Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tulp Martinus Th M"'
Publikováno v:
Journal of Medicinal Chemistry. 38:4303-4308
A series of unsubstituted and substituted succinimido, maleimido, and glutarimidoethyl derivatives of eltoprazine (3) was synthesized and tested for affinity for the 5-HT 1A receptor in rat brain homogenates. The unsubstituted compounds have a modera
Autor:
de Jonge A, Berend Olivier, Tipker J, van Hes R, Hamminga D, van Wijngaarden I, Tulp Martinus Th M, Standaar Pj, Mol F
Publikováno v:
Journal of Medicinal Chemistry. 36:3693-3699
On the basis of the structures of ondansetron and GR 65,630, its ring-opened C-linked methylimidazole analogue, novel 1,7-annelated indole derivatives were synthesized as potential 5-HT3 antagonists. Receptor binding studies show that all compounds d
Autor:
B. Olivier, Schipper Jacques, J. Mos, L. Bosch, G. van der Poel, A. van Hest, Tulp Martinus Th M, J.A.M. van der Heyden
Publikováno v:
Pharmacopsychiatry. 26:2-9
Serotonin (5-HT) reuptake inhibitors (SSRIs) such as fluvoxamine are interesting compounds. Initially launched as antidepressants, they have been found to be active in various psychiatric disorders besides depression, including obsessive-compulsive d
Autor:
J.A.M. van der Heyden, Jan Mos, B. Olivier, Schipper Jacques, Tulp Martinus Th M, G. van der Poel
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 6:S63-S71
Chlorimipramine, fluvoxamine and fluoxetine are clinically effective in obsessive-compulsive disorder (OCD) and inhibit serotonin (5-HT) reuptake. There are as yet no validated animal models for OCD. Therefore evidence for clinical efficacy in this i
Autor:
C. G. Kruse, P. J. Standaar, N. Veldman, W. Kuipers, I. Van Wijngaarden, Anthony L. Spek, Tulp Martinus Th M, Adriaan P. IJzerman
Publikováno v:
Journal of medicinal chemistry. 40(3)
We investigated the structural requirements for high 5-HT1A affinity of the agonist flesinoxan and its selectivity versus D2 receptors. For this purpose a series of arylpiperazine congeners of flesinoxan were synthesized and evaluated for their abili
Autor:
Adriaan P. IJzerman, van Wijngaarden I, W. Kuipers, Tulp Martinus Th M, ter Horst-van Amstel M, C. G. Kruse
Publikováno v:
Journal of medicinal chemistry. 38(11)
In order to explore the structural requirements for high 5-HT 1A affinity, a series of arylsubstituted N 1 -phenylpiperazines were synthesized and evaluated for their ability to displace [ 3 H]-8-OH-DPAT from its specific binding sites in rat frontal
Publikováno v:
European Journal of Pharmacology. 183:2148-2149
Publikováno v:
Behavioural Pharmacology. 3:38
Publikováno v:
ChemInform. 20