Zobrazeno 1 - 10
of 539
pro vyhledávání: '"Tumor Immune Escape"'
Autor:
Xiaoxin Sun, Haotian Wu, Ling Tang, Abdullah Al-Danakh, Yuli Jian, Li Gong, Congchen Li, Xiao Yu, Guang Zeng, Qiwei Chen, Deyong Yang, Shujing Wang
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Bladder cancer (BC) ranks as the sixth cancer in males and the ninth most common cancer worldwide. Conventional treatment modalities, including surgery, radiation, chemotherapy, and immunotherapy, have limited efficacy in certain advanced in
Externí odkaz:
https://doaj.org/article/8e80721f6d8f4519b6b13d3ce4046fcb
Autor:
Andrea Nicolini, Paola Ferrari
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Metabolic reprogramming is a k`ey hallmark of tumors, developed in response to hypoxia and nutrient deficiency during tumor progression. In both cancer and immune cells, there is a metabolic shift from oxidative phosphorylation (OXPHOS) to aerobic gl
Externí odkaz:
https://doaj.org/article/9d09c1262a5d4bb4a47729bdfb8b31e5
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMP
Externí odkaz:
https://doaj.org/article/3e6e7efc7fde4f358e4731934a2e130c
Autor:
Shichao Zhang, Yang Liu, Yichi Sun, Qin Liu, Yan Gu, Ya Huang, Zhu Zeng, Fuzhou Tang, Yan Ouyang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract Dysregulation of R-loop homeostasis is closely related to various human diseases, including cancer. However, the causality of aberrant R-loops in tumor progression remains unclear. In this study, using single-cell RNA-sequencing datasets fro
Externí odkaz:
https://doaj.org/article/8a7e1fd62b564632ae3cbbe4f6d30738
Publikováno v:
Journal of Advanced Research, Vol 54, Iss , Pp 147-179 (2023)
Background: Tripartite motif (TRIM) family proteins have more than 80 members and are widely found in various eukaryotic cells. Most TRIM family proteins participate in the ubiquitin-proteasome degradation system as E3-ubiquitin ligases; therefore, t
Externí odkaz:
https://doaj.org/article/10f523c205b945ae8e1e7cd2f44fd011
Autor:
Jinhuan Xian, Leilei Gao, Zhenyang Ren, Yanjun Jiang, Junjun Pan, Zheng Ying, Zhenyuan Guo, Qingsong Du, Xu Zhao, He Jin, Hua Yi, Jieying Guan, Shan Hu
Publikováno v:
Cells, Vol 13, Iss 18, p 1537 (2024)
Impaired tumor cell antigen presentation contributes significantly to immune evasion. This study identifies Berbamine hydrochloride (Ber), a compound derived from traditional Chinese medicine, as an effective inhibitor of autophagy that enhances anti
Externí odkaz:
https://doaj.org/article/740adb1626ee454ba3ebe0834bf8d6b6
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 7, Pp 1143-1147 (2023)
The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energ
Externí odkaz:
https://doaj.org/article/f397958d76a743dc83cd5688d22313c7
Nano‐Regulator Inhibits Tumor Immune Escape via the 'Two‐Way Regulation' Epigenetic Therapy Strategy
Autor:
Shuang Liang, Meichen Liu, Weiwei Mu, Tong Gao, Shuying Gao, Shunli Fu, Shijun Yuan, Jinhu Liu, Yongjun Liu, Dandan Jiang, Na Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract Tumor immune escape caused by low levels of tumor immunogenicity and immune checkpoint‐dependent suppression limits the immunotherapeutic effect. Herein, a “two‐way regulation” epigenetic therapeutic strategy is proposed using a nove
Externí odkaz:
https://doaj.org/article/9e2c282fed074761a5f80200edac5908
Autor:
Mingming Zheng, Wenxin Zhang, Xi Chen, Hongjie Guo, Honghai Wu, Yanjun Xu, Qiaojun He, Ling Ding, Bo Yang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1488-1497 (2023)
Lipids have been found to modulate tumor biology, including proliferation, survival, and metastasis. With the new understanding of tumor immune escape that has developed in recent years, the influence of lipids on the cancer–immunity cycle has also
Externí odkaz:
https://doaj.org/article/1bba42c2c7e5463ba5240e82cf3c3196
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Immune cells can protect against tumor progression by killing cancer cells, while aberrant expression of the immune checkpoint protein PD‐L1 (programmed death ligand 1) in cancer cells facilitates tumor immune escape and inhibits anti‐tu
Externí odkaz:
https://doaj.org/article/191955d2ee91439488c5460a23140c8e