Výsledky vyhledávání - "Tullia C, Bruno"

Akademický článek

Challenges and opportunities in cancer immunotherapy: a Society for Immunotherapy of Cancer (SITC) strategic vision

Autor: James L Gulley, Deborah Collyar, Pedro J Romero, Christian M Capitini, Leisha A Emens, Avery D Posey, Patrick Hwu, Jennifer A Wargo, Ann W Silk, Ana Carrizosa Anderson, Tullia C Bruno

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)

Cancer immunotherapy has flourished over the last 10–15 years, transforming the practice of oncology and providing long-term clinical benefit to some patients. During this time, three distinct classes of immune checkpoint inhibitors, chimeric antig

Externí odkaz: https://doaj.org/article/ba0feaa1364741509df21dfe108b7d2c

Zobrazit plný text záznamu

Akademický článek

Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundProinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME). In the current study, we sought to investigate the prognostic value of TLS-associated che

Externí odkaz: https://doaj.org/article/ebb1daa835334b64a636560bfe79e186

Zobrazit plný text záznamu

Akademický článek

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Mutations of ESR1, the gene encoding the estrogen receptor alpha, are associated with acquired resistance to therapy in luminalbreast cancer. Here the authors show that ESR1 mutant tumors gain basal-like features with increased expression of basal cy

Externí odkaz: https://doaj.org/article/3ce70acd6e2e4c66a89d08122c1ec702

Zobrazit plný text záznamu

Akademický článek

Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

The tumor microenvironment (TME) has an important role in Head and Neck Squamous Cell Carcinoma (HNSCC) progression. Here, using single-cell RNA sequencing and multiplexed imaging, the authors report the cellular complexity of the TME in patients wit

Externí odkaz: https://doaj.org/article/2771653d57ef4d11b987a7dbc52724d2

Zobrazit plný text záznamu

Akademický článek

Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

Autor: Alyssa Vito, Omar Salem, Nader El-Sayes, Ian P. MacFawn, Ana L. Portillo, Katy Milne, Danielle Harrington, Ali A. Ashkar, Yonghong Wan, Samuel T. Workenhe, Brad H. Nelson, Tullia C. Bruno, Karen L. Mossman

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)

Vito et al. investigated the effects of combination therapy in a TNBC tumor model and reported increased tumor-infiltrating lymphocytes that contributed to an improved response to immune checkpoint blockade. By depletion of circulating B cells prior

Externí odkaz: https://doaj.org/article/05222c9ff4534f789861496bd23f86ca

Zobrazit plný text záznamu

Akademický článek

B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in

Externí odkaz: https://doaj.org/article/e83ecb50387b47eaba497a672e531424

Zobrazit plný text záznamu

Akademický článek

A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies

Autor: Zhe Sun, Li Chen, Hongyi Xin, Yale Jiang, Qianhui Huang, Anthony R. Cillo, Tracy Tabib, Jay K. Kolls, Tullia C. Bruno, Robert Lafyatis, Dario A. A. Vignali, Kong Chen, Ying Ding, Ming Hu, Wei Chen

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

With the development of large scale single cell RNA-seq technology, population-scale scRNA-seq studies are emerging. Here, the authors develop BAMM-SC, a tool for clustering droplet-based scRNA-seq data from multiple individuals simultaneously.

Externí odkaz: https://doaj.org/article/52d49e5908374e5ea58127ece365e62a

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání