AlphaFold2 structures template ligand discovery.

Autor: Lyu J; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA.; The Evnin Family Laboratory of Computational Molecular Discovery, The Rockefeller University, New York, NY 10065, USA (present address)., Kapolka N; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA., Gumpper R; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA., Alon A; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Pharmacology Department, Yale School of Medicine, New Haven, CT 06510, USA (present address)., Wang L; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Jain MK; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA., Barros-Álvarez X; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Sakamoto K; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA.; National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), School of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA., Kim Y; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA., DiBerto J; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA., Kim K; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA.; Department of Pharmacy, College of Pharmacy, Yonsei University, Incheon 21983, Korea (present address)., Tummino TA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Huang S; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Irwin JJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Tarkhanova OO; Chemspace LLC, Kyiv, 02094, Ukraine., Moroz Y; Chemspace LLC, Kyiv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine.; Enamine Ltd., Kyiv, 02094, Ukraine., Skiniotis G; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, US., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Shoichet BK; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Roth BL; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA.; National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), School of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA.; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 13. Date of Electronic Publication: 2024 Mar 13.

Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets.

Autor: Haas KM; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., McGregor MJ; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Bouhaddou M; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Polacco BJ; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Kim EY; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Nguyen TT; J. David Gladstone Institutes, San Francisco, CA, 94158, USA., Newton BW; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA., Urbanowski M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Kim H; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Williams MAP; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Rezelj VV; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Paris, France., Hardy A; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Paris, France., Fossati A; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Stevenson EJ; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Sukerman E; Division of Infectious Diseases, Oregon Health & Science University, Portland, OR, 97239, USA., Kim T; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Penugonda S; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Moreno E; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, Madrid, Spain.; Centro de Investigación en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Braberg H; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Zhou Y; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Metreveli G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Harjai B; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Tummino TA; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA.; Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California San Francisco, San Francisco, CA, 94158, USA., Melnyk JE; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Soucheray M; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Batra J; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Pache L; Infectious and Inflammatory Disease Center, Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Martin-Sancho L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Department of Infectious Disease, Imperial College London, London, SW7 2BX, UK., Carlson-Stevermer J; Synthego Corporation, Redwood City, CA, 94063, USA.; Serotiny Inc., South San Francisco, CA, 94080, USA., Jureka AS; Molecular Virology and Vaccine Team, Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization & Respiratory Diseases, Centers for Disease Control & Prevention, Atlanta, GA, 30333, USA.; General Dynamics Information Technology, Federal Civilian Division, Atlanta, GA, 30329, USA., Basler CF; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Shokat KM; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA., Shoichet BK; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA., Shriver LP; Department of Chemistry, Washington University in St. Louis, St. Louis, MO, 63105, USA.; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO, 63105, USA., Johnson JR; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Shaw ML; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Medical Biosciences, University of the Western Cape, Bellville, 7535, Western Cape, South Africa., Chanda SK; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Carter TC; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, 54449, USA., Kottyan LC; Center of Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA., Chisholm RL; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Pacheco JA; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Smith ME; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Schrodi SJ; Laboratory of Genetics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, 53706, USA., Albrecht RA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Vignuzzi M; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Paris, France., Zuliani-Alvarez L; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Swaney DL; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Eckhardt M; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Wolinsky SM; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., White KM; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Hultquist JF; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA. judd.hultquist@northwestern.edu.; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. judd.hultquist@northwestern.edu.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, IL, 60611, USA. judd.hultquist@northwestern.edu., Kaake RM; J. David Gladstone Institutes, San Francisco, CA, 94158, USA. robyn.kaake@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA. robyn.kaake@ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA. robyn.kaake@ucsf.edu.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA. robyn.kaake@ucsf.edu., García-Sastre A; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA. adolfo.garcia-sastre@mssm.edu.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu., Krogan NJ; J. David Gladstone Institutes, San Francisco, CA, 94158, USA. nevan.krogan@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA. nevan.krogan@ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA. nevan.krogan@ucsf.edu.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA. nevan.krogan@ucsf.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 27; Vol. 14 (1), pp. 6030. Date of Electronic Publication: 2023 Sep 27.

Structures of the σ 2 receptor enable docking for bioactive ligand discovery.

Autor: Alon A; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Lyu J; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Braz JM; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA., Tummino TA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.; Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, San Francisco, CA, USA., Craik V; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA., O'Meara MJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Webb CM; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.; Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, San Francisco, CA, USA., Radchenko DS; Enamine, Kyiv, Ukraine.; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine., Moroz YS; Chemspace, Kyiv, Ukraine., Huang XP; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Liu Y; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Roth BL; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Irwin JJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Basbaum AI; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA. Allan.Basbaum@ucsf.edu., Shoichet BK; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA. shoichet@cgl.ucsf.edu., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Andrew_Kruse@hms.harvard.edu.

