Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tuman, Robert W."'
Autor:
Eichenbaum, Gary *, Hsu, C.-P., Subrahmanyam, Vangala, Chen, Jing, Scicinski, Jan, Galemmo, Robert A., Jr., Tuman, Robert W., Johnson, Dana L.
Publikováno v:
In Journal of Pharmaceutical Sciences July 2012 101(7):2545-2556
Autor:
Danielle Lawrence, Yanmin Chen, Mark J. Wall, Carl L. Manthey, Christopher J. Molloy, Edward J. Yurkow, Kenneth J. Wilson, Sanath K. Meegalla, Dana L. Johnson, Carol F. Franks, Bruce E. Tomczuk, Lee Zeng, Shelley K. Ballentine, Baumann Christian Andrew, Zhao Zhou, Judith Baker, Robert R. Donatelli, Lisa Boczon, Carl Crysler, Carl R. Illig, Heidi Ott, Jinsheng Chen, Tuman Robert W, Margery A. Chaikin
Publikováno v:
Molecular Cancer Therapeutics. 8:3151-3161
There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1dcd64b489777dd1393ee065709ba7
https://doi.org/10.1158/1535-7163.mct-09-0255
https://doi.org/10.1158/1535-7163.mct-09-0255
Publikováno v:
Molecular Cancer Therapeutics. 4:1198-1204
With the advent of agents directed against specific molecular targets in drug discovery, it has become imperative to show a compound's cellular impact on the intended biomolecule in vivo. The objective of the present study was to determine if we coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad7f8842c8a045d465cf1fc9d8f9411
https://doi.org/10.1158/1535-7163.mct-05-0004
https://doi.org/10.1158/1535-7163.mct-05-0004
Autor:
Jan Scicinski, Jing Chen, Robert A. Galemmo, Dana L. Johnson, Gary Eichenbaum, Cheng Pang Hsu, Vangala V. Subrahmanyam, Tuman Robert W
Publikováno v:
Journal of pharmaceutical sciences. 101(7)
Extensive first-pass metabolism can significantly limit a drug's oral exposure levels. In this work, we introduce an innovative approach for increasing the oral bioavailability of a drug that undergoes extensive reversible glucuronidation and enteroh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa3a8a639b429607da3d9112d5ccf36
https://pubmed.ncbi.nlm.nih.gov/22473491
https://pubmed.ncbi.nlm.nih.gov/22473491
Autor:
Shyamali Ghosh, Bart L. DeCorte, Tuman Robert W, S.E. Bursell, William A. Kinney, Alan C. Clermont, Li Liu, Rosemary J. Santulli, Robert A. Galemmo, Norman Huebert, Lynn C. Shaw, Shaker A. Mousa, Dana L. Johnson, Bruce E. Maryanoff, Bruce P. Damiano, Zhao Zhou, Maria B. Grant
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 324(3)
The alpha(V) integrins are key receptors involved in mediating cell migration and angiogenesis. In age-related macular degeneration (AMD) and diabetic retinopathy, angiogenesis plays a critical role in the loss of vision. These ocular vasculopathies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7d6910b2d1d109bf1156a0865cdc8b
https://pubmed.ncbi.nlm.nih.gov/18083913
https://pubmed.ncbi.nlm.nih.gov/18083913
Autor:
Peter J. Connolly, Michael Reuman, Dana L. Johnson, Martin J. Perry, Gilles Bignan, Anne Foley, Angel R. Fuentes-Pesquera, David Moffatt, O'connell James Philip, Tuman Robert W, Susan J. Hazel, Stuart Emanuel, Jennifer A. Seamon, Beth Hollister, Rodger A. Allen, Cheryl Napier, Rose Tominovich, Steven A. Middleton, Mark James Batchelor, Robert H. Gruninger, Linda K. Jolliffe, Michael R. D'Andrea
Publikováno v:
Molecular pharmacology. 66(3)
Inhibition of angiogenesis may have wide use in the treatment of cancer; however, this approach alone will not cause tumor regression but may only slow the growth of solid tumors. The clinical potential of antiangiogenic agents may be increased by co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ab2139adfdd2385b9c656ac0276095
https://pubmed.ncbi.nlm.nih.gov/15322256
https://pubmed.ncbi.nlm.nih.gov/15322256
Autor:
Ceusters Marc Andre, Marcel Gerebernus Maria Luyckx, Wouters Walter Boudewijn Leopo, Raymond Antoine Stokbroekx, Marcel Jozef Maria Van Der Aa, Mark Herb, Gerda Smets, Jean-Pierre Bongartz, Lieven Meerpoel, Charlie Bowden, Lisa Valletta, Rose Tominovich, Tuman Robert W, Marc Willems, Tine Jansen
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
General screening for inhibitors of microvessel growth in vitro in the rat aortic ring assay led to the discovery of a novel series of thiadiazole pyridazine compounds with potential anti-angiogenic activity. Chemical optimization produced orally act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a339ae563fd1d8549c036d23eb9cb3b0
https://pubmed.ncbi.nlm.nih.gov/11844678
https://pubmed.ncbi.nlm.nih.gov/11844678
Autor:
Tine Jansen, Gerda Smets, Lisa Valletta, Wouters Walter Boudewijn Leopo, Rose Tominovich, Charlie Bowden, Jean-Pierre Bongartz, Marcel Gerebernus Maria Luyckx, Ceusters Marc Andre, Raymond Antoine Stokbroekx, Marcel Jozef Maria Van Der Aa, Marc Willems, Tuman Robert W, Lieven Meerpoel, Mark Herb
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1133-1134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fdb984bfea5e78feff1cb3fcf59b7d8
https://doi.org/10.1016/s0960-894x(02)00116-6
https://doi.org/10.1016/s0960-894x(02)00116-6
Publikováno v:
Journal of medicinal chemistry. 36(11)
Nitrogen heterocyclic carboximidamides, such as linogliride, 1a, have been shown to possess significant hypoglycemic activity and have shown clinical efficacy as potential antidiabetic agents. We evaluated the biological significance of the heterocyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac11db64558b8e56a537ba7e73ecb91
https://pubmed.ncbi.nlm.nih.gov/8496927
https://pubmed.ncbi.nlm.nih.gov/8496927
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