Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tulin Tatar"'
Autor:
Debbie L Cunningham, Andrew J Creese, Giulio Auciello, Steve M M Sweet, Tulin Tatar, Joshua Z Rappoport, Melissa M Grant, John K Heath
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61513 (2013)
Eps8 is involved in both cell signalling and receptor trafficking. It is a known phosphorylation substrate for two proteins involved in the fibroblast growth factor receptor (FGFR) signalling pathway: the receptor itself and Src. Here we report a dif
Externí odkaz:
https://doaj.org/article/e655224b4683456292e217457d30eff3
Autor:
Aditya Sankar, Faizaan Mohammad, Arun Kumar Sundaramurthy, Hua Wang, Mads Lerdrup, Tulin Tatar, Kristian Helin
Publikováno v:
Nat Genet
A new study employs CRISPR/Cas9-based base editing for simultaneous mutagenesis of all copies of histone H3 genes in mammals, highlighting the functional importance of H3K27me3 for Polycomb-mediated gene silencing and the dispensability for H3K27ac i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b897405c6663ad9f80a2824ad46026b7
https://doi.org/10.1038/s41588-022-01091-2
https://doi.org/10.1038/s41588-022-01091-2
Autor:
Helene Damhofer, Tülin Tatar, Benjamin Southgate, Scott Scarneo, Karl Agger, Daria Shlyueva, Lene Uhrbom, Gillian M. Morrison, Philip F. Hughes, Timothy Haystead, Steven M. Pollard, Kristian Helin
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-17 (2024)
Abstract Poor survival and lack of treatment response in glioblastoma (GBM) is attributed to the persistence of glioma stem cells (GSCs). To identify novel therapeutic approaches, we performed CRISPR/Cas9 knockout screens and discovered TGFβ activat
Externí odkaz:
https://doaj.org/article/9c882069fd714df8a02c424b20d4f84c
Publikováno v:
Journal of Cell Science. 126:613-624
Summary Fibroblast growth factor receptors (FGFRs) mediate a wide spectrum of cellular responses that are crucial for development and wound healing. However, aberrant FGFR activity leads to cancer. Activated growth factor receptors undergo stimulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f18137dca831416d2f0c93893f8b136
https://doi.org/10.1242/jcs.116228
https://doi.org/10.1242/jcs.116228
Autor:
Iris Müller, Ann Sophie Moroni, Daria Shlyueva, Sudeep Sahadevan, Erwin M. Schoof, Aliaksandra Radzisheuskaya, Jonas W. Højfeldt, Tülin Tatar, Richard P. Koche, Chang Huang, Kristian Helin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of
Externí odkaz:
https://doaj.org/article/9597bd4ec7404890a76dbc8df6a59f5c
Autor:
Andrea Corsinotti, Frederick CK Wong, Tülin Tatar, Iwona Szczerbinska, Florian Halbritter, Douglas Colby, Sabine Gogolok, Raphaël Pantier, Kirsten Liggat, Elham S Mirfazeli, Elisa Hall-Ponsele, Nicholas P Mullin, Valerie Wilson, Ian Chambers
Publikováno v:
eLife, Vol 6 (2017)
Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (EpiSC)
Externí odkaz:
https://doaj.org/article/383310e3d27d44c8aad4b1b095ff1014