Zobrazeno 1 - 10
of 384
pro vyhledávání: '"Tullio Pozzan"'
Autor:
Annamaria Lia, Gabriele Sansevero, Angela Chiavegato, Miriana Sbrissa, Diana Pendin, Letizia Mariotti, Tullio Pozzan, Nicoletta Berardi, Giorgio Carmignoto, Cristina Fasolato, Micaela Zonta
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Altered Ca2+ signaling is involved in the pathogenesis of Alzheimer’s disease. Here, the authors show Ca2+ hypoactivity in astrocytes at plaque deposition onset related to reduced expression of the Ca2+ sensor STIM1 and impaired synaptic plasticity
Externí odkaz:
https://doaj.org/article/2692d4385d9d452f9a4c2132e63f0f7d
Autor:
Elisa Greotti, Ilaria Fortunati, Diana Pendin, Camilla Ferrante, Luisa Galla, Lorena Zentilin, Mauro Giacca, Nina Kaludercic, Moises Di Sante, Letizia Mariotti, Annamaria Lia, Marta Gómez-Gonzalo, Michele Sessolo, Giorgio Carmignoto, Renato Bozio, Tullio Pozzan
Publikováno v:
iScience, Vol 16, Iss , Pp 340-355 (2019)
Summary: Genetically Encoded Ca2+ Indicators (GECIs) are extensively used to study organelle Ca2+ homeostasis, although some available probes are still plagued by a number of problems, e.g., low fluorescence intensity, partial mistargeting, and pH se
Externí odkaz:
https://doaj.org/article/68a895b0109142569ddc88129249e310
Autor:
Elisa Greotti, Tullio Pozzan
Publikováno v:
Bio-Protocol, Vol 10, Iss 3 (2020)
Calcium (Ca2+) imaging aims at investigating the dynamic changes in live cells of its concentration ([Ca2+]) in different pathophysiological conditions. Ca2+ is an ubiquitous and versatile intracellular signal that modulates a large variety of cellul
Externí odkaz:
https://doaj.org/article/62c1d00cc85d4369adab79d9bb44d621
Autor:
Alessandro Leparulo, Marta Bisio, Nelly Redolfi, Tullio Pozzan, Stefano Vassanelli, Cristina Fasolato
Publikováno v:
Cells, Vol 11, Iss 2, p 238 (2022)
For Alzheimer’s disease (AD), aging is the main risk factor, but whether cognitive impairments due to aging resemble early AD deficits is not yet defined. When working with mouse models of AD, the situation is just as complicated, because only a fe
Externí odkaz:
https://doaj.org/article/7a496efd4ed64a2098cf7bb6e15fc89f
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9945 (2021)
Calcium (Ca2+) exerts a pivotal role in controlling both physiological and detrimental cellular processes. This versatility is due to the existence of a cell-specific molecular Ca2+ toolkit and its fine subcellular compartmentalization. Study of the
Externí odkaz:
https://doaj.org/article/d2dbc06568e84e70b5c9b4f7329e0379
Publikováno v:
Cells, Vol 10, Iss 8, p 2046 (2021)
In Alzheimer’s disease (AD), the molecular mechanisms involved in the neurodegeneration are still incompletely defined, though this aspect is crucial for a better understanding of the malady and for devising effective therapies. Mitochondrial dysfu
Externí odkaz:
https://doaj.org/article/82d4811629a0468aa74f31970f0431ff
Autor:
Alice Rossi, Luisa Galla, Chiara Gomiero, Lorena Zentilin, Mauro Giacca, Valentina Giorgio, Tito Calì, Tullio Pozzan, Elisa Greotti, Paola Pizzo
Publikováno v:
Cells, Vol 10, Iss 2, p 204 (2021)
Alzheimer′s disease (AD) is the most common age-related neurodegenerative disorder in which learning, memory and cognitive functions decline progressively. Familial forms of AD (FAD) are caused by mutations in amyloid precursor protein (APP), prese
Externí odkaz:
https://doaj.org/article/64c87adde9e44832bde17315e88c959e
Autor:
Riccardo Filadi, Elisa Greotti, Gabriele Turacchio, Alberto Luini, Tullio Pozzan, Paola Pizzo
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2226-2238 (2016)
Communication between organelles plays key roles in cell biology. In particular, physical and functional coupling of the endoplasmic reticulum (ER) and mitochondria is crucial for regulation of various physiological and pathophysiological processes.
Externí odkaz:
https://doaj.org/article/2949ced184f94370b7ddf6757664b549
Autor:
Paola Pizzo, Emy Basso, Riccardo Filadi, Elisa Greotti, Alessandro Leparulo, Diana Pendin, Nelly Redolfi, Michela Rossini, Nicola Vajente, Tullio Pozzan, Cristina Fasolato
Publikováno v:
Cells, Vol 9, Iss 10, p 2166 (2020)
Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer’s disease (FAD). It forms the catalytic core of the γ-secretase complex—a function shared with its homolog presenilin-1 (PS1)—the enzyme ultimate
Externí odkaz:
https://doaj.org/article/77b7dcffd7784e8b81cd1a266393c925
Autor:
Elena Scremin, Mario Agostini, Alessandro Leparulo, Tullio Pozzan, Elisa Greotti, Cristina Fasolato
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5288 (2020)
Senile plaques, the hallmarks of Alzheimer’s Disease (AD), are generated by the deposition of amyloid-beta (Aβ), the proteolytic product of amyloid precursor protein (APP), by β and γ-secretase. A large body of evidence points towards a role for
Externí odkaz:
https://doaj.org/article/2783470917f743429e39d353975dcaab