Výsledky vyhledávání - "Tullia V. Johnston"

Akademický článek

CNS4 causes subtype‐specific changes in agonist efficacy and reversal potential of permeant cations in NMDA receptors

Autor: Seth C. Boehringer, Tullia V. Johnston, Lina Cortez Kwapisz, Pamela J. VandeVord, Blaise M. Costa

Publikováno v: Pharmacology Research & Perspectives, Vol 11, Iss 3, Pp n/a-n/a (2023)

Abstract The NMDA subtype of glutamate receptor serves as an attractive drug target for the treatment of disorders evolving from hyper‐ or hypoglutamatergic conditions. Compounds that optimize the function of NMDA receptors are of great clinical si

Externí odkaz: https://doaj.org/article/bf9ddc7068374ce594afa09b45a6747c

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Akademický článek

A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons

Autor: Blaise M. Costa, Lina Cortés Kwapisz, Brittney Mehrkens, Douglas N. Bledsoe, Bryanna N. Vacca, Tullia V. Johnston, Rehan Razzaq, Dhanasekaran Manickam, Bradley G. Klein

Publikováno v: Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)

Abstract Precisely controlled synaptic glutamate concentration is essential for the normal function of the N‐methyl D‐aspartate (NMDA) receptors. Atypical fluctuations in synaptic glutamate homeostasis lead to aberrant NMDA receptor activity that

Externí odkaz: https://doaj.org/article/af4e8464cbf4484c997b749172315022

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Pharmacology Research & Perspectives

Autor: Rehan Razzaq, Bradley G. Klein, Blaise M. Costa, Tullia V. Johnston, Bryanna N. Vacca, Douglas N. Bledsoe, Dhanasekaran Manickam, Lina Cortés Kwapisz, Brittney Mehrkens

Publikováno v: Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)

Precisely controlled synaptic glutamate concentration is essential for the normal function of the N‐methyl D‐aspartate (NMDA) receptors. Atypical fluctuations in synaptic glutamate homeostasis lead to aberrant NMDA receptor activity that results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7040629e3e67dff531be67cd53f89f3
https://doi.org/10.1002/prp2.859

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