4-Thiazolidinone Derivatives as MMP Inhibitors in Tissue Damage: Synthesis, Biological Evaluation and Docking Studies

Autor: Matteo Incerti, Lucia Crascì, Paola Vicini, Esin Aki, Ismail Yalcin, Tugba Ertan-Bolelli, Venera Cardile, Adriana Carol Eleonora Graziano, Annamaria Panico

Publikováno v: Molecules, Vol 23, Iss 2, p 415 (2018)

Nine 2-(1,2-benzothiazol-3-yl)-N-(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)propanamides combining a benzisothiazole and 4-thiazolidinone in one framework were designed and synthesized. The aim of the study was to verify their effectiveness to affect the i

Externí odkaz: https://doaj.org/article/5856ce1354284cb7a6722e537e31437d

Towards a Better Understanding of Computational Models for Predicting DNA Methylation Effects at the Molecular Level

Autor: Kayhan Bolelli, Ethan Will Taylor, J. Phillip Bowen, Norman H. L. Chiu, Tugba Ertan-Bolelli, Nathanael K. Proctor

Publikováno v: Current Topics in Medicinal Chemistry. 20:901-909

Human DNA is a very sensitive macromolecule and slight changes in the structure of DNA can have disastrous effects on the organism. When nucleotides are modified, or changed, the resulting DNA sequence can lose its information, if it is part of a gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8b1df7ecc8cef65aff6423698b322b
https://doi.org/10.2174/1568026620666200226110019

Biological activity and ADME/Tox prediction of some 2-substituted benzoxazole derivatives

Autor: Fatma Zilifdar Foto, Egemen Foto, Tugba Ertan-Bolelli, Ilkay Yildiz

Publikováno v: Bioorganic Chemistry. 123:105756

In this study, we mainly focused on some in vitro biological activities of a series of (5 or 6)-amino-2- (substituted phenyl and benzyl) benzoxazole derivatives. For this purpose, we tested cytotoxic and genotoxic activities of them on cancer cell li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c88584374fac60e8019ee023e0b4ce
https://doi.org/10.1016/j.bioorg.2022.105756

Head-to-head bisbenzazole derivatives as antiproliferative agents: design, synthesis, in vitro activity, and SAR analysis

Autor: Nizami Duran, Mehmet Abdullah Alagöz, Oztekin Algul, Ronak Haj Ersan, Serdar Burmaoglu, Tugba Ertan-Bolelli

Publikováno v: Molecular diversity. 25(4)

In the present work, a series of bisbenzazole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of these compounds was investigated using MTT assay. Bisbenzazole derivatives showed significant antip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47c70d6f4a14ef9704871b7c3eb1caa
https://pubmed.ncbi.nlm.nih.gov/32556804

Pharmacophore-Based Virtual Screening of Novel GSTP1-1 Inhibitors

Autor: Kayhan Bolelli, Tugba Ertan-Bolelli

Publikováno v: Journal of the Turkish Chemical Society, Section A: Chemistry, Vol 5, Iss 3, Pp 1279-1286 (2018)
Volume: 5, Issue: 3 1279-1286
Journal of the Turkish Chemical Society Section A: Chemistry

Glutathione transferase enzymes play an important role in metabolism and detoxification of numerous xenobiotics, electrophilic drugs, environmental carcinogens, and products of oxidative stress in living organisms. Human GST P1-1 is the most prevalen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15b0c14fdd7c77e73ca58f03999c624
http://dergipark.gov.tr/jotcsa/issue/37193/466458