Publikováno v: Nature [Nature] 2021 Dec; Vol. 600 (7890), pp. 759-764. Date of Electronic Publication: 2021 Dec 08.

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.

Autor: Tummino TA; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA.; Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, UCSF, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), UCSF, San Francisco, CA, USA.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA., Rezelj VV; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75724 Paris, Cedex 15, France., Fischer B; Novartis Institutes for BioMedical Research, Preclinical Safety, Basel, Switzerland., Fischer A; Novartis Institutes for BioMedical Research, Preclinical Safety, Basel, Switzerland., O'Meara MJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Monel B; Institut Pasteur, Virus and Immunity Unit, CNRS UMR 3569, 75724 Paris, Cedex 15, France., Vallet T; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75724 Paris, Cedex 15, France., White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhang Z; Quantitative Biosciences Institute (QBI), UCSF, San Francisco, CA, USA.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA, USA.; Howard Hughes Medical Institute, UCSF, San Francisco, CA, USA., Alon A; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Schadt H; Novartis Institutes for BioMedical Research, Preclinical Safety, Basel, Switzerland., O'Donnell HR; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA., Lyu J; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), UCSF, San Francisco, CA, USA.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA., Rosales R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., McGovern BL; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rathnasinghe R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jangra S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schotsaert M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Galarneau JR; Novartis Institutes for BioMedical Research, Preclinical Safety, Cambridge, MA, USA., Krogan NJ; Quantitative Biosciences Institute (QBI), UCSF, San Francisco, CA, USA.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Urban L; Novartis Institutes for BioMedical Research, Preclinical Safety, Cambridge, MA, USA., Shokat KM; Quantitative Biosciences Institute (QBI), UCSF, San Francisco, CA, USA.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA, USA.; Howard Hughes Medical Institute, UCSF, San Francisco, CA, USA., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schwartz O; Institut Pasteur, Virus and Immunity Unit, CNRS UMR 3569, 75724 Paris, Cedex 15, France., Moretti F; Novartis Institutes for BioMedical Research, Preclinical Safety, Basel, Switzerland. bshoichet@gmail.com francois.pognan@novartis.com marco.vignuzzi@pasteur.fr francesca.moretti@novartis.com., Vignuzzi M; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75724 Paris, Cedex 15, France. bshoichet@gmail.com francois.pognan@novartis.com marco.vignuzzi@pasteur.fr francesca.moretti@novartis.com., Pognan F; Novartis Institutes for BioMedical Research, Preclinical Safety, Basel, Switzerland. bshoichet@gmail.com francois.pognan@novartis.com marco.vignuzzi@pasteur.fr francesca.moretti@novartis.com., Shoichet BK; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA. bshoichet@gmail.com francois.pognan@novartis.com marco.vignuzzi@pasteur.fr francesca.moretti@novartis.com.; Quantitative Biosciences Institute (QBI), UCSF, San Francisco, CA, USA.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2021 Jul 30; Vol. 373 (6554), pp. 541-547. Date of Electronic Publication: 2021 Jun 22.

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

Autor: Gordon DE; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Hiatt J; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA.; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA., Bouhaddou M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Rezelj VV; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France., Ulferts S; Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany., Braberg H; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Jureka AS; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA., Obernier K; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Guo JZ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Batra J; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Kaake RM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Weckstein AR; Aetion, Inc., New York, NY 10001, USA., Owens TW; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Gupta M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Pourmal S; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Titus EW; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Cakir M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. 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David Gladstone Institutes, San Francisco, CA 94158, USA., Lind AL; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Klesh RJ; HealthVerity, Philadelphia, PA 19103, USA., Hemphill KR; Department of Neurology, University of California, San Francisco, CA 94143, USA., Carlson-Stevermer J; Synthego Corporation, Redwood City, CA 94063, USA., Oki J; Synthego Corporation, Redwood City, CA 94063, USA., Holden K; Synthego Corporation, Redwood City, CA 94063, USA., Maures T; Synthego Corporation, Redwood City, CA 94063, USA., Pollard KS; J. 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David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Medicine, University of California, San Francisco, CA 94143, USA., Palmarini M; MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK., Shokat KM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rassen JA; Aetion, Inc., New York, NY 10001, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Grosse R; Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; Centre for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, 79104 Freiburg, Germany., Rosenberg OS; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.; Department of Medicine, University of California, San Francisco, CA 94143, USA., Verba KA; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Basler CF; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Vignuzzi M; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Peden AA; Department of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Beltrao P; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Krogan NJ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Dec 04; Vol. 370 (6521). Date of Electronic Publication: 2020 Oct 15.