Effect of immunosuppressive drugs on cytokine production in canine whole blood stimulated with lipopolysaccharide or a combination of ionomycin and phorbol 12‐myristate 13‐acetate

Autor: Lakshmi Narayanan, Simon M. Firestone, Todd M. Archer, Caroline S Mansfield, Julien R.S. Dandrieux

Publikováno v: Dandrieux, J R S, Narayanan, L, Firestone, S, Archer, T M & Mansfield, C S 2019, ' Effect of immunosuppressive drugs on cytokine production in canine whole blood stimulated with lipopolysaccharide or a combination of ionomycin and phorbol 12-myristate 13-acetate ', Veterinary Medicine and Science, vol. 5, no. 2, pp. 199-205 . https://doi.org/10.1002/vms3.143
Veterinary Medicine and Science

A pharmacodynamic assay has been previously developed to monitor ciclosporin treatment in dogs by assessing inhibition of cytokine transcription after whole blood stimulation with 12‐myristate 13‐1 acetate and ionomycin (PMA/I). In this study, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05bee1d1ba6bdd4b8933ab4e8f82b9e
https://doi.org/10.1002/vms3.143

The effects of ozone therapy on caspase pathways, TNF-α, and HIF-1α in diabetic nephropathy

Autor: Güçlü A, Erken HA, Erken G, Dodurga Y, Yay A, Özçoban Ö, Şimşek H, Akçılar A, Koçak FE

BACKGROUND: Accelerated apoptosis plays a vital role in the development of diabetic vascular complications. Ozone may attenuate diabetic nephropathy by means of decreased apoptosis-related genes. The aim of our study was to investigate the effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3566::c18ae1697ec949943ce81492337b9f56

Differential regulation of cytokine production by PI3Kδ in human monocytes upon acute and chronic inflammatory conditions

Autor: Karim J. Brandt, Danielle Burger, Lyssia Gruaz, Jean-Michel Dayer, Nicolas Molnarfi

Publikováno v: Molecular Immunology, Vol. 45, No 12 (2008) pp. 3419-27

Deregulated production of cytokines, including IL-1beta, IL-6 and TNF plays an important role in chronic inflammation. Relevant to this condition, direct cellular contact with stimulated T cells is a potent inducer of cytokine production in human mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d76f8e2b51dd75bcc191d453e23a36e
https://doi.org/10.1016/j.molimm.2008.04.001

Anti-inflammatory Therapy With Simvastatin Improves Neuroinflammation and CNS Function in a Mouse Model of Metachromatic Leukodystrophy

Autor: Ulrich Matzner, Stijn Stroobants, Volkmar Gieselmann, Axel Stein, Rudi D'Hooge

Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a functional deficiency of the lysosomal enzyme arylsulfatase A. The prevailing late-infantile variant of MLD is characterized by widespread and progressive demyelination of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5141d5645782bb537d069cc8828185
https://hdl.handle.net/20.500.14017/a9d6f039-7801-40c8-a76b-2aabda0440e4

Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis

Autor: Beatrice, Duthey, Anita, Hübner, Sandra, Diehl, Sandra, Boehncke, Jeannette, Pfeffer, Wolf-Henning, Boehncke

Publikováno v: Experimental Dermatology, Vol. 19, No 7 (2010) pp. 661-666

The gamma amino butyric acid B (GABA(B)) receptor is a G protein-coupled receptor (GPCR) involved in synaptic transmission. Recent data indicate it to be also expressed on immune cells, along with chemokine receptors, which are also GPCRs. As GPCRs c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9c000e065b21a64e3e7cb81892ac56c0
https://archive-ouverte.unige.ch/unige:29851