováno v: Glaus, J; von Känel, R; Lasserre, A M; Strippoli, M-P F; Vandeleur, C L; Castelao, E; Gholam-Rezaee, M; Marangoni, C; Wagner, En-Young; Marques-Vidal, P; Waeber, G; Vollenweider, P; Preisig, M; Merikangas, K R (2018). Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study. Psychological medicine, 48(6), pp. 961-973. Cambridge University Press 10.1017/S0033291717002744
Psychological medicine, vol. 48, no. 6, pp. 961-973

BackgroundThere has been increasing evidence that chronic low-grade inflammation is associated with mood disorders. However, the findings have been inconsistent because of heterogeneity across studies and methodological limitations. Our aim is to pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aef6f33c06648d91cb6925748c013ec
https://pubmed.ncbi.nlm.nih.gov/28929992

Blood flow restricted training leads to myocellular macrophage infiltration and upregulation of heat shock proteins, but no apparent muscle damage

Autor: Nielsen, Jakob L, Aagaard, Per, Prokhorova, Tatyana A, Nygaard, Tobias, Bech, Rune Dueholm, Suetta, Charlotte, Frandsen, Ulrik

Publikováno v: Nielsen, J L, Aagaard, P, Prokhorova, T A, Nygaard, T, Bech, R D, Suetta, C & Frandsen, U 2017, ' Blood flow restricted training leads to myocellular macrophage infiltration and upregulation of heat shock proteins, but no apparent muscle damage ', Journal of Physiology, vol. 595, no. 14, pp. 4857–4873 . https://doi.org/10.1113/JP273907

Key points: Muscular contractions performed using a combination of low external loads and partial restriction of limb blood flow appear to induce substantial gains in muscle strength and muscle mass. This exercise regime may initially induce muscular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3062::228c3d21bdce371e494e1db186bc27f4
https://portal.findresearcher.sdu.dk/da/publications/fdb1b828-9dd9-4183-8f5c-a139a4f19944

Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice

Autor: Kate Lykke Lambertsen, Lujitha Suntharalingam, Minna Christiansen Lund, Åsa Fex Svenningsen, Bettina Hjelm Clausen, Roberta Brambilla, Louise Helskov Jørgensen, Ditte Gry Ellman, Simon Bertram Flæng, Matilda Degn, Hans Gram Novrup

Publikováno v: Mediators of Inflammation, Vol 2016 (2016)
Ellman, D G, Degn, M, Lund, M C, Clausen, B H, Novrup, H G, Flæng, S B, Jørgensen, L H, Suntharalingam, L, Fex Svenningsen, Å, Brambilla, R & Lambertsen, K L 2016, ' Genetic ablation of soluble TNF does not affect lesion size and functional recovery after moderate spinal cord injury in mice ', Mediators of Inflammation, vol. 2016, 2684098 . https://doi.org/10.1155/2016/2684098
Mediators of Inflammation

Traumatic spinal cord injury (SCI) is followed by an instant increase in expression of the microglial-derived proinflammatory cytokine tumor necrosis factor (TNF) within the lesioned cord. TNF exists both as membrane-anchored TNF (mTNF) and as cleave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4477ec1f760047f6a66b846e774a0f83
https://doaj.org/article/1cc8ee5996ce486f869f8aa2caec05f7