Zobrazeno 1 - 10
of 1 674
pro vyhledávání: '"Tumor Models"'
Autor:
Hang Ke, Tao Yang, Faming Zhang, Cen Chen, Jingjing Wang, Jinping Liu, Xiaoyu An, Lingxin Xiong, Xianfei He, Lei Zhang, Qi-Xiang Li
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Certain immune-checkpoint inhibitors have a narrow therapeutic window (TW) as cancer therapeutics, and engineered dual-/multi-targeting agents could potentially widen the TW to bring true clinical benefits. We report a new rationally-designe
Externí odkaz:
https://doaj.org/article/ca9ac7b4a1eb404fab5c23f987819202
Autor:
Minghua Li, Yanhong Wang, Xiaoyang Lin, Haiqiang Yang, Xiaolin Zhang, Yun Bai, Xiankun Li, Lulu Zhang, Feng Cheng, Chuanhai Cao, Qingyu Zhou
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 3, Pp 600-626 (2024)
Aim: The main objective of this study was to investigate the antitumor effect of a mouse anti-human glypican-1 (GPC1) monoclonal antibody (mAb) on non-small cell lung carcinoma (NSCLC) and associated molecular mechanisms. Methods: The anti-proliferat
Externí odkaz:
https://doaj.org/article/83d4b1062b894c658d53bdaea8155123
Publikováno v:
BMC Urology, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Renal cell carcinoma, a leading cause of death in urological malignancies, arises from the nephron. Its characteristics include diversity in disease biology, varied clinical behaviors, different prognoses, and diverse responses to systemic t
Externí odkaz:
https://doaj.org/article/a50406c092674ed5acc211dd44fcf139
Autor:
Xiangran Cui, Jianhang Jiao, Lili Yang, Yang Wang, Weibo Jiang, Tong Yu, Mufeng Li, Han Zhang, Bo Chao, Zhonghan Wang, Minfei Wu
Publikováno v:
Materials Today Bio, Vol 28, Iss , Pp 101198- (2024)
Bioprinting is a groundbreaking technology that enables precise distribution of cell-containing bioinks to construct organoid models that accurately reflect the characteristics of tumors in vivo. By incorporating different types of tumor cells into t
Externí odkaz:
https://doaj.org/article/6bd564050ccf4ba7b27d168470ef73fb
Autor:
Alican Kuşoğlu, Deniz Örnek, Aslı Dansık, Ceren Uzun, Sena Nur Özkan, Sevgi Sarıca, Kardelen Yangın, Şevval Özdinç, Duygu Turan Sorhun, Nuriye Solcan, Efe Can Doğanalp, Øystein Arlov, Katherine Cunningham, Ismail C. Karaoğlu, Seda Kizilel, Ihsan Solaroğlu, Pınar Bulutay, Pınar Fırat, Suat Erus, Serhan Tanju, Şükrü Dilege, Gordana Vunjak‐Novakovic, Nurcan Tuncbag, Ece Öztürk
Publikováno v:
Advanced Science, Vol 11, Iss 36, Pp n/a-n/a (2024)
Abstract Tumor extracellular matrices (ECM) exhibit aberrant changes in composition and mechanics compared to normal tissues. Proteoglycans (PG) are vital regulators of cellular signaling in the ECM with the ability to modulate receptor tyrosine kina
Externí odkaz:
https://doaj.org/article/a63380413b3f4842a13ba93e08720412
Autor:
Anmi Jose, Pallavi Kulkarni, Jaya Thilakan, Murali Munisamy, Anvita Gupta Malhotra, Jitendra Singh, Ashok Kumar, Vivek M. Rangnekar, Neha Arya, Mahadev Rao
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Despite advancements in treatment protocols, cancer is one of the leading cause of deaths worldwide. Therefore, there is a need to identify newer and personalized therapeutic targets along with screening technologies to combat cancer. With t
Externí odkaz:
https://doaj.org/article/0e6245e997e244a0a3c9088ed927cc6b
Autor:
Alexander L. Rakhmilevich, Noah W. Tsarovsky, Mildred Felder, Jen Zaborek, Sritha Moram, Amy K. Erbe, Alexander A. Pieper, Dan V. Spiegelman, Emily M. Cheng, Cole M. Witt, Willem W. Overwijk, Zachary S. Morris, Paul M. Sondel
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe majority of experimental approaches for cancer immunotherapy are tested against relatively small tumors in tumor-bearing mice, because in most cases advanced cancers are resistant to the treatments. In this study, we asked if even late-
Externí odkaz:
https://doaj.org/article/29d00bafc93a4a5eba1dd4bd66f05425
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Organoids are in vitro 3D models that maintain their own tissue structure and function. They largely overcome the limitations of traditional tumor models and have become a powerful research tool in the field of oncology in recent years. Gynecological
Externí odkaz:
https://doaj.org/article/0bdc262ea75a4de5b0542a1d37dbf7b0
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-22 (2024)
Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from
Externí odkaz:
https://doaj.org/article/239a82f3f72a45e2ac331d69e2f3370d
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/1ef4f15529a3471ebeb259266b0810ad