Tumburu L, Ghosh-Choudhary S, Seifuddin FT, et al. Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease. Blood. 2021;137(22):3116-3126

Publikováno v: Blood

The pathophysiology of sickle cell disease (SCD) is driven by chronic inflammation fueled by damage associated molecular patterns (DAMPs). We show that elevated cell-free DNA (cfDNA) in patients with SCD is not just a prognostic biomarker, it also co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::beeeae4e76f5b69a76b12241cf3f2b22
https://europepmc.org/articles/PMC9479025/

A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease.

Autor: Xu JZ; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Conrey A; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Frey I; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Gwaabe E; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Menapace LA; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Tumburu L; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Lundt M; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Lequang T; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Li Q; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Glass K; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Dunkelberger EB; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Iyer V; Agios Pharmaceuticals, Inc., Cambridge, MA., Mangus H; Agios Pharmaceuticals, Inc., Cambridge, MA., Kung C; Agios Pharmaceuticals, Inc., Cambridge, MA., Dang L; Agios Pharmaceuticals, Inc., Cambridge, MA., Kosinski PA; Agios Pharmaceuticals, Inc., Cambridge, MA., Hawkins P; Agios Pharmaceuticals, Inc., Cambridge, MA., Jeffries N; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD., Eaton WA; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD., Lay Thein S; Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

Publikováno v: Blood [Blood] 2022 Nov 10; Vol. 140 (19), pp. 2053-2062.

Targeting ZNF410 as a potential β-hemoglobinopathy therapy.

Autor: Tumburu L; National Heart, Lung and Blood Institute/NIH, Sickle Cell Branch, Bethesda, MD, USA., Thein SL; National Heart, Lung and Blood Institute/NIH, Sickle Cell Branch, Bethesda, MD, USA. sl.thein@nih.gov.

Publikováno v: Nature genetics [Nat Genet] 2021 May; Vol. 53 (5), pp. 589-590.

METTL16 participates in haemoglobin H disease through m⁶A modification.

Autor: Liao, Yuping¹ (AUTHOR), Zhang, Feng^1,2 (AUTHOR), Yang, Fang³ (AUTHOR), Huang, Shijin³ (AUTHOR), Su, Sha³ (AUTHOR), Tan, Xuemei¹ (AUTHOR), Zhong, Linlin³ (AUTHOR), Deng, Lingjie¹ (AUTHOR), Pang, Lihong^1,4,5,6,7 (AUTHOR) panglihong@sr.gxmu.edu.cn

Publikováno v: PLoS ONE. 8/1/2024, Vol. 19 Issue 8, p1-24. 24p.

Nucleic Acids-Based Biomarkers for Alzheimer's Disease Diagnosis and Novel Molecules to Treat the Disease.

Autor: Bivona, Giulia¹ (AUTHOR) giulia.bivona@unipa.it, Sammataro, Selene² (AUTHOR) selenesammataro@gmail.com, Ghersi, Giulio³ (AUTHOR) giulio.ghersi@unipa.it

Publikováno v: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7893. 13p